2020 Annual Meeting Poster: Tarunendu Mapder

2020 Annual Meeting Poster: Tarunendu Mapder

Presentation Title: Innate and Adaptive Immune Response to SARS-CoV-2 Infection Play Major Role in Disease Severity

Author Name(s): Tarunendu Mapder1, Sara K. Quinney1,2, Richard F. Bergstrom1, Robert E. Stratford1

Author Department and School Affiliation: 1Division of Clinical Pharmacology, Department of Medicine, Indiana University
School of Medicine, Indianapolis, IN 46202, USA; 2Department of Obstetrics and Gynecology, Indiana University School of
Medicine, Indianapolis, IN 46202, USA

Abstract: The rapid transmission of SARS-CoV-2 in a community is manifested by a wide range of symptoms of coronavirus disease 2019 including fever, pneumonia, acute respiratory distress syndrome and lymphopenia. SARS-CoV-2 infection exhibits fast virus-shedding and long incubation period. Hence, community transmission is faster than disease manifestation and detection of infection. We propose the emergent “cytokine storm” and wrongly-posed immune response as the major regulators in disease severity. We calibrated a population of models (POMs) with clinical data for 23 patients across days of symptom onset. The calibration of the POMs is performed by matching the multivariate distributions of the observed data and model outputs. Our model indicates that feedback regulation among the antigen presenting cells, helper T-cells and cytokines contribute to the cytokine pool and T-cell exhaustion. When the adaptive immune response is triggered, B-cells differentiate into plasma cells that produce the IgM and IgG, simultaneously. A decision switch between long- and short-living plasma cells and their conversion was able to model different scenarios of seroconversion. We were able to model viral and immune response following SARSCoV-2 infection. This model may inform development of intervention strategies through antivirals, monoclonal antibodies, cytotoxic T-cell gene therapy and inhibitors for cytokine receptors.

|2020-09-09T19:19:26-04:00September 2nd, 2020|Annual Meeting Posters|0 Comments

About the Author: James Dudley

James Dudley

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