Weekly Review: Clinical Studies – September 21, 2020

Weekly Review: Clinical Studies – September 21, 2020

Clinical Characteristics:

Within this surveillance cohort of 598 hospitalized pregnant women with COVID-19, 55% were asymptomatic at admission. Among these pregnant women, 2% had pregnancy losses during COVID-19-associated hospitalizations and were experienced by both symptomatic and asymptomatic women.

Inflammation:

Within this cross-sectional study of 115 consecutive COVID-19 patients with both non-severe (n=71) and severe (n=44) symptoms, platelets were found to associate with SARS-CoV-2 RNA and were hyper-activated in both non-severe and severe forms of COVID-19. Levels of D-dimer (a marker of thrombosis) failed to correlate with this platelet activation. This study suggests that platelets are at the frontline of COVID-19 parthenogenesis and may contribute to the overwhelming thrombo-inflammation in COVID-19.

Transmission:

Within this cross-sectional study, 50 cats of households or close contacts with COVID-19 in Hong Kong were tested for COVID-19. Six cases of apparent human-to-feline transmission were found involving healthy cats, with identical viral genomes between one owner and cat.

Cochrane Reviews:

Three Cochrane Reviews were published on the use of antimicrobial mouthwashes (gargling) and nasal sprays in three different populations:

  • Review 1: For healthcare workers when undertaking aerosol‐generating procedures (AGPs) on patients without suspected or confirmed COVID‐19 infection
    • No articles were found on this topic.
  • Review 2: For patients with suspected or confirmed COVID‐19 infection to improve patient outcomes and to protect healthcare workers treating them
    • No completed studies on this topic, but identified 16 ongoing studies (including 14 randomized controlled trials (RCTs))
  • Review 3: For healthcare workers to protect them when treating patients with suspected or confirmed COVID‐19 infection
    • No completed studies on this topic, but identified 2 ongoing studies (including 2 RCTs)
|2020-09-21T07:45:25-04:00September 21st, 2020|COVID-19 Literature|Comments Off on Weekly Review: Clinical Studies – September 21, 2020

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