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Biological Evaluation (BE-SR)
Biological Evaluation (BE-SR)
Affiliation : Purdue University
Director:
Dr. Bennett Elzey
Manager:
Sandra Torregrosa-Allen
Website: https://purdue.ilabsolutions.com/service_center/show_external/4017
Description:
The mission of the Biological Evaluation Shared Resource (BE-SR) is to provide expert guidance to investigators in grant preparation, model selection and experimental design, and to perform toxicity testing and proof-of-concept efficacy studies for the advancement of their projects using in vivo testing.
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Xenograft and Syngeneic models:
– Subcutaneous, intraperitoneal, intracardiac and intravenous Tumor Model Implantation
– Orthotopic Tumor Models: Bladder, pancreas, prostate, kidney subrenal capsule, intracranial, breast fat pad, - PDX models
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Efficacy Studies
– Mouse weight
– Tumor size monitored by caliper measurements for subcutaneous models and/or in vivo imaging for orthotopic or disseminated models - Intracranial Tumor Implantation
- Toxicity Study, Maximum-Tolerated Dose (MTD) and Pharmacokinetic (PK) Studies
- Drug administration: intravenously (IV), intramuscularly (IM), intraperitonealy (IP), and subcutaneously (SC), Intratracheal instillation, by food and/or drinking water
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In Vivo Imaging studies:
– IVIS Caliper bioluminescence and fluorescence
– Micro CT
– Ultrasound
– Euthanasia, necropsy with organ and tissue collection
– Blood draw including cardiac and retro-orbital
- PDX tumor maintenance and expansion
- Cell culture
Bennett D. Elzey, Ph.D.
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317-278-3449