Review: Viral loads in throat and anal swabs in children infected with SARS-CoV-2

This retrospective study found inconsistent results of RT-PCR-testing using throat and anal swabs for monitoring SARS-CoV-2 infection.

  • RT-PCR assay on throat and anal swabs were simultaneously tested in 212 of 2138 pediatric patients with suspected SARS-CoV-2 infection in Wuhan Children’s Hospital. 78 of 212 patients were confirmed with SARS-CoV-2 infection according to the positive results obtained from either throat or anal swabs
  • Of the 78 patients, 17 were positive on anal swabs and 37 were positive on throat swabs, as well as 24 were double positive.
  • The diagnostic potential of these two types of specimens showed significant difference (positive rate: 78.2% on throat swabs vs. 52.6% on anal swabs, McNemar Test P = 0.0091) and exhibited a weak positive consistency with Kappa value was 0.311 (P < 0.0001).
  • Viral loads showed no difference and correlation between throat and anal swabs.
  • Further research is needed to determine if there is a fecal-oral route of transmission for SARs-CoV-2
|2020-05-21T08:43:25-04:00May 20th, 2020|COVID-19 Literature|Comments Off on Review: Viral loads in throat and anal swabs in children infected with SARS-CoV-2

About the Author: Megan McHenry

Megan McHenry
Megan S. McHenry, MD, MS, FAAP is a pediatrician and an Assistant Professor of Pediatrics in the Ryan White Center for Pediatric Infectious Disease and Global Health at Indiana University School of Medicine. Dr. McHenry's research focuses on early childhood development in children living in resource-limited settings. This work is frequently aligned with community-engaged research and dissemination and implementation science frameworks. She primarily conducts research in collaboration with the Academic Model for Providing Access to Healthcare (AMPATH) Research Network in Kenya. Dr. McHenry currently has a career development award through the National Institutes of Health to develop a neurodevelopmental screening program for children born to HIV-infected mothers in Kenya. Dr. McHenry is also the Director of Pediatric Global Health Education and a co-Director of the Morris Green Physician-Scientist Development Program at Indiana University School of Medicine. In additional to global health lectures, she also educates residents and students on early childhood development, basic biostatistical techniques, research methodologies, and research ethics. She mentors multiple pediatric fellows, residents, and medical students interested in early childhood development within global contexts.

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