Service Cores

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Service Cores

Indiana CTSI Research Service Cores and Resources

The Indiana CTSI Research Service Cores and Resources are your aid to locate instrumentation and services suited to your research. A listing of a Core’s capabilities, contact information, and website address can be found by clicking their ‘Learn More’ button. All of the Designated Service Cores are eligible for CTSI Core Pilot grants and Post-Doc grants
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Purdue University

Non-Designated Service Resource

Bindley Bioscience Center

Biomolecular technologies, imaging and cytomics, bioinformatics support, and bionanotechnology with an emphasis on nanochemistry and functionalization of nanomaterials.

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Purdue University

Designated Service Core

Biological Evaluation (BE-SR)

The Biological Evaluation Shared Resource performs highly customizable efficacy testing of novel drug or therapies for antitumor activity. We also acquire blood or tissues for pharmacokinetic or pharmacodynamic analyses.

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Notre Dame

Designated Service Core

Biophysics Instrumentation Core (BIC) Facility

The BIC Facility offers sophisticated instrumentation dedicated to characterizing biomolecular conformations and interactions, as well as equipment for the isolation and purification of macromolecules for subsequent detailed biophysical analysis.

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IU Indianapolis

Designated Service Core

Biospecimen Collection and Banking Core

The IUSCCC Biospecimen Collection and Banking Core (BC2) provides an extensive collection of well-annotated samples from patients with malignancy and normal controls to support studies exploring the biologic basis of cancer, move basic findings to the clinic, and probe the biology underlying clinical and population phenomena. 

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IU Indianapolis

Designated Service Core

Biostatistics and Health Data Science Core

The Biostatistics and Health Data Science Core collaborates with investigators in the planning, statistical design, data management, and analysis of health related clinical, laboratory and epidemiological research projects. Grant development assistance is provided without charge.

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IU Indianapolis

Designated Service Core

Cellular Response Technologies Core

Conduct validated and highly reproducible in vitro and in vivo angiogenesis, endothelial, hematopoietic and multi-parametric flow cytometry assays and their role in normal and patient-related hematologic and cardiovascular disorders. The ABC also manages an IncuCyte Zoom and Seahorse XFp.

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Purdue University

Non-Designated Service Resource

Center for Comparative Translational Research

Translational research spans the continuum in which research findings from the researcher’s lab are moved to the patients ‘bedside’ (human) or ‘barn’ (animal). The Center for Comparative Translational Research (CTR) wants to make bridging the gap between benchtop and bedside/barn easier by helping researchers conduct comparative animal studies using induced and spontaneous disease models. It does so by facilitating, coordinating, integrating …

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IU Indianapolis

Designated Service Core

Chemical Genomics Core Facility

The CGCF is located in the Van Nuys Medical Science Building in Indianapolis. The core is equipped with five hoods for chemical synthesis, a microwave reactor, a parallel synthesizer and preparative HPLCs, LC-QTOF and 600 MHz NMR; a collection of 227,680 diversified small molecules, CRISPR libraries, liquid handling, assay detection and cell image systems.

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Purdue University

Designated Service Core

Chemical Genomics Facility (CGF)

The Chemical Genomics Facility (CGF) provides affordable access to large chemical and CRISPR libraries and state-of-the-art instrumentation in high-throughput screening (HTS) and high content screening (HCS) campaigns to facilitate the identification of chemical or genomic tools to study biological pathways and the discovery of lead agents for the development of novel therapeutics and diagnostic approaches. The facility also provides assistance in assay development and hit …

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Purdue University

Designated Service Core

Cryo-EM Facility

The Purdue Cryo-EM facility provides access to state-of-the-art instrumentation enabling users to collect data for high-resolution single particle reconstructions and tomographic studies of cells and larger complexes.

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IU Bloomington

Designated Service Core

Electron Microscopy Center (IUB-EMC)

The IU Bloomington Electron Microscopy Center (IUB-EMC) provides equipment, services and expertise for biological and material science electron microscopy.

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IU Indianapolis

Designated Service Core

Flow Cytometry Resource Facility (FCRF)

The Flow Cytometry Resource Facility (FCRF) provides flow cytometric analysis and cell sorting services as well as flow cytometric image analysis.

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IU Indianapolis

Designated Service Core

Histology and Histomorphometry Core (HHC)

Histology and Histomorphetry Core (HHC) provides histological and histomorphometric services for basic science (non-clinical) research. Mineralized (plastic embedded), soft tissue (paraffin embedded), and cryopreserved specimens can be processed by the facility.

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Purdue University

Designated Service Core

Histology Research Laboratory (HRL)

The Histology Research Laboratory is a full service histology laboratory that provides general histology, immunohistochemistry, frozen sectioning, decalcified and undecalcified bone histology, and slide digitization services. Board certified veterinary pathologists are also available for consultation.

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IU Indianapolis

Non-Designated Service Resource

Human Vascular Imaging Core (HVIC)

The HVIC performs functional and anatomic vascular imaging measuremetns (flow-mediated dilation and carotid intima-media thickness).

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IUSM South Bend

Designated Service Core

Imaging and Flow Cytometry Core Facility

Standard confocal or multiphoton resources for imaging live or fixed samples and a 5 color flow cytometric analyzer are available. Data analysis software for each resource is also available on site.

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Purdue University

Designated Service Core

Imaging Facility

The Bioscience Imaging Facility, Purdue University, is a 24hr/7day access core facility specializing in confocal microscopy, multi-photon and light sheet microscopy, pre-clinical molecular and nuclear imaging and computed tomography (mCT) with offline analysis workstations.

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IU Bloomington

Designated Service Core

Imaging Research Facility (IRF)

The IRF is a state-of-the-art neuroimaging facility that enables cutting-edge neuroscience research and training using non-invasive imaging methodologies, including both MRI and EEG.

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IU Indianapolis

Designated Service Core

In Vivo Therapeutics Core (IVT)

The In Vivo Therapeutics Core (IVTC) supports the research and development of safe and more efficacious drug treatment. The IVTC provides cost-effective and comprehensive services including, but not limited to, on-site breeding facilities as well as a numerous in vivo pharmacology models to facilitate the development and testing of novel pharmacological & cellular therapies.

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IU Indianapolis

Designated Service Core

In-Vivo Imaging Core

The In-Vivo Imaging Core provides imaging services for clinical trials, observational, and preclinical studies. We also provide radiochemistry support for molecular imaging. Currently, the Imaging Core is equipped with state-of-the-art imaging systems, including 3T MRI scanners, PET-CT scanners, Bruker 9.4 T preclinical PET-MRI scanner, a Siemens Eclipse Medical Cyclotron, and Radiochemistry Facilities. Highly skilled faculty and staff are available to assist with research …

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IU Indianapolis

Designated Service Core

Indiana Center for Biological Microscopy (ICBM)

The ICBM provides researchers with access to laser-scanning confocal, 2-photon and epi-fluorescence microscopes (http://www.medicine.iupui.edu/ICBM/USING-THE-FACILITY).  Center personnel train individual researchers to use all imaging systems and provide expert help in the design, conduct and analysis of imaging studies.  As necessary, center personnel can also be hired to conduct microscopy studies for laboratories lacking the necessary expertise.

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Notre Dame

Designated Service Core

Integrated Imaging Facility (NDIIF)

The Notre Dame Integrated Imaging Facility (NDIIF) is a state-of-the-art research core that makes available to the Notre Dame science and engineering community, as well as external customers, an integrated suite of sophisticated microscopes and imaging stations. The NDIIF also provides resident professional staff (three Ph.D.-level imaging specialists and two technicians) to guide the non-expert users. 

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Notre Dame

Designated Service Core

Integrated Imaging Facility – Histology Core (NDHC)

The Notre Dame Histology Core (NDHC) provides a means to examine biological processes in mice, rats, frogs, zebra fish, fruit flies, sheep bone, and even human tissue by use of immunohistochemical techniques and pathology.

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IU Indianapolis

Designated Service Core

Islet and Physiology Core

The Islet and Physiology Core of the Center for Diabetes and Metabolic Diseases provides investigators with the capability to obtain high quality rodent pancreatic islets for study.  The Core also provides services for islet transplantation and will assist investigators who wish to perform immunohistochemistry, immunofluorescence, and/or analysis of beta cell mass on whole pancreata from mouse and rat models. 

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IU Indianapolis

Designated Service Core

IU School of Medicine Center for Electron Microscopy (iCEM)

The Indiana University School of Medicine Electron Microscopy Center is a full service research laboratory providing both Transmission and Scanning Electron Microscopy. The service provided can apply both traditional methods and recent technical developments to suit the investigator’s needs.

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Purdue University

Non-Designated Service Resource

Life Science Microscopy Facility

The Life Science Microscopy Facility (LSMF) is an electron microscopy core with both service and individual use options.

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IU Bloomington

Designated Service Core

Light Microscopy Imaging Center (LMIC)

The LMIC provides access and training for confocal and super-resolution light microscopy systems with support for experimental design and data visualization.

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IU Bloomington

Designated Service Core

Macromolecular Crystallography Facility Integrated with the Crystallization Automation Facility (MCF/CAF)

The Macromolecular X-ray Crystallography Facility provides all resources for Crystal Screening and Optimization, Data Collection and Structure Determination of macromolecules.

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IU Bloomington

Non-Designated Service Resource

Mass Spectrometry Facility

The Indiana University Mass Spectrometry Facility (MSF) provides qualitative and quantitative small molecule mass spectrometry data. It also confirms chemical formulae of novel compounds by accurate mass spectrometry.

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Notre Dame

Non-Designated Service Resource

Molecular Structure Facility

The Molecular Structure Facility at the University of Notre Dame provides for X-Ray structural studies of small (ca. 2kDa) molecules. The Facility has the capability to examine a wide range of molecules from “light atom” biologically relevant to metal-complexed compounds which can be readily analyzed using non-destructive techniques.

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Purdue University

Designated Service Core

Pre-Clinical Research Laboratory (PCL)

The Pre-Clinical Research Laboratory (PCL) helps researchers conduct pre-clinical animal research by providing research expertise, technical support, surgical experience, and surgical facilities and equipment. The PCL is a multidisciplinary laboratory where researchers conduct advanced clinical and applied research using induced animal models ranging from rodents to pigs and sheep

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IU Indianapolis

Non-Designated Service Resource

Preclinical Innovation Think Tanks

Indiana CTSI Think Tanks are an opportunity for researchers at any of the Indiana CTSI campuses of Indiana University (IU), Purdue University and the University of Notre Dame to get help advancing their discoveries to the market. The Drug and Device Think Tanks each serve as a one-stop shop where investigators can receive guidance from a pool of advisors with a wide range of scientific, technical, clinical, business, and regulatory expertise.

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IU Indianapolis

Designated Service Core

Preclinical Modeling and Therapeutics Core (PMTC)

The Preclinical Modeling and Therapeutics Core (PMTC) facilitates the development of pharmacological and cellular therapies for cancer. It provides advanced resources essential for the preclinical validation of novel drug targets and biomarkers of cancer. The PMTC provides expertise in:
• Cellular response technologies
• Breeding of specialized mouse strains
• Tumor modeling
• In vivo therapeutics efficacy & safety testing
• …

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Purdue University

Designated Service Core

Purdue MRI Facility

The Purdue MRI Facility houses two 3T full body MRI systems and one 7T small bore (animal) MRI system that are available for research involving MRI, MR spectroscopy, and other MR applications.

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Purdue University

Non-Designated Service Resource

Veterinary Clinical Trials (VCT)

The Veterinary Clinical Trials Support Service (VCT) facilitates veterinary clinical trials and provides expertise and technical support for translational clinical investigations using animal models of spontaneous, naturally-occurring diseases in client-owned animals and for trials leading to novel drugs or devices.

|2024-03-25T10:44:53-04:00March 25th, 2024|Comments Off on Service Cores

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