Servicecore – Do not remove

Clinical Pharmacology Analytical Core (CPAC)



Core Image

Affiliation :  IU-Indianapolis

Core Director:   Andi Masters, M.S.
Scientific Director:   Zeruesenay Desta, Ph.D.

Website:  http://cancer.iu.edu/research/facilities/clinical_pharma

Description:
Detailed understanding of drug disposition and factors affecting this process is important to guide preclinical drug discovery and development and in optimizing available drug therapies. CPAC specifically focuses on providing scientific and technical services to help investigators in their preclinical and clinical drug metabolism and pharmacokinetic studies. To support these activities, CPAC utilizes state-of-the-art LC-MS/MS methods to quantify small molecules (drugs, metabolites, and new chemical entities) from a wide variety of biological samples (plasma, urine, tissues, media, etc.). CPAC provides investigators with detailed information on in vivo pharmacokinetics (PK), drug interactions, in vitro drug metabolic stability, formulation optimization, protein binding, drug purity verification, and drug stability. CPAC is the only analytical core on campus that offers a unique combination of extensive expertise on in vitro and in vivo drug metabolism, including stereoselective metabolism, drug-drug interactions, and pharmacokinetics (PK).

Policies: Services Offered:
  • Method development to quantify small molecules (drugs, metabolites, and new chemical entities) from a wide range of biological matrices utilizing HPLC-MS/MS
  • Drug purity verification and stability
  • In vitro metabolic stability
  • Formulation solubility and stability
  • Protein binding
  • In vivo pharmacokinetics
  • Non compartmental analysis
Contact Information:
Andi Masters
Email This Core
(317) 274-3053

|2021-04-07T12:52:22-04:00April 7th, 2021|Comments Off on Clinical Pharmacology Analytical Core (CPAC)

Get Involved with Indiana CTSI