Clinical Pharmacology Analytical Core (CPAC)

IU Indianapolis

Zeruesenay Desta, Ph.D.

Sara Quinney, PharmD, Ph.D.

https://cancer.iu.edu/research/shared-facilities/cpac.html

Detailed understanding of drug disposition and factors affecting this process is important to guide preclinical drug discovery and development and in optimizing available drug therapies. CPAC specifically focuses on providing scientific and technical services to help investigators in their preclinical and clinical drug metabolism and pharmacokinetic studies. 

CPAC provides investigators with detailed information on in vivo pharmacokinetics (PK), drug interactions, in vitro drug metabolic stability, formulation optimization, protein binding, drug purity verification, and drug stability.

CPAC is the only analytical core on campus that offers a unique combination of extensive expertise on in vitro and in vivo drug metabolism, including stereoselective metabolism, drug-drug interactions, and pharmacokinetics (PK).

CPAC plays an essential role in this process by developing and supporting in vitro metabolic assays, formulation development, and the development and characterization of robust analytical methods to measure both the quantity and identity of drug molecules in a wide variety of biological and chemical matrices (plasma, urine, tissues, media, etc.).

• CPAC Policies
• CPAC Project Authorization Form

• Method development to quantify small molecules (drugs, metabolites, and new chemical entities) from a wide range of biological matrices utilizing HPLC-MS/MS

• Drug purity verification and stability

• In vitro metabolic stability

• Formulation solubility and stability

• Protein binding

• In vivo pharmacokinetics

• Non compartmental analysis

• LogP and LogD

• Thermodynamic Solubility

• Simulated fluid solubility

• Sara Quinney, PharmD, Ph.D. : Scientific Director/Advisor 317-274-2796