Service Cores

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Service Cores

Indiana CTSI Research Service Cores and Resources

The Indiana CTSI Research Service Cores and Resources are your aid to locate instrumentation and services suited to your research. A listing of a Core’s capabilities, contact information, and website address can be found by clicking their ‘Learn More’ button. All of the Designated Service Cores are eligible for CTSI Core Pilot grants and Post-Doc grants
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Purdue University

Non-Designated Service Resource

Bindley Bioscience Center

Biomolecular technologies, imaging and cytomics, bioinformatics support, and bionanotechnology with an emphasis on nanochemistry and functionalization of nanomaterials.

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Purdue University

Designated Service Core

Biological Evaluation (BE-SR)

The Biological Evaluation Shared Resource performs highly customizable efficacy testing of novel drug or therapies for antitumor activity. We also acquire blood or tissues for pharmacokinetic or pharmacodynamic analyses.

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Notre Dame

Designated Service Core

Biophysics Instrumentation Core (BIC) Facility

The BIC Facility offers sophisticated instrumentation dedicated to characterizing biomolecular conformations and interactions, as well as equipment for the isolation and purification of macromolecules for subsequent detailed biophysical analysis.

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IU Indianapolis

Designated Service Core

Biostatistics and Health Data Science Core

The Biostatistics and Health Data Science Core collaborates with investigators in the planning, statistical design, data management, and analysis of health related clinical, laboratory and epidemiological research projects. Grant development assistance is provided without charge.

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IU Indianapolis

Non-Designated Service Resource

Cell and Gene Therapy Manufacturing

The Cell and Gene Therapy Manufacturing (CGTM) Facility collaborates with investigators through all phases of cell and gene therapy manufacturing, from pre-clinical design through treatment of patients. The facility is under the direction of Emily Hopewell, PhD, and comprises the Cell Immunotherapy and Transduction Facility (CIT), the Vector Production Facility (VPF), and the Bioprocess Development and Cell Manufacturing Lab (BDL). Each section of the CGTM is led by a …

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Purdue University

Non-Designated Service Resource

Center for Comparative Translational Research

Translational research spans the continuum in which research findings from the researcher’s lab are moved to the patients ‘bedside’ (human) or ‘barn’ (animal). The Center for Comparative Translational Research (CTR) wants to make bridging the gap between benchtop and bedside/barn easier by helping researchers conduct comparative animal studies using induced and spontaneous disease models. It does so by facilitating, coordinating, integrating …

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IU Indianapolis

Designated Service Core

Chemical Genomics Core Facility

The CGCF is located in the Van Nuys Medical Science Building in Indianapolis. The core is equipped with five hoods for chemical synthesis, a microwave reactor, a parallel synthesizer and preparative HPLCs, LC-QTOF and 600 MHz NMR; a collection of 227,680 diversified small molecules, CRISPR libraries, liquid handling, assay detection and cell image systems.

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Purdue University

Designated Service Core

Chemical Genomics Facility (CGF)

The Chemical Genomics Facility (CGF) provides affordable access to large chemical and CRISPR libraries and state-of-the-art instrumentation in high-throughput screening (HTS) and high content screening (HCS) campaigns to facilitate the identification of chemical or genomic tools to study biological pathways and the discovery of lead agents for the development of novel therapeutics and diagnostic approaches. The facility also provides assistance in assay development and hit …

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IU Indianapolis

Designated Service Core

Clinical Pharmacology Analytical Core (CPAC)

The Clinical Pharmacology Analytical core provides drug and metabolite concentrations from a variety of biological matrices such as (but not limited to): plasma, urine, CSF, and tissue using HPLC-MS/MS. Additional services include protein binding of drugs, formulation studies, drug stability, drug metabolism, and metabolite screening.

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Purdue University

Designated Service Core

Cryo-EM Facility

The Purdue Cryo-EM facility provides access to state-of-the-art instrumentation enabling users to collect data for high-resolution single particle reconstructions and tomographic studies of cells and larger complexes.

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IU Indianapolis

Designated Service Core

Flow Cytometry Resource Facility (FCRF)

The Flow Cytometry Resource Facility (FCRF) provides flow cytometric analysis and cell sorting services as well as flow cytometric image analysis.

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IU Indianapolis

Designated Service Core

Histology and Histomorphometry Core (HHC)

Histology and Histomorphetry Core (HHC) provides histological and histomorphometric services for basic science (non-clinical) research. Mineralized (plastic embedded), soft tissue (paraffin embedded), and cryopreserved specimens can be processed by the facility.

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IU Indianapolis

Non-Designated Service Resource

Human Vascular Imaging Core (HVIC)

The HVIC performs functional and anatomic vascular imaging measuremetns (flow-mediated dilation and carotid intima-media thickness).

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IUSM South Bend

Designated Service Core

Imaging and Flow Cytometry Core Facility

Standard confocal or multiphoton resources for imaging live or fixed samples and a 5 color flow cytometric analyzer are available. Data analysis software for each resource is also available on site.

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Purdue University

Designated Service Core

Imaging Facility

The Bioscience Imaging Facility, Purdue University, is a 24hr/7day access core facility specializing in confocal microscopy, multi-photon and light sheet microscopy, pre-clinical molecular and nuclear imaging and computed tomography (mCT) with offline analysis workstations.

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IU Bloomington

Designated Service Core

Imaging Research Facility (IRF)

The IRF is a state-of-the-art neuroimaging facility that enables cutting-edge neuroscience research and training using non-invasive imaging methodologies, including both MRI and EEG.

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IU Indianapolis

Designated Service Core

In Vivo Therapeutics Core (IVT)

The In Vivo Therapeutics Core (IVTC) supports the research and development of safe and more efficacious drug treatment. The IVTC provides cost-effective and comprehensive services including, but not limited to, on-site breeding facilities as well as a numerous in vivo pharmacology models to facilitate the development and testing of novel pharmacological & cellular therapies.

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IU Indianapolis

Designated Service Core

In-Vivo Imaging Core

The In-Vivo Imaging Core provides imaging services for clinical trials, observational, and preclinical studies. We also provide radiochemistry support for molecular imaging. Currently, the Imaging Core is equipped with state-of-the-art imaging systems, including 3T MRI scanners, PET-CT scanners, Bruker 9.4 T preclinical PET-MRI scanner, a Siemens Eclipse Medical Cyclotron, and Radiochemistry Facilities. Highly skilled faculty and staff are available to assist with research …

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IU Indianapolis

Designated Service Core

Indiana Center for Biological Microscopy (ICBM)

The ICBM provides researchers with access to laser-scanning confocal, 2-photon and epi-fluorescence microscopes (http://www.medicine.iupui.edu/ICBM/USING-THE-FACILITY).  Center personnel train individual researchers to use all imaging systems and provide expert help in the design, conduct and analysis of imaging studies.  As necessary, center personnel can also be hired to conduct microscopy studies for laboratories lacking the necessary expertise.

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Notre Dame

Designated Service Core

Integrated Imaging Facility (NDIIF)

The Notre Dame Integrated Imaging Facility (NDIIF) is a state-of-the-art research core that makes available to the Notre Dame science and engineering community, as well as external customers, an integrated suite of sophisticated microscopes and imaging stations. The NDIIF also provides resident professional staff (three Ph.D.-level imaging specialists and two technicians) to guide the non-expert users. 

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Notre Dame

Designated Service Core

Integrated Imaging Facility – Histology Core (NDHC)

The Notre Dame Histology Core (NDHC) provides a means to examine biological processes in mice, rats, frogs, zebra fish, fruit flies, sheep bone, and even human tissue by use of immunohistochemical techniques and pathology.

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IU Indianapolis

Designated Service Core

Islet and Physiology Core

The Islet and Physiology Core of the Center for Diabetes and Metabolic Diseases provides investigators with the capability to obtain high quality rodent pancreatic islets for study.  The Core also provides services for islet transplantation and will assist investigators who wish to perform immunohistochemistry, immunofluorescence, and/or analysis of beta cell mass on whole pancreata from mouse and rat models. 

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IU Indianapolis

Designated Service Core

IU School of Medicine Center for Electron Microscopy (iCEM)

The Indiana University School of Medicine Electron Microscopy Center is a full service research laboratory providing both Transmission and Scanning Electron Microscopy. The service provided can apply both traditional methods and recent technical developments to suit the investigator’s needs.

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Purdue University

Non-Designated Service Resource

Life Science Microscopy Facility

The Life Science Microscopy Facility (LSMF) is an electron microscopy core with both service and individual use options.

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IU Bloomington

Designated Service Core

Light Microscopy Imaging Center (LMIC)

The LMIC provides access and training for confocal and super-resolution light microscopy systems with support for experimental design and data visualization.

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IU Bloomington

Designated Service Core

Macromolecular Crystallography Facility Integrated with the Crystallization Automation Facility (MCF/CAF)

The Macromolecular X-ray Crystallography Facility provides all resources for Crystal Screening and Optimization, Data Collection and Structure Determination of macromolecules.

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IU Bloomington

Non-Designated Service Resource

Mass Spectrometry Facility

The Indiana University Mass Spectrometry Facility (MSF) provides qualitative and quantitative small molecule mass spectrometry data. It also confirms chemical formulae of novel compounds by accurate mass spectrometry.

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Purdue University

Designated Service Core

Pre-Clinical Research Laboratory (PCL)

The Pre-Clinical Research Laboratory (PCL) helps researchers conduct pre-clinical animal research by providing research expertise, technical support, surgical experience, and surgical facilities and equipment. The PCL is a multidisciplinary laboratory where researchers conduct advanced clinical and applied research using induced animal models ranging from rodents to pigs and sheep

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IU Indianapolis

Non-Designated Service Resource

Preclinical Innovation Think Tanks

Indiana CTSI Think Tanks are an opportunity for researchers at any of the Indiana CTSI campuses of Indiana University (IU), Purdue University and the University of Notre Dame to get help advancing their discoveries to the market. The Drug and Device Think Tanks each serve as a one-stop shop where investigators can receive guidance from a pool of advisors with a wide range of scientific, technical, clinical, business, and regulatory expertise.

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IU Indianapolis

Designated Service Core

Preclinical Modeling and Therapeutics Core (PMTC)

The Preclinical Modeling and Therapeutics Core (PMTC) facilitates the development of pharmacological and cellular therapies for cancer. It provides advanced resources essential for the preclinical validation of novel drug targets and biomarkers of cancer. The PMTC provides expertise in:
• Cellular response technologies
• Breeding of specialized mouse strains
• Tumor modeling
• In vivo therapeutics efficacy & safety testing
• …

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Purdue University

Designated Service Core

Purdue MRI Facility

The Purdue MRI Facility houses two 3T full body MRI systems and one 7T small bore (animal) MRI system that are available for research involving MRI, MR spectroscopy, and other MR applications.

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IU Indianapolis

Non-Designated Service Resource

SNRI Biomarker Core

The Stark Neurosciences Research Institute Biomarker Core provides biomarker services to investigators. Multiplexing of targets in tissues or on a slide, investigators can detect changes in their samples and target specific pathways of interest in disease. 

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Purdue University

Designated Service Core

Translational Pharmacology Facility

The PTP Core offers automated blood monitoring in rodents and large animals utilizing stress free sampling through CulexTM technology. We perform a host of services from early lead identification PK and PD assessment through product testing of human formulations in pigs and minipigs, including preclinical formulation development, biodistribution studies, metabolomics analysis, and in vivo toxicological evaluation.

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IU Indianapolis

Non-Designated Service Resource

Vector Production Facility (IUVPF)

IUVPF produces retroviral and lentiviral vectors for both pre-clinical and FDA Phase I/II human gene therapy clinical trials.

|2024-03-28T10:47:31-04:00March 28th, 2024|Comments Off on Service Cores

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