Biological Evaluation (BE-SR)

Affiliation :  Purdue University

Director:   Dr. Bennett Elzey
Manager:   Sandra Torregrosa-Allen

Website:  https://purdue.ilabsolutions.com/service_center/show_external/4017

Description:
The mission of the Biological Evaluation Shared Resource (BE-SR) is to provide expert guidance to investigators in grant preparation, model selection and experimental design, and to perform toxicity testing and proof-of-concept efficacy studies for the advancement of their projects using in vivo testing.

Policies:

• BE-SR Core Policies

Services Offered:

• Xenograft and Syngeneic models:
  – Subcutaneous, intraperitoneal, intracardiac and intravenous Tumor Model Implantation
  – Orthotopic Tumor Models: Bladder, pancreas, prostate, kidney subrenal capsule, intracranial, breast fat pad,
• PDX models
• Efficacy Studies
  – Mouse weight
  – Tumor size monitored by caliper measurements for subcutaneous models and/or in vivo imaging for orthotopic or disseminated models
• In Vivo Hollow Fiber Model
• Toxicity Study, Maximum-Tolerated Dose (MTD) and Pharmacokinetic (PK) Studies
• Drug administration: intravenously (IV), intramuscularly (IM), intraperitonealy (IP), and subcutaneously (SC), Intratracheal instillation, by food and/or drinking water
• In Vivo Imaging studies:
  – IVIS Caliper bioluminescence and fluorescence
  – Micro CT
  – Ultrasound
  – Euthanasia, necropsy with organ and tissue collection
  – Blood draw including cardiac and retro-orbital
  
• PDX tumor maintenance and expansion
• Cell culture

Contact Information:
Sandra Torregrosa-Allen, MS
Email This Core
765-496-0212