Biological Evaluation (BE-SR)

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Biological Evaluation (BE-SR)

Biological Evaluation (BE-SR)

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Purdue University


Dr. Bennett Elzey


Sandra Torregrosa-Allen


The mission of the Biological Evaluation Shared Resource (BE-SR) is to provide expert guidance to investigators in grant preparation, model selection and experimental design, and to perform toxicity testing and proof-of-concept efficacy studies for the advancement of their projects using in vivo testing.

  • Xenograft and Syngeneic models:
    – Subcutaneous, intraperitoneal, intracardiac and intravenous Tumor Model Implantation
    – Orthotopic Tumor Models: Bladder, pancreas, prostate, kidney subrenal capsule, intracranial, breast fat pad,

  • PDX models

  • Efficacy Studies
    – Mouse weight
    – Tumor size monitored by caliper measurements for subcutaneous models and/or in vivo imaging for orthotopic or disseminated models

  • Intracranial Tumor Implantation

  • Toxicity Study, Maximum-Tolerated Dose (MTD) and Pharmacokinetic (PK) Studies

  • Drug administration: intravenously (IV), intramuscularly (IM), intraperitonealy (IP), and subcutaneously (SC), Intratracheal instillation, by food and/or drinking water

  • In Vivo Imaging studies:
    – IVIS Caliper bioluminescence and fluorescence
    – Micro CT
    – Ultrasound
    – Euthanasia, necropsy with organ and tissue collection
    – Blood draw including cardiac and retro-orbital

  • PDX tumor maintenance and expansion

  • Cell culture

|2023-11-21T10:25:48-05:00November 21st, 2023|Comments Off on Biological Evaluation (BE-SR)

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