Review: Comparative replication and immune activation profiles of SARS-CoV-2 and SARS-CoV in human lungs: An ex vivo study with implications for the pathogenesis of COVID-19

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Review: Comparative replication and immune activation profiles of SARS-CoV-2 and SARS-CoV in human lungs: An ex vivo study with implications for the pathogenesis of COVID-19

Review: Comparative replication and immune activation profiles of SARS-CoV-2 and SARS-CoV in human lungs: An ex vivo study with implications for the pathogenesis of COVID-19

This study provides quantitative data on the comparative replication capacity and immune activation of SARS-CoV-2 versus SARS-CoV infection in human lung tissue, providing insight on why it is more infections, bur provokes less of a response in patients.

COVID-19 spreads easily, but we don’t completely understand the underlying mechanism confers its high transmissibility and asymptomatic infections. Researchers investigated the replication, cell tropism, and immune activation profile of SARS-CoV-2 infection in human lung tissues compared to SARS-CoV.

They found that SARS-CoV-2 both infected and replicated in human lung tissue more efficiently than SARS-CoV. In 48 hours, SARS-CoV-2 generated more than three times the infectious virus particles than SARS-CoV. However, despite its more efficient replication, SARS-CoV-2 did not significantly induce types I, II, or III interferons in the infected human lung tissue. Further, SARS-CoV upregulated the expression of 85% of representative pro-inflammatory cytokines/chemokines, while SARS-CoV-2 only upregulated 38% of them.

|2020-04-14T13:58:46-04:00April 10th, 2020|COVID-19 Literature|Comments Off on Review: Comparative replication and immune activation profiles of SARS-CoV-2 and SARS-CoV in human lungs: An ex vivo study with implications for the pathogenesis of COVID-19

About the Author: Aaron Carroll

Aaron Carroll

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