Weekly Review: Clinical Studies – August 17, 2020
Personal Protective Equipment
A quality improvement study looking at comparative fitted filtration efficiencies for various mask styles found N95 makes had efficiencies of 98.%; surgical mask with ties was 71.5%; procedure mask with ear loops was 38.1%. Used and/or expired N95s are still more effective than alternative mask options.
In a survey of pediatric tertiary care hospital physicians, residents, nurses, respiratory therapists and others: Only 50% knew the correct donning order and 35% knew the correct doffing order. Healthcare institutions should have ongoing trainings for healthcare works that focus on appropriate personal protective equipment and discussions around modes of transmission of COVID-19.
A phase 1/2 study of COVID-19 RNA vaccine BNT16261 in adults had acceptable levels of adverse reactions upon administration of one of the two planned doses. Vaccine had good immunological response.
Within an interim analysis of 2 randomized placebo-controlled trials (Phases 1/2) of an inactivated whole-virus COVID-19 vaccine in China, they found it had low rates of adverse reactions and demonstrated immunogenicity.
In a case-control study, icatibant (a bradykinin 2 receptor antagonist) treatment was associated with improved oxygenation in patients w/ severe COVID-19 pulmonary disease.
About the Author: Megan McHenry
Megan S. McHenry, MD, MS, FAAP is a pediatrician and an Assistant Professor of Pediatrics in the Ryan White Center for Pediatric Infectious Disease and Global Health at Indiana University School of Medicine. Dr. McHenry's research focuses on early childhood development in children living in resource-limited settings. This work is frequently aligned with community-engaged research and dissemination and implementation science frameworks. She primarily conducts research in collaboration with the Academic Model for Providing Access to Healthcare (AMPATH) Research Network in Kenya. Dr. McHenry currently has a career development award through the National Institutes of Health to develop a neurodevelopmental screening program for children born to HIV-infected mothers in Kenya.
Dr. McHenry is also the Director of Pediatric Global Health Education and a co-Director of the Morris Green Physician-Scientist Development Program at Indiana University School of Medicine. In additional to global health lectures, she also educates residents and students on early childhood development, basic biostatistical techniques, research methodologies, and research ethics. She mentors multiple pediatric fellows, residents, and medical students interested in early childhood development within global contexts.