Biological Evaluation (BE-SR)

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Affiliation:

Purdue University

Director:

Dr. Bennett Elzey

Manager:

Sandra Torregrosa-Allen

Website:

https://purdue.ilabsolutions.com/service_center/show_external/4017

Description:

The mission of the Biological Evaluation Shared Resource (BE-SR) is to provide expert guidance to investigators in grant preparation, model selection and experimental design, and to perform toxicity testing and proof-of-concept efficacy studies for the advancement of their projects using in vivo testing.

Policies:
Services:
  • Xenograft and Syngeneic models:
    – Subcutaneous, intraperitoneal, intracardiac and intravenous Tumor Model Implantation
    – Orthotopic Tumor Models: Bladder, pancreas, prostate, kidney subrenal capsule, intracranial, breast fat pad,
  • PDX models
  • Efficacy Studies
    – Mouse weight
    – Tumor size monitored by caliper measurements for subcutaneous models and/or in vivo imaging for orthotopic or disseminated models
  • Intracranial Tumor Implantation
  • Toxicity Study, Maximum-Tolerated Dose (MTD) and Pharmacokinetic (PK) Studies
  • Drug administration: intravenously (IV), intramuscularly (IM), intraperitonealy (IP), and subcutaneously (SC), Intratracheal instillation, by food and/or drinking water
  • In Vivo Imaging studies:
    – IVIS Caliper bioluminescence and fluorescence
    – Micro CT
    – Ultrasound
    – Euthanasia, necropsy with organ and tissue collection
    – Blood draw including cardiac and retro-orbital
  • PDX tumor maintenance and expansion
  • Cell culture
Contact: