2020 Annual Meeting Poster: Heidi Lindroth

2020 Annual Meeting Poster: Heidi Lindroth

Presentation Title: Delirium Incidence, Duration and Severity in Critically Ill Patients with COVID-19

Author Name(s): Sikandar Khan2,4, Heidi Lindroth 2,3,4; Jessica Hammes1; Babar Khan2,4,5,6

Author Department and School Affiliation: 1Indiana University School of Medicine Indianapolis, IN; 2Division of Pulmonary, Critical Care, Sleep and Occupational Medicine, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN; 3Indiana University School of Nursing, Indianapolis, IN; 4IU Center of Aging Research, Regenstrief Institute, Indianapolis, IN; 5Indiana University Center of Health Innovation and Implementation Science, Indianapolis, IN; 6Sandra Eskenazi Center for Brain Care Innovation, Eskenazi Hospital, Indianapolis, IN

Abstract: COVID-19 is associated with severe respiratory failure and high mortality in critically ill patients.2,4,5 Neurologic manifestations of the disease, including delirium and coma, may also be associated with poor clinical outcomes. Delirium is associated with prolonged mechanical ventilation and mortality.3 This study sought to describe the rates, duration, and severity of delirium in patients admitted to the ICU with COVID-19.

A retrospective, observational study was conducted from March 1stto April 27th, 2020, at Indiana University Health Methodist and Eskenazi Health Hospitals. The primary outcomes were delirium rates and duration; the secondary outcome was delirium severity. Of 144 patients in the study, 73.6% experienced delirium and 76.4% experienced delirium or coma. Mechanical ventilation was associated increased risk of developing delirium (OR: 22.65, 95% CL: 5.24-97.82). Mortality was also more likely in patients experiencing delirium: 26.4%

Of the 144 patients included, 73.6% experienced delirium lasting on average 5 days: the median delirium score being severe. Mechanical ventilation was also associated with greater odds of developing delirium. Because Covid-19 is associated with high rates of delirium, leading to increased rates of functionality disability, more resources and attention are needed to prevent and manage delirium in patients.1


  1. Brummel NE, Jackson JC, Pandharipande PP, et al. Delirium in the ICU and subsequent long-term disability among survivors of mechanical ventilation. Critical Care Medicine. 2014;42(2):369-377.
  2. Grasselli G, Pesenti A, Cecconi M. Critical Care Utilization for the COVID-19 Outbreak in Lombardy, Italy: Early Experience and Forecast During an Emergency Response. JAMA. 2020.
  3. Hayhurst CJ, Pandharipande PP, Hughes CG. Intensive Care Unit Delirium: A Review of Diagnosis, Prevention, and Treatment. Anesthesiology. 2016;125(6):1229-1241.
  4. Li YC, Bai WZ, Hashikawa T. The neuroinvasive potential of SARS-CoV2 may play a role in the respiratory failure of COVID-19 patients. J Med Virol. 2020.
  5. Wu Y, Xu X, Chen Z, et al. Nervous system involvement after infection with COVID-19 and other coronaviruses. Brain, behavior, and immunity. 2020:S0889-1591(0820)30357-30353.
|2020-09-09T18:28:19-04:00September 2nd, 2020|Annual Meeting Posters|0 Comments

About the Author: James Dudley

James Dudley

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