Clinical Pharmacology Analytical Core (CPAC)

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Clinical Pharmacology Analytical Core (CPAC)

Clinical Pharmacology Analytical Core (CPAC)

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Core Director:

Lais da Silva, PhD

Scientific Director:

Zeruesenay Desta, Ph.D.


Detailed understanding of drug disposition and factors affecting this process is important to guide preclinical drug discovery and development and in optimizing available drug therapies. CPAC specifically focuses on providing scientific and technical services to help investigators in their preclinical and clinical drug metabolism and pharmacokinetic studies. To support these activities, CPAC utilizes state-of-the-art LC-MS/MS methods to quantify small molecules (drugs, metabolites, and new chemical entities) from a wide variety of biological samples (plasma, urine, tissues, media, etc.). CPAC provides investigators with detailed information on in vivo pharmacokinetics (PK), drug interactions, in vitro drug metabolic stability, formulation optimization, protein binding, drug purity verification, and drug stability. CPAC is the only analytical core on campus that offers a unique combination of extensive expertise on in vitro and in vivo drug metabolism, including stereoselective metabolism, drug-drug interactions, and pharmacokinetics (PK).

  • Method development to quantify small molecules (drugs, metabolites, and new chemical entities) from a wide range of biological matrices utilizing HPLC-MS/MS

  • Drug purity verification and stability

  • In vitro metabolic stability

  • Formulation solubility and stability

  • Protein binding

  • In vivo pharmacokinetics

  • Non compartmental analysis

  • LogP and LogD

  • Thermodynamic Solubility

  • Simulated fluid solubility

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|2023-11-21T10:25:48-05:00November 21st, 2023|Comments Off on Clinical Pharmacology Analytical Core (CPAC)

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