Weekly Review: Clinical Studies – September 28, 2020

Weekly Review: Clinical Studies – September 28, 2020

Clinical Characteristics

Within a cohort study of 1641 adult patients with SARS-CoV-2, an elevated red blood cell distribution width (RDW) at admission and increasing RDW during hospitalization were associated with statistically higher increased in mortality risk.  

Within this meta-analysis that pooled data from 7503 individuals with SARS-CoV-2 and 2,962,160 controls , researchers found that  SARS-CoV-2 positive individuals are more likely to have blood group A (pooled OR 1.23, 95%CI: 1.09–1.40) and less likely to have blood group O (pooled OR = 0.77, 95%CI: 0.67–0.88).

In a retrospective data analysis from the University of Washington Medicine system, Non-English speakers were overall less likely to have had COVID-19 testing compared with English-speakers (4.7% [95% CI, 4.5%-4.9%] vs 5.6% [95% CI, 5.6%-5.7%]). Furthermore, the proportion of positive cases was 4.6-fold higher among non-English speakers  (18.6%; 95% CI, 16.8%-20.4%) compared with English speakers (4.0%; 95% CI, 3.8%-4.2%)

A living systematic review and meta-analysis on individuals who are asymptomatic and pre-symptomatic with SARS-CoV2 found that 20% (95%CI: 17-25%) remain asymptomatic during course of illness. The proportion of pre-symptomatic patients could not be determined due to heterogeneity.


Updated review on the SARS-CoV-2 vaccines in development. Phase I/II trial data is already available for several vaccine candidates and many have moved into Phase III trials. The data available so far suggests that an effective and safe vaccine might become identified within months rather than years (although scale-up and distribution will still need consideration).

Halloween advice:

CDC advice on holiday celebrations during COVID-19, including advice on Halloween and Dia de los Muertos

Fun map to simplify Halloween advice, by county

|2020-09-28T08:21:14-04:00September 28th, 2020|COVID-19 Literature|0 Comments

About the Author: Megan McHenry

Megan McHenry
Megan S. McHenry, MD, MS, FAAP is a pediatrician and an Assistant Professor of Pediatrics in the Ryan White Center for Pediatric Infectious Disease and Global Health at Indiana University School of Medicine. Dr. McHenry's research focuses on early childhood development in children living in resource-limited settings. This work is frequently aligned with community-engaged research and dissemination and implementation science frameworks. She primarily conducts research in collaboration with the Academic Model for Providing Access to Healthcare (AMPATH) Research Network in Kenya. Dr. McHenry currently has a career development award through the National Institutes of Health to develop a neurodevelopmental screening program for children born to HIV-infected mothers in Kenya. Dr. McHenry is also the Director of Pediatric Global Health Education and a co-Director of the Morris Green Physician-Scientist Development Program at Indiana University School of Medicine. In additional to global health lectures, she also educates residents and students on early childhood development, basic biostatistical techniques, research methodologies, and research ethics. She mentors multiple pediatric fellows, residents, and medical students interested in early childhood development within global contexts.

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