Clinical Characteristics Within a cohort study of 1641 adult patients with SARS-CoV-2, an elevated red blood cell distribution width (RDW) at admission and increasing RDW during hospitalization were associated with statistically higher increased in mortality risk. Within this meta-analysisRead More
Clinical Characteristics: Within this surveillance cohort of 598 hospitalized pregnant women with COVID-19, 55% were asymptomatic at admission. Among these pregnant women, 2% had pregnancy losses during COVID-19-associated hospitalizations and were experienced by both symptomatic and asymptomatic women. Inflammation: WithinRead More
Clinical characteristics This cross-sectional study examined racial/ethnic variation in nasal gene expression of trans-membrane serine protease 2 (TMPRSS2). Within the 305 individuals with tissue samples (nasal epithelium collected during 2015-2018), TMPRSS2 expression was significantly higher in Black individuals compared withRead More
Clinical Characteristics In this case series of 91 children who tested positive for COVID-19 in Korea, 22% were asymptomatic. These children were tested for COVID-19 when they had a history of close contact with confirmed cases. Only 8.5% of symptomaticRead More
Clinical Characteristics This prospective observational cohort study describes the clinical characteristics of 651 children and adolescents from England, Wales, and Scotland, of which 52 met WHO criteria for MIS-C. In addition to the WHO diagnostic criteria, children with MIS-C wereRead More
Transmission A small study of 18 breastfeeding women with COVID-19 found that SARS-CoV-2 RNA was found in only one sample, and a viral culture from that sample was negative. This suggests that breast milk is an unlikely source of infectionRead More
Personal Protective Equipment A quality improvement study looking at comparative fitted filtration efficiencies for various mask styles found N95 makes had efficiencies of 98.%; surgical mask with ties was 71.5%; procedure mask with ear loops was 38.1%. Used and/or expiredRead More
Case reports: A case report of early-onset, severe COVID-19 infection in a neonate was published, suggestive of vertical transmission. Another case report describes an infant who present with incomplete Kawaski Disease as their primary symptoms of COVID-19 infection. Treatment: WithinRead More
Clinical Testing and Evaluations In a cohort of 145 patients with mild to moderate COVID-19 illness, replication of SARS-CoV-2 in older children led to similar levels of viral RNA as adults, but significantly greater amounts are detected in children youngerRead More
Vaccine Update: The mRNA-1273 vaccine (from Moderna and NIAID) induced anti-SARS-COV-2 immune responses (anti-Spike-2P glycoprotein antibody) in all participants and no trial-limiting safety concerns were identified. Epidemiology: During hospital-wide SARS-CoV-2 antibody (Ab) screening in healthcare workers (HCW) and staff inRead More