Review: A cross‐sectional community‐based observational study of asymptomatic SARS‐CoV‐2 prevalence in the greater Indianapolis area

This cross-sectional study found that the prevalence of SARS-CoV-2 in the asymptomatic adult population of the Indianapolis metropolitan area was 3.1%

  • Study called asymptomatic novel CORonavirus iNfection (ACORN), led by Eli Lilly researchers between April 7, 2020 and May 16, 2020.
  • All adult study participants had to be free of the following 3 symptoms:  in the last 7‐days: fever (≥100°F), new onset or worsening cough, and new onset or worsening shortness of breath. Patients were followed up at 14 days to see if they had developed any symptoms.
  • SARS‐CoV‐2 infection was determined by RT‐PCR in nasopharyngeal swab samples.
  • 2953 participants were enrolled and underwent testing
  • Among tested participants, 91 (3.1%; 95%‐CI; 2.5%‐3.7%) were positive for SARS‐CoV‐2.
  • Baseline characteristics, medical history, and infection risk factors were comparable between SARS‐CoV‐2 positive and negative participants. Within the 14‐day follow‐up period for positive participants, 28.4% (n=23) now report one or more symptoms, the others remained asymptomatic
  • These results indicate screening questions had limited predictive utility for testing in an asymptomatic population and suggest broader testing strategies are needed.
|2020-06-19T11:10:03-04:00June 18th, 2020|COVID-19 Literature|Comments Off on Review: A cross‐sectional community‐based observational study of asymptomatic SARS‐CoV‐2 prevalence in the greater Indianapolis area

About the Author: Megan McHenry

Megan McHenry
Megan S. McHenry, MD, MS, FAAP is a pediatrician and an Assistant Professor of Pediatrics in the Ryan White Center for Pediatric Infectious Disease and Global Health at Indiana University School of Medicine. Dr. McHenry's research focuses on early childhood development in children living in resource-limited settings. This work is frequently aligned with community-engaged research and dissemination and implementation science frameworks. She primarily conducts research in collaboration with the Academic Model for Providing Access to Healthcare (AMPATH) Research Network in Kenya. Dr. McHenry currently has a career development award through the National Institutes of Health to develop a neurodevelopmental screening program for children born to HIV-infected mothers in Kenya. Dr. McHenry is also the Director of Pediatric Global Health Education and a co-Director of the Morris Green Physician-Scientist Development Program at Indiana University School of Medicine. In additional to global health lectures, she also educates residents and students on early childhood development, basic biostatistical techniques, research methodologies, and research ethics. She mentors multiple pediatric fellows, residents, and medical students interested in early childhood development within global contexts.

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