In Vivo Therapeutics Core

/In Vivo Therapeutics Core/

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In Vivo Therapeutics Core

Director:   Karen E. Pollok, Ph D.
Manager:   Tony Sinn


The IUSCC In Vivo Therapeutics Core (IVT) provides investigators with cost-effective and comprehensive services to facilitate the development and testing of novel pharmacological & cellular therapies. The Core will act as a liaison between the Principal Investigator and any other outcome analyses from live-phase studies. The IVT Core maintains multiple on-site breeding colonies, including: NOD/scid, NOD/scid/IL2Rgnull, Boy/J, F1/BoyJxC57Bl/6 mice, C57BL/6-Tg(UBC-GFP)30Scha/J, and Mgmt -/-

Policies: Services Offered:
  • Complete blood count (20 parameters)
  • In Vivo Tumor Growth Kinetics – Established lines include: SKOV-3X (Ovarian), A549 & H460 (Lung), MCF-7 & TMD-231 (Breast), C32 (Melanoma), H929 (Multiple Myeloma), Raji (Non Hodgkin
  • Pharmacological Investigations: In vitro toxicity testing utilizing primary human hematopoietic cells and clonogenic progenitor assays to test effects of new compounds on normal cellular function.
  • In Vivo Dose Range Finding: Develop a rational dosing regimen for testing efficacy of therapy
  • In Vivo Drug Efficacy/Tumor Xenograft Model: Establish tumors and administer drug regimen
  • Cellular Therapies: Irradiation of mice prior to transplantation, Intravenous injection of hematopoietic stem cells.
Categories for this Core: Keywords for this Core:
animal models, cancer models, in vivo, pre-clinical, rat, mouse, rodent, tumor xenograft, ectopic, orthotopic, pharmacokinetics, pharmacodynamics, MTD, LD 50

Contact Information:
Tony Sinn
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By |2019-04-01T17:11:52-04:00October 21st, 2018|Comments Off on In Vivo Therapeutics Core

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