Presentation Title: Radioluminescent nanoparticles for combination chemoradiotherapy of locally advanced head and neck cancers
Author Name(s): Kaustabh Sarkar1, You-Yeon Won2
Author Department and School Affiliation: 1Graduate Research Assistant, Purdue University; 2Professor of Chemical Engineering, Purdue University
Abstract: Head and neck squamous cell carcinomas are the 8th most common cancers detected annually in the United States. A concurrent chemotherapy and radiotherapy (“chemoradiation”) regimen is currently the standard of care for locally advanced head and neck tumors. However, chemoradiation causes several severe toxic side effects in a significant portion of the patient population. A formulation consisting of calcium tungstate nanoparticles encapsulated with polyethylene glycol-b-polylactic acid loaded with paclitaxel (PEG-PLA/CWO/PTX) has been developed to provide localized radiation triggered intratumoral chemoradiation. The drug release rate of PTX from the formulation can be controlled using radiation dose and frequency, a strategy that can be used to maintain a therapeutic concentration of drugs in the tumor for an extended period. The difference in stereochemistry of loaded PTX on the in vitro and in vivo efficacy of PEG-PLA/CWO/PTX formulation has been studied. The stereochemistry of PTX affects the in vitro release kinetics and causes significant differences in the in vivo efficacy of the formulation in mouse xenograft models. The differences in stereochemistry may not cause significant differences when used in free form but can significantly affect its performance when used within nanomedicine drug delivery carriers.