Transgenic and Genome Editing Facility (TGEF)

Purdue University

Judy Hallett

https://www.purdue.edu/discoverypark/bioscience/facilities/core/transgenic/index.php

The TGEF Shared Resource is a state-of-the-art facility that offers a large number of services, including the creation of transgenic, gene knock-in and knock-out mouse and rat models for gain-of-function and loss-of-function experiments. Model systems based on transgenic and knock-in/knock-out strategies provide approaches that are developmentally, anatomically and physiologically relevant to human disease, and that can supplement traditional xenograft models for testing new anti-cancer therapies. Genome-edited animal models provide valuable reagents for studies ranging from the regulatory mechanisms governing gene expression patterns to cell-cell interactions, cell cycle control and regulation of signal transduction pathways.

• Transgenic and Genome Editing Facility Policies

• Mouse/Rat Transgenic Production

• Mouse/Rat CRISPR-mediated Knock Out Production

• Mouse/Rat CRISPR-mediated Knock In Production

• Mouse/Rat Embryo and Sperm Cryopreservation

• Mouse IVF

• Mouse/Rat Strain Rederivation

• Judy Hallett : halletje@purdue.edu (765) 496-3352