Disease & Therapeutic Response Modeling Program

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Disease & Therapeutic Response Modeling Program2018-10-23T17:55:09-04:00

Disease and Therapeutic Response Modeling and Simulation

Affiliation: Indiana University School of Medicine, Department of Medicine, Division of Clinical Pharmacology
Director: Robert E. Stratford, Jr.
Disease and therapeutic response modeling cuts across all therapeutic disciplines. The approach leverages in vitro and in vivo data to describe complex biological processes associated with disease and/or drug actions that alter disease. Applied to a specific disease and/or therapeutic initiative, modeling informs bench and bedside research to reduce costs and decision time, thereby improving research efficiency and treatment effectiveness. Data are at the heart of modeling and simulation research. These come from a variety of sources, including individual patient and population-level clinical data, genetic and ‘omics-level platform data, and computational and bioinformatics ‘big-data’ sources. Initial and continuous model development rely on a variety of modeling software platforms available within the Modeling and Simulation program, with platform choice tailored to the specific research problem.
Services Offered:

  • Consulting to enable sponsor-driven basic descriptive pharmacokinetic (PK) and pharmacodynamics (PD) data analyses through publically available analysis software
  • Developing non-clinical, translational and/or clinical PK/PD models
  • Training pre-doctoral, post-doctoral and faculty-level scientists in specific modeling competencies to increase the capacity for PK and PK/PD modeling
  • Making models publically available through the CTSA Consortium

Keywords: modeling, pharmacokinetics, pharmacodynamics, PK/PD, pre-clinical, translational

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