Clinical Pharmacology Analytical Core (CPAC)

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Clinical Pharmacology Analytical Core (CPAC)

Affiliation :  IU-Indianapolis

Core Director:   Andi Masters, M.S.
Scientific Director:   Zeruesenay Desta, Ph.D.


Detailed understanding of drug disposition and factors affecting this process is important to guide preclinical drug discovery and development and in optimizing available drug therapies. Established in 2004, the mission of the Clinical Pharmacology Analytical Core (CPAC) is to facilitate the research and development of drugs, metabolites, and new chemical entities (NCEs) in support of CTSI and IUSCC investigators with fast, accurate, publishable quality data, and cost effective services. CPAC exists to exceed investigators expectations of an analytical laboratory. CPAC specifically focuses on providing scientific and technical services to help investigators in their preclinical and clinical drug metabolism and pharmacokinetic studies. To support these activities, CPAC utilizes state-of-the art LC-MS/MS methods to quantify small molecules (drugs, metabolites, and new chemical entities) from a wide variety of biological samples (plasma, urine, tissues, media, etc.). CPAC provides investigators with detailed information on in vivo pharmacokinetics (PK), drug interactions, in vitro drug metabolic stability, formulation optimization, protein binding, drug purity verification, and drug stability. CPAC offers a unique combination of extensive expertise on in vitro and in vivo drug metabolism, including stereoselective metabolism, drug-drug interactions, and pharmacokinetics (PK), coupled to an infrastructure that provide multifaceted bioanalytical services in expedited time lines and with a high standard of quality.

Policies: Contact Information:
Andi Masters
Email This Core
(317) 274-3053

|2020-07-14T10:49:42-04:00July 14th, 2020|Comments Off on Clinical Pharmacology Analytical Core (CPAC)

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