Transgenic and Genome Editing Facility (TGEF)

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Transgenic and Genome Editing Facility (TGEF)

Transgenic and Genome Editing Facility (TGEF)

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Purdue University


Judy Hallett


The TGEF Shared Resource is a state-of-the-art facility that offers a large number of services, including the creation of transgenic, gene knock-in and knock-out mouse and rat models for gain-of-function and loss-of-function experiments. Model systems based on transgenic and knock-in/knock-out strategies provide approaches that are developmentally, anatomically and physiologically relevant to human disease, and that can supplement traditional xenograft models for testing new anti-cancer therapies. Genome-edited animal models provide valuable reagents for studies ranging from the regulatory mechanisms governing gene expression patterns to cell-cell interactions, cell cycle control and regulation of signal transduction pathways.

  • Mouse/Rat Transgenic Production

  • Mouse/Rat CRISPR-mediated Knock Out Production

  • Mouse/Rat CRISPR-mediated Knock In Production

  • Mouse/Rat Embryo and Sperm Cryopreservation

  • Mouse IVF

  • Mouse/Rat Strain Rederivation

|2023-11-21T10:25:48-05:00November 21st, 2023|Comments Off on Transgenic and Genome Editing Facility (TGEF)

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