Weekly Review: Clinical Studies – September 21, 2020

Clinical Characteristics:

Within this surveillance cohort of 598 hospitalized pregnant women with COVID-19, 55% were asymptomatic at admission. Among these pregnant women, 2% had pregnancy losses during COVID-19-associated hospitalizations and were experienced by both symptomatic and asymptomatic women.


Within this cross-sectional study of 115 consecutive COVID-19 patients with both non-severe (n=71) and severe (n=44) symptoms, platelets were found to associate with SARS-CoV-2 RNA and were hyper-activated in both non-severe and severe forms of COVID-19. Levels of D-dimer (a marker of thrombosis) failed to correlate with this platelet activation. This study suggests that platelets are at the frontline of COVID-19 parthenogenesis and may contribute to the overwhelming thrombo-inflammation in COVID-19.


Within this cross-sectional study, 50 cats of households or close contacts with COVID-19 in Hong Kong were tested for COVID-19. Six cases of apparent human-to-feline transmission were found involving healthy cats, with identical viral genomes between one owner and cat.

Cochrane Reviews:

Three Cochrane Reviews were published on the use of antimicrobial mouthwashes (gargling) and nasal sprays in three different populations:

  • Review 1: For healthcare workers when undertaking aerosol‐generating procedures (AGPs) on patients without suspected or confirmed COVID‐19 infection
    • No articles were found on this topic.
  • Review 2: For patients with suspected or confirmed COVID‐19 infection to improve patient outcomes and to protect healthcare workers treating them
    • No completed studies on this topic, but identified 16 ongoing studies (including 14 randomized controlled trials (RCTs))
  • Review 3: For healthcare workers to protect them when treating patients with suspected or confirmed COVID‐19 infection
    • No completed studies on this topic, but identified 2 ongoing studies (including 2 RCTs)
|2020-09-21T07:45:25-04:00September 21st, 2020|COVID-19 Literature|Comments Off on Weekly Review: Clinical Studies – September 21, 2020

About the Author: Megan McHenry

Megan McHenry
Megan S. McHenry, MD, MS, FAAP is a pediatrician and an Assistant Professor of Pediatrics in the Ryan White Center for Pediatric Infectious Disease and Global Health at Indiana University School of Medicine. Dr. McHenry's research focuses on early childhood development in children living in resource-limited settings. This work is frequently aligned with community-engaged research and dissemination and implementation science frameworks. She primarily conducts research in collaboration with the Academic Model for Providing Access to Healthcare (AMPATH) Research Network in Kenya. Dr. McHenry currently has a career development award through the National Institutes of Health to develop a neurodevelopmental screening program for children born to HIV-infected mothers in Kenya. Dr. McHenry is also the Director of Pediatric Global Health Education and a co-Director of the Morris Green Physician-Scientist Development Program at Indiana University School of Medicine. In additional to global health lectures, she also educates residents and students on early childhood development, basic biostatistical techniques, research methodologies, and research ethics. She mentors multiple pediatric fellows, residents, and medical students interested in early childhood development within global contexts.

Get Involved with Indiana CTSI