What is reciprocal innovation? Reciprocal innovation builds on the concept of ‘reverse innovation’, a process of bringing healthcare innovations and technologies designed and tested in under-resourced countries around the world back to developed countries such as the United States to address important health challenges. These ‘reverse innovations’ are attractive because they are often seen as more cost-effective; easy to replicate, scale, and sustain; require minimal infrastructure; and can be tailored to local needs. However, reverse innovation implies a unidirectional process that does not continue to engage global health stakeholders in refining and implementing these approaches. Reciprocal innovation evolves the concept of reverse innovation in order to create a bidirectional research agenda that provides mutual benefit to both sides and identifies high quality innovations from our global health partnerships for demonstration, replication, and dissemination through our statewide system.