Service Cores

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Service Cores

Indiana CTSI Research Service Cores and Resources

The Indiana CTSI Research Service Cores and Resources are your aid to locate instrumentation and services suited to your research. A listing of a Core’s capabilities, contact information, and website address can be found by clicking their ‘Learn More’ button. All of the Designated Service Cores are eligible for CTSI Core Pilot grants and Post-Doc grants
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Purdue University

Non-Designated Service Resource

Bindley Bioscience Center

Biomolecular technologies, imaging and cytomics, bioinformatics support, and bionanotechnology with an emphasis on nanochemistry and functionalization of nanomaterials.

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Purdue University

Non-Designated Service Resource

Bioinformatics Core

The Bioinformatics Core provides data analysis services for genomics, proteomics and metabolomics data.

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IU Indianapolis

Designated Service Core

Bioinformatics Core

The Bioinformatics Core provides advanced computation and informatics approaches to analyze large and complex biological datasets.

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IU Indianapolis

Designated Service Core

Biostatistics and Health Data Science Core

The Biostatistics and Health Data Science Core collaborates with investigators in the planning, statistical design, data management, and analysis of health related clinical, laboratory and epidemiological research projects. Grant development assistance is provided without charge.

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IU Indianapolis

Designated Service Core

Center for Medical Genomics (CMG)

The Center for Medical Genomics provides high-throughput genomics services including: genomic DNA sequencing, transcriptome RNA sequencing, miRNA sequencing, methylome or targeted methylation sequencing, protein DNA/RNA interaction (ChIP-seq, ATAC-seq and CLIP-seq), 10x single cell or single nuclei sequencing, and SNP genotyping.

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Purdue University

Designated Service Core

Chemical Genomics Facility (CGF)

The Chemical Genomics Facility (CGF) provides affordable access to large chemical and CRISPR libraries and state-of-the-art instrumentation in high-throughput screening (HTS) and high content screening (HCS) campaigns to facilitate the identification of chemical or genomic tools to study biological pathways and the discovery of lead agents for the development of novel therapeutics and diagnostic approaches. The facility also provides assistance in assay development and hit …

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IU Indianapolis

Designated Service Core

Clinical Pharmacology Analytical Core (CPAC)

The Clinical Pharmacology Analytical core provides drug and metabolite concentrations from a variety of biological matrices such as (but not limited to): plasma, urine, CSF, and tissue using HPLC-MS/MS. Additional services include protein binding of drugs, formulation studies, drug stability, drug metabolism, and metabolite screening.

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Purdue University

Designated Service Core

Flow Cytometry and Cell Sorting Facility

The Purdue Flow Cytometry Core Facility provides instrumentation, data analysis software, training and technical expertise for flow cytometry analysis and cell sorting. Our capabilities also include the characterization of genome and transcriptomes using the Fluidigm C1 and 10X Genomics systems, in partnership with the Purdue Genomics Core Facility.

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IU Indianapolis

Designated Service Core

Flow Cytometry Resource Facility (FCRF)

The Flow Cytometry Resource Facility (FCRF) provides flow cytometric analysis and cell sorting services as well as flow cytometric image analysis.

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Notre Dame

Designated Service Core

Genomics and Bioinformatics Core Facility (GBCF)

The Genomics & Bioinformatics Core Facility (GBCF) at the University of Notre Dame offers comprehensive services and support for state-of-the-art genomics experiments and bioinformatics analysis. This includes next generation Illumina sequencing, a variety of standard and specialty DNA and RNA library construction methods, consultation, and analysis support.

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IU Indianapolis

Designated Service Core

In-Vivo Imaging Core

The In-Vivo Imaging Core provides imaging services for clinical trials, observational, and preclinical studies. We also provide radiochemistry support for molecular imaging. Currently, the Imaging Core is equipped with state-of-the-art imaging systems, including 3T MRI scanners, PET-CT scanners, Bruker 9.4 T preclinical PET-MRI scanner, a Siemens Eclipse Medical Cyclotron, and Radiochemistry Facilities. Highly skilled faculty and staff are available to assist with research …

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IU Indianapolis

Non-Designated Service Resource

Investigational Agent Acquisition Program

Goal: The goal of the CTSI Investigational Agent Acquisition Program (IAAP) is to assist CTSI investigators seeking investigational agents for use in clinical trials.

Scope: The IAAP program will assist in acquiring drugs, neutraceuticals, biologics or other materials to be used in a Investigational New Drug Application or IND-exempt clinical trial.

Eligibility: Any faculty within the CTSI member institutions.

Overview: Moving bench research into …

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IU Bloomington

Designated Service Core

Laboratory for Biological Mass Spectrometry (LBMS)

The LBMS uses mass spectrometry to characterize proteins as well as other biologically-derived molecules. It specializes in the characterization of protein post-translational modifications, including glycosylation, phosphorylation, acetylation and persulfidation (S-sulfhydration). We also have an emphasis on identification of protein-interactions (including determination of protein-protein crosslinks) and quantitative comparisons of complex samples.

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IU Bloomington

Designated Service Core

Macromolecular Crystallography Facility Integrated with the Crystallization Automation Facility (MCF/CAF)

The Macromolecular X-ray Crystallography Facility provides all resources for Crystal Screening and Optimization, Data Collection and Structure Determination of macromolecules.

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Notre Dame

Designated Service Core

Mass Spectrometry and Proteomics Facility

Analysis of large and small molecules using several ionization methods, low or high resolution, hyphenated techniques, proteomics, and metabolomics.

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Purdue University

Designated Service Core

Metabolite Profiling Facility (MPF)

The Metabolite Profiling Facility (MPF) provides both qualitative (comparative analysis) and quantitative (absolute concentrations) metabolite chemical analysis in complex biological systems.

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IU Indianapolis

Designated Service Core

Multiplex Analysis Core (MAC)

The Multiplex Analysis Core (MAC) offers microplate-based immunoassay systems that can perform multiplex analysis of multiple different analytes in a single sample. The MAC uses a Bio-Plex 200 Multiplex System with High Throughput Fluidics based on Luminex technology.

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IU Bloomington

Non-Designated Service Resource

Physical and Biochemistry Instrumentation Facility (PBIF)

The PBIF provides resources to characterize particle properties as well as macromolecular interactions.

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IU Indianapolis

Non-Designated Service Resource

SNRI Biomarker Core

The Stark Neurosciences Research Institute Biomarker Core provides biomarker services to investigators. Multiplexing of targets in tissues or on a slide, investigators can detect changes in their samples and target specific pathways of interest in disease. 

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Purdue University

Designated Service Core

Translational Pharmacology Facility

The PTP Core offers automated blood monitoring in rodents and large animals utilizing stress free sampling through CulexTM technology. We perform a host of services from early lead identification PK and PD assessment through product testing of human formulations in pigs and minipigs, including preclinical formulation development, biodistribution studies, metabolomics analysis, and in vivo toxicological evaluation.

|2024-03-25T10:44:53-04:00March 25th, 2024|Comments Off on Service Cores

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