Servicecore – Do not remove
Service Cores
Denotes a CTSI Designated Core. Investigators who wish to apply for CTSI Core Pilot Grants must apply to a CTSI Core to be eligible to receive these special grants.
Learn More
3D Bioprinting Core at IUSM/IUPUI (3DBPC)
Director, 3D Bioprinter Core: Lester Smith, Ph.D.
3D Bioprinting is a form of automated tissue engineering which produces cell-based structures useful for a variety of in vitro and in vivo applications. Our Core has been created around a leading-edge technology, called ‘scaffold-free bioprinting’ (one which does not need biomaterials as cell scaffolds). The Core is equipped with the “Bio 3D Printer Regenova” the most advanced instrument of this type in the world, and the first installed in USA in an academic institution. In addition, our users have access to the automated microscopy platform IncuCyte ZOOM which, besides other specialized cellular assays, performs analysis and optimization of cellular spheroids, the building blocks needed for the operation of the Regenova robot. Our Core provides training, as well as qualified assistance for all steps of the bioprinting process. We also help the users identify the best solutions for their research needs. By connecting the users with other specialized cores, we help them with imaging of the constructs and with other forms of analysis. For those interested, we may facilitate access to ‘scaffold-dependent’ bioprinting as well. We work with the users to implement this new technology in grant proposals and assist them to prepare the data for publication. We also have regular Core meetings, structured as an informative journal club and/or topic-oriented discussions, both for the newly initiated and for the experienced users.
Learn More
Lester Smith
Email This Core
317-278-8057
Advanced Biomedical Information Technology Core
Director: Robert Henschel
Manager: Richard Meraz
Supercomputing, medical informatics, applications software, massive storage and advanced visualization services, collaboration tools, Indiana CTSI HUB.
Richard Meraz
Email This Core
+1-317-274-3338
Affiliation:
IU Simon Cancer Center, IU School of Medicine, Wells Center for Pediatric Research
Director: Karen Pollok, Ph.D.
The ABC conducts validated and highly reproducible in vitro and in vivo assays systems in endothelial and hematopoietic progenitor cell biology. For more information about the ABC, please visit our home page by clicking the link above.
The ABC is part of the Cell & Molecular Analysis Facility (CMAF) SuperCore.
Emily Sims
Email This Core
317-278-7232
Director: Karen Pollok, Ph.D.
The ABC conducts validated and highly reproducible in vitro and in vivo assays systems in endothelial and hematopoietic progenitor cell biology. For more information about the ABC, please visit our home page by clicking the link above.
The ABC is part of the Cell & Molecular Analysis Facility (CMAF) SuperCore.
Emily Sims
Email This Core
317-278-7232
Affiliation:
Purdue Discovery Park
Director: Ramaswamy Subramanian, Ph D.
Operations Manager: Natasha Nikolaidis
Biomolecular technologies, imaging and cytomics, bioinformatics support, and bionanotechnology with an emphasis on nanochemistry and functionalization of nanomaterials.
Director: Ramaswamy Subramanian, Ph D.
Operations Manager: Natasha Nikolaidis
Biomolecular technologies, imaging and cytomics, bioinformatics support, and bionanotechnology with an emphasis on nanochemistry and functionalization of nanomaterials.
Affiliation:
Center for Computational Biology and Bioinformatics, Department of Biochemistry & Molecular Biology, IU School of Medicine
Director: Yunlong Liu, Ph D.
Provides biomedical data management, informatic and analytical consulting, graphic and website design, and software and website hosting.
Dr. Yunlong Liu
Email This Core
317-278-9222
Director: Yunlong Liu, Ph D.
Provides biomedical data management, informatic and analytical consulting, graphic and website design, and software and website hosting.
Dr. Yunlong Liu
Email This Core
317-278-9222
Biological Evaluation Shared Resource Core
Director: Bennett D. Elzey, Ph.D.
In cancer biology, mouse models continue to play significant roles in studies of tumor invasion, metastasis and malignant transformation, as well as in studies examining responses to therapy. Key advancements have emerged in the development of animal models for cancer biology, including the advent of orthotopic models for metastasis, transgenic animals that have developmental pathways to tumorigenesis, and state-of-the-art immunocompromised strains. Transplanted human xenografts remain a primary tool for molecular discovery and evaluation. Despite their flaws and shortcomings, xenograft mouse models have played a significant role in cancer drug development in the past three decades, and mouse models will continue to be a foundation in the war against cancer.
At the Purdue University Center for Cancer Research (PCCR) where a vast pipeline of potential new agents for diagnosing and treating cancer are emerging, researchers need a productive and established facility for in vivo testing which can navigate the arena of murine cancer models. The mission of the Biological Evaluation Shared Resource (BE-SR) is to provide expert guidance to investigators in grant preparation, model selection and experimental design, and to perform toxicity testing and proof-of-concept efficacy studies to advance their projects using in vivo testing.
Bennett Elzey, Ph.D.
Email This Core
317-278-3449
Biophysical Analysis Laboratory (BAL)
Director: Jia Ma, PhD
The purpose of the BioAnalytical Lab at the Bindley Biosciences Center is to initiate long term productive collaborations and to provide a complete biophysical analysis of your sample. In the lab there are two analytical ultracentrifuges: Beckman-Coulter XLI and XLA, and a Biacore 3000 . With these instruments we can determine kinetic parameters, stoichiometry of binding, size distribution, shape, oligomerization state and other biophysical measurements. Complementing these traditional biophysical methods, the BioAnalytical Lab also provides mass spectrometric analyses at both the protein and peptide levels.
Natasha Nikolaidis
Email This Core
765.494.5997
Biostatistics Consulting Center
Core Director: Zhongxue Chen, Ph.D.
Associate Director: Stephanie Dickinson
The Biostatistics Consulting Center (BCC) is operated by the Department of Epidemiology and Biostatistics within the School of Public Health – Bloomington. The BCC is a research and service facility at Indiana University which provides a wide range of support and services through collaborative researches. We provide biostatistics and epidemiology consulting to IU faculty, research staff, graduate students, undergraduate students and non-university affiliated organizations or companies. Our mission is to provide our biostatistical and epidemiological expertise in support of health-related researches. Our team is comprised of Masters and PhD level statisticians and epidemiologists from the Department of Epidemiology and Biostatistics.
Stephanie Dickinson
Email This Core
812-856-9010
Affiliation:
IU School of Medicine
Director: Barry Katz, Ph D.
Collaborates with investigators in the planning, statistical design, data management, and analysis of health related clinical, laboratory and epidemiological research projects. There is no charge to IUSM investigators for biostatistics effort related to grant development.
(317) 274-2661
Director: Barry Katz, Ph D.
Collaborates with investigators in the planning, statistical design, data management, and analysis of health related clinical, laboratory and epidemiological research projects. There is no charge to IUSM investigators for biostatistics effort related to grant development.
(317) 274-2661
Affiliation:
Purdue Discovery Park
Director: Ali Shakouri, PhD
Nanofabrication cleanroom, bio-pharma clean room, nanometrology laboratories, nanomanufacturing laboratories, microelectronics and microfuidics fabrication and testing laboratories, 3D cell culture and tissue chip laboratories
Learn More
Ron Reger, Engineering Manager
Email This Core
765.494.6667
Director: Ali Shakouri, PhD
Nanofabrication cleanroom, bio-pharma clean room, nanometrology laboratories, nanomanufacturing laboratories, microelectronics and microfuidics fabrication and testing laboratories, 3D cell culture and tissue chip laboratories
Learn More
Ron Reger, Engineering Manager
Email This Core
765.494.6667
Bone and Body Composition Core
Director: Connie Weaver, Ph D.
Co-Deputy Director: Lilian Plotkin, PhD
Co-Deputy Director: Kathleen Hill Gallant, Ph D.
The Bone and Body Composition Core provides services and methods of determining bone density, bone geometry and body composition in humans and small animals. The core includes the GE/Lunar iDXA for clinical scans of total body, hip, spine and forearm for body composition and bone density. It also has a Stratek XCT 2000 (peripheral quantitative computed tomography or pQCT) for trabecular and cortical data primarily for forearms and lower legs. The core also provides histological services for basic science research. Both mineralized (plastic embedded) and soft tissue (paraffin embedded) specimens can be prepared. The core includes equipment for small animal bone imagery and evaluation such as a micro-computed tomography for 3D reconstructions of small bones and other solid materials. It has a DEXA (PIXImus) for small animal bone and body composition, as well as, an ECHO MRI for precise body composition measurements of fat, lean, free water, and total water masses in live ! animals. For histology, the core provides technical services and includes tissue processors, microtomes, and several microscopes with software for capturing histomorphometric measurements. The core can provide training and access to these machines.
Pamela Lachcik, LATG, MS
Email This Core
765-496-7464
Center for Comparative Translational Research
Director: Gert J. Breur, DVM, MS, PhD, DACVS
Translational research spans the continuum in which research findings from the researcher’s lab are moved to the patients ‘bedside’ (human) or ‘barn’ (animal). The Center for Comparative Translational Research (CTR) wants to make bridging the gap between benchtop and bedside/barn easier by helping researchers conduct comparative animal studies using induced and spontaneous disease models. It does so by facilitating, coordinating, integrating and stimulating comparative translational discovery, learning and engagement. The Center has Purdue and CTSI core facilities for animal pre-clinical and clinical studies, and for histology and image digitization. These laboratories aid researchers with their work on diseases, drugs, biologics and medical devices.
The mission of the CTR is to support interdisciplinary research by providing the professional expertise (histology, pathology, imaging, investigative surgery, etc.) and facilities needed to support preclinical and translational biomedical investigation. Examples of studies conducted with assistance of the Center are pre-clinical studies of orthopedic devices intended for animal and human use, clinical studies of treatment and prevention of respiratory diseases in horses and animal clinical trials evaluating the treatment of bladder cancer in Scottish Terriers, an animal model of human bladder cancer.
Gert Breur
Email This Core
765-496-3487
Center for Evaluation, Policy, and Research (CEPR)
Director: Patricia A. Muller, Ph.D
Centrally housed at IUB within the Office of the Vice Provost for Research, CEPR promotes and supports rigorous program evaluation and policy research. CEEP is interested in working with programs that promise real impact and improvement in education, the lives of children, and communities. Clients include federal and state agencies, public and private organizations, and foundations and endowments primarily working in the fields of STEM, public health, education, and youth development
Patricia A. Muller, Ph.D
Email This Core
812-855-4438
Center for Genomics and Bioinformatics
Director (interim): Scott Michaels
Lab Manager: Jun Liu
Lead Bioinformatician: Doug Rusch
The CGB was created in 2000 by the Office of the Vice Provost for Research (OVPR) and the College of Arts and Sciences at Indiana University. It receives additional support from the School of Informatics and Computing (SOIC), the School of Public Health, the School of Public and Environmental Affairs (SPEA), and IU Medical Sciences. The primary missions of the CGB are to: • Act as a service facility that provides IU faculty access to genome technologies and bioinformatic support. • Provide consulting and training that supports the development of genome-enabled research programs and grant proposals. • Develop new genome technologies and bioinformatics tools that are not easily purchased as a fee for service elsewhere. Our service offerings and policies are viewable at http://cgb.indiana.edu.
Rolf Rockliff
Email This Core
(812) 855-6877
Affiliation:
Indiana CTSI core, IU School of Medicine, Department of Biochemistry & Molecular Biology, Indiana Genomics Initiative (INGEN), Alcohol Research Center
Director: Yunlong Liu, PhD.
Associate Director: Xiaoling Xuei, PhD.
Provides genomic services including Next-generation sequencing, microarrays, targeted genotyping, allele-specific expression, methylation. Provides consultation for experimental design of genomics and genetics experiments, and related bioinformatics.
Yunlong Liu, PhD
Email This Core
Director: Yunlong Liu, PhD.
Associate Director: Xiaoling Xuei, PhD.
Provides genomic services including Next-generation sequencing, microarrays, targeted genotyping, allele-specific expression, methylation. Provides consultation for experimental design of genomics and genetics experiments, and related bioinformatics.
Yunlong Liu, PhD
Email This Core
Center for Nuclear Magnetic Resonance Spectroscopy
Director: Evgenii Kovrigin, Ph D.
Molecular structure and dynamics determination from a wide variety of compounds.
Evgenii Kovrigin, Ph D.
Email This Core
(574) 631-8359
Affiliation:
University of Notre Dame
Director: Jarek Nabrzyski, Ph.D.
The CRC houses two complementary resources: the High Performance Computing section, providing over 20,000 cores of computational power with the associated support infrastructure for both hardware and installed software, and the Cyberinfrastructure section, empowering Faculty and industry partners to develop research environments that support advanced data and information processing services including acquisition, storage, management, integration, mining and visualization of data.
Email This Core
(574) 631-2400
Director: Jarek Nabrzyski, Ph.D.
The CRC houses two complementary resources: the High Performance Computing section, providing over 20,000 cores of computational power with the associated support infrastructure for both hardware and installed software, and the Cyberinfrastructure section, empowering Faculty and industry partners to develop research environments that support advanced data and information processing services including acquisition, storage, management, integration, mining and visualization of data.
Email This Core
(574) 631-2400
Center for Survey Research (CSR)
Core Director: Ashley Clark
Director, Business Intelligence and Research Project Management Services: Reya Calistes
Director, Research Data Management Services: Jamie Roberts
Director, Research Technologies: Joe Wilkerson
Director, R&D and Research Laboratory: Lilian Yahng
Provides expert research design, sampling, questionnaire design, interface development and programming, data collection, data processing, and analysis services for wide range of qualitative and quantitative research projects.
Learn More
Center for Survey Research
Email This Core
(800) 258-7691
Affiliation:
University of Notre Dame
Director: David Hyde, Ph D.
3,000 sq. ft. facility consisting of 8 double-sided racks and 38 single-sided racks, maintained independently. Separate room houses the nursery.
David Hyde, Ph D.
Email This Core
(574) 631-8054
Director: David Hyde, Ph D.
3,000 sq. ft. facility consisting of 8 double-sided racks and 38 single-sided racks, maintained independently. Separate room houses the nursery.
David Hyde, Ph D.
Email This Core
(574) 631-8054
Chemical Genomics Core Facility
Director: Michael Weiss, MD, PhD
Director of Chemistry and Informatics: Lifan Zeng, Ph D.
Director of High Throughput Screening: Jingwei Meng, Ph D.
Chemical Genomics Core Facility is located within Van Nuys Medical Science Building, IUSM. Equipped with a collection of 227,680 diversity-oriented, drug-like, and natural small molecules in 9 non-redundant libraries, a variety of automated liquid handling and assay detection systems such as EnVision Multiplate reader and ArrayScan HCA System, modern equipment for medicinal and analytical chemistry including NMR, LC-QTOF MS, HPLC, Peptide Synthesizer, and sophisticated chemoinformatics tools.
Email This Core
Affiliation:
Purdue University Institute for Drug Discovery
Director: Zhong-Yin Zhang, PhD.
Associate Director: Lan Chen, PhD.
The Chemical Genomics Facility’s (CGF) mission is to provide expertise and resources to investigators from Purdue and other institutions to access state-of-the- art technologies and instrumentation in high-throughput screening (HTS) and high content screening (HCS), to facilitate the identification of chemical or genomic tools to study biological pathways and the discovery of lead agents for the development of novel therapeutics and diagnostic approaches. The facility is designed to be highly flexible in order to meet the needs of multiple users employing a range of assays from a wide range of disciplines. Our experienced facility staff work closely with each investigator and provide services through all stages of the lead discovery process.
Dr. Lan Chen
Email This Core
765-496-6668
Director: Zhong-Yin Zhang, PhD.
Associate Director: Lan Chen, PhD.
The Chemical Genomics Facility’s (CGF) mission is to provide expertise and resources to investigators from Purdue and other institutions to access state-of-the- art technologies and instrumentation in high-throughput screening (HTS) and high content screening (HCS), to facilitate the identification of chemical or genomic tools to study biological pathways and the discovery of lead agents for the development of novel therapeutics and diagnostic approaches. The facility is designed to be highly flexible in order to meet the needs of multiple users employing a range of assays from a wide range of disciplines. Our experienced facility staff work closely with each investigator and provide services through all stages of the lead discovery process.
Dr. Lan Chen
Email This Core
765-496-6668
CISAB Mechanisms of Behavior Laboratory
Director: David Sinkiewicz
The Center for the Integrative Study of Animal Behavior (CISAB) at IU Bloomington strives to promote interdisciplinary research and academic interactions between faculty members, researchers, and students at IU who study animal behavior from diverse perspectives, including biology, psychology, neuroscience, and biological anthropology. As a key part of that mission, the CISAB Mechanisms of Behavior Lab provides individualized training, consultation, services, equipment and bench space, with special focus on services valuable to CISAB-affiliated researchers. While some lab users primarily utilize specialized shared-use equipment and wet lab space that can be found in the CISAB Mechanisms of Behavior lab, others conduct a wide variety of billable procedures that the Lab supports, with costs billed on a per-sample or per-plate basis. Currently supported techniques include hormone extraction, enzyme immunoassay (EIA/ELISA), nucleic acid extraction (including automated), PCR, gel electrophoresis, and quantitative PCR preparation.
David Sinkiewicz
Email This Core
812-856-1139
Clinical Pharmacology Analytical Core
Director: Andi Masters
Provides services to 1) assist in the quantification of drugs and/or metabolites, 2) identification of metabolites, and 3) pharmacokinetic analysis of data.
Andi Masters
Email This Core
317-274-3053
Drosophila Genomic Research Center
Director: Peter Cherbas, Ph.D.
Resource for comparative genomics, including development of transgenic flies with mutations in candidate human genes.
Learn More
Affiliation:
IU School of Medicine
Director: Monte Willis, MD, PhD, MBA
Assistant Director: Caroline A. Miller
Provides electron microscopy services utilizing either scanning or transmission electron microscopy.
Learn More
Caroline A. Miller
Email This Core
(317) 274-8730
Director: Monte Willis, MD, PhD, MBA
Assistant Director: Caroline A. Miller
Provides electron microscopy services utilizing either scanning or transmission electron microscopy.
Learn More
Caroline A. Miller
Email This Core
(317) 274-8730
Flow Cytometry Resource Facility
Director: Edward Srour, Ph D.
The Flow Cytometry Facility provides essential and varied flow cytometric services to many IU Simon Cancer Center members at a reduced rate. The facility provides consultation, technical advice and collaboration, thus, promoting cutting-edge science and serving as a central common area for IU Simon Cancer Center investigators to interact and exchange scientific information.
The Flow Cytometry Facility is part of the Cell & Molecular Analysis Facility (CMAF) SuperCore.
Learn More
Edward Srour, Ph D.
Email This Core
(317) 274-3589
Affiliation:
University of Notre Dame
Director: Satish Adusumilli, DVM, MVSc, PhD
30,000 sq. ft. state-of-the-art animal research facility. Fully accredited with highly trained, certified, professional staff.
Satish Adusumilli
Email This Core
(574) 631-5393
Director: Satish Adusumilli, DVM, MVSc, PhD
30,000 sq. ft. state-of-the-art animal research facility. Fully accredited with highly trained, certified, professional staff.
Satish Adusumilli
Email This Core
(574) 631-5393
Genomics and Bioinformatics Core Facility
Director: Mike Pfrender, Ph.D
Director of Bioinformatics: Scott Emrich, Ph.D
Assistant Director: Melissa Stephens
The Genomics and Bioinformatics Core Facility (GBCF) provides high quality services using state-of-the-art technology to conduct genomics experiments and bioinformatics analysis. GBCF services encompass a broad range of applications, including genomics (metagenomics, cancer, microbial, targeted, non-model), transcriptomics, and epigenomics. The facilities offer comprehensive support for a diverse research community that spans basic biomedical research in human disease, pathogen genomics, population genomics, and environmental genomics. The 1500 square foot genomics facility houses specialized equipment including an Illumina MiSeq and Illumina NextSeq 500 sequencers, Applied Biosystems 3730xl 96-capillary sequencer, Agilent 2100 Bioanalyzer, Affymetrix GeneChip System, Qubit 2.0 Fluorometer, BioRad CRX384 RT PCR system, Covaris S220 high-intensity acoustic shearing equipment, and Sage Science BluePippin. Our computing facilities are equipped with high performance hardware and computational resources. The GBCF has expertise in sequence assembly, next-generation sequence analysis, and parallel computing with developed pipelines for downstream data analysis of next-generation short-read sequencing data. These pipelines include image processing, base calling, genome and transcriptome assembly, reference mapping, SNP calling, and analyzing population genomic data.
Mike Pfrender, Ph.D.
Email This Core
(574) 631-0591
Affiliation:
IUSM
Director: Naomi Swiezy, Ph.D., HSPP
The HANDS in Autism® Interdisciplinary Training and Resource Center was founded in 2004 as an extension of outreach and training offered at Riley Hospital for Children at IU Health and the IU School of Medicine. The vision of the HANDS in Autism® Center is to build local capacity through continuous learning and demonstrations of effective implementation of (1) evidence-based practices in supporting individuals with autism spectrum disorder and other neurodevelopmental and behavioral disorders across home, school, medical and other community settings and (2) regional community networks composed of same stakeholders bridging across systems and settings with a focus on shared responsibility for positive individual and family outcomes. Inherent in HANDS in Autism® practice and research is a focus on data-driven decision making, program evaluation and fidelity measurement in regards to effective implementation of identified best practices across settings.
Tiffany Neal, Ph.D.
Email This Core
274-2475
Director: Naomi Swiezy, Ph.D., HSPP
The HANDS in Autism® Interdisciplinary Training and Resource Center was founded in 2004 as an extension of outreach and training offered at Riley Hospital for Children at IU Health and the IU School of Medicine. The vision of the HANDS in Autism® Center is to build local capacity through continuous learning and demonstrations of effective implementation of (1) evidence-based practices in supporting individuals with autism spectrum disorder and other neurodevelopmental and behavioral disorders across home, school, medical and other community settings and (2) regional community networks composed of same stakeholders bridging across systems and settings with a focus on shared responsibility for positive individual and family outcomes. Inherent in HANDS in Autism® practice and research is a focus on data-driven decision making, program evaluation and fidelity measurement in regards to effective implementation of identified best practices across settings.
Tiffany Neal, Ph.D.
Email This Core
274-2475
Affiliation:
Purdue University – Center for Comparative Translational Research – College of Veterinary Medicine
Director: L. Tiffany Lyle, DVM, PhD, DACVP
The Histology Research Laboratory is a full service histology laboratory that provides general histology (including special stains), immunohistochemistry, frozen sectioning, decalcified and undecalcified bone histology, and slide digitization services. It also manages a large and small animal necropsy room. The laboratory may collaborate with investigators in the development of new techniques and in the characterization of animal models (e.g. phenotyping of genetically altered mice). Expertise in the processing of bone and implants is available.
Tiffany Lyle
Email This Core
(765) 494-9676
Director: L. Tiffany Lyle, DVM, PhD, DACVP
The Histology Research Laboratory is a full service histology laboratory that provides general histology (including special stains), immunohistochemistry, frozen sectioning, decalcified and undecalcified bone histology, and slide digitization services. It also manages a large and small animal necropsy room. The laboratory may collaborate with investigators in the development of new techniques and in the characterization of animal models (e.g. phenotyping of genetically altered mice). Expertise in the processing of bone and implants is available.
Tiffany Lyle
Email This Core
(765) 494-9676
Affiliation:
Indiana University
Director: Samir K Gupta
Cardiovascular disease (CVD) is the leading cause of death in the United States. As such, research is clearly needed to better understand the pathophysiology of CVD, reduce the incidence of CVD, and limit the consequences of CVD. However, epidemiologic and therapeutic studies that rely on the endpoint of actual CVD events are generally expensive and cumbersome; thus, such studies are usually prohibitive. Therefore, surrogate markers of CVD have increasingly been used in research. Physiologic and anatomic vascular imaging measures can provide both mechanistic and predictive information to help guide research and better inform the eventual studies on ‘hard endpoints’ that are needed to improve CVD health. The Human Vascular Imaging Core will provide the following services: (1) flow-mediated dilation (FMD) of the brachial artery – a measure of endothelium-dependent vascular reactivity; (2) nitroglycerin-mediated dilation (NTGMD) of the brachial artery – a measure of endothelium-independent vascular reactivity; and (3) carotid intima media thickness (CIMT) – a measure of cumulative arterial injury. By grouping these services within one Core, the interested IUPUI investigator can more directly access one or more of these services and work closely with the Core’s staff in choosing which services are most helpful for their particular research needs.
Samir K Gupta
Email This Core
317-274-7926
Director: Samir K Gupta
Cardiovascular disease (CVD) is the leading cause of death in the United States. As such, research is clearly needed to better understand the pathophysiology of CVD, reduce the incidence of CVD, and limit the consequences of CVD. However, epidemiologic and therapeutic studies that rely on the endpoint of actual CVD events are generally expensive and cumbersome; thus, such studies are usually prohibitive. Therefore, surrogate markers of CVD have increasingly been used in research. Physiologic and anatomic vascular imaging measures can provide both mechanistic and predictive information to help guide research and better inform the eventual studies on ‘hard endpoints’ that are needed to improve CVD health. The Human Vascular Imaging Core will provide the following services: (1) flow-mediated dilation (FMD) of the brachial artery – a measure of endothelium-dependent vascular reactivity; (2) nitroglycerin-mediated dilation (NTGMD) of the brachial artery – a measure of endothelium-independent vascular reactivity; and (3) carotid intima media thickness (CIMT) – a measure of cumulative arterial injury. By grouping these services within one Core, the interested IUPUI investigator can more directly access one or more of these services and work closely with the Core’s staff in choosing which services are most helpful for their particular research needs.
Samir K Gupta
Email This Core
317-274-7926
Affiliation:
Indiana Genomics Initiative (INGEN), IU School of Medicine
Director: Gary D. Hutchins, Ph D.
Imaging of tissue biochemistry, physiology, and anatomy provided by the Indiana Institute for Biomedical Imaging Sciences (IIBIS).
Mark Holland, PhD
Email This Core
(317) 274-4307
Director: Gary D. Hutchins, Ph D.
Imaging of tissue biochemistry, physiology, and anatomy provided by the Indiana Institute for Biomedical Imaging Sciences (IIBIS).
Mark Holland, PhD
Email This Core
(317) 274-4307
Imaging and Flow Cytometry Core Facility
Core Director: Charles Tessier
The Imaging and Flow Cytometry Core Facility is located at the Indiana University School of Medicine South Bend campus.
Charles Tessier
Email This Core
574-631-2519
Affiliation:
IU Simon Cancer Center
Director: Karen E. Pollok, Ph D.
Manager: Tony Sinn
The IUSCC In Vivo Therapeutics Core (IVT) provides investigators with cost-effective and comprehensive services to facilitate the development and testing of novel pharmacological & cellular therapies. The Core will act as a liaison between the Principal Investigator and any other outcome analyses from live-phase studies. The IVT Core maintains multiple on-site breeding colonies, including: NOD/scid, NOD/scid/IL2Rgnull, Boy/J, F1/BoyJxC57Bl/6 mice, C57BL/6-Tg(UBC-GFP)30Scha/J, and Mgmt -/-
Tony Sinn
Email This Core
317-274-8811
Director: Karen E. Pollok, Ph D.
Manager: Tony Sinn
The IUSCC In Vivo Therapeutics Core (IVT) provides investigators with cost-effective and comprehensive services to facilitate the development and testing of novel pharmacological & cellular therapies. The Core will act as a liaison between the Principal Investigator and any other outcome analyses from live-phase studies. The IVT Core maintains multiple on-site breeding colonies, including: NOD/scid, NOD/scid/IL2Rgnull, Boy/J, F1/BoyJxC57Bl/6 mice, C57BL/6-Tg(UBC-GFP)30Scha/J, and Mgmt -/-
Tony Sinn
Email This Core
317-274-8811
Indiana Center for Biological Microscopy (ICBM)
Scientific Director: Kenneth Dunn, Ph D.
High resolution confocal epifluorescence and multiphoton microscopy of cells, tissues and organs in living animals and fixed samples, and development of methods for imaging and digital image analysis.
Malgorzata Kamocka
Email This Core
Indiana CTSI Biospecimen Management Core (CTSL/SSF)
CTSL Director: Christie M. Orschell, Ph.D.
SSF Director: Robert Orr
The Biospecimen Management Core (BMC), comprised of the Specimen Storage Facility and the Clinical and Translational Support Laboratory, offers cost-efficient processing & storage services with a focus on consistent quality and sample integrity.
The Specimen Storage Facility (SSF) currently maintains four mechanical freezer storage sites, a LN2 freezer storage site, and a nucleic acid extraction laboratory. Both investigator and SSF owned freezers are monitored and maintained by SSF staff 24/7 to virtually eliminate specimen loss due to freezer failures. Quality is maintained via our contracted independent QA oversight and guidance. Our facility and procedures are ISBER compliant (International Society for Biological and Environmental Repositories).
The Clinical and Translational Support Laboratory (CTSL) provides SOP-driven, protocol specific processing and shipping services for studies collecting human derived research specimens. The highest levels of quality and consistency are assured due to our voluntary compliance to GCPs and GLPs along with independent QA oversight.
Robert Orr
Email This Core
317-944-9726
Indiana University Bloomington Electron Microscopy Center
Faculty Director: Dr. Roger Innes
Staff Director: Dr. David Morgan
The Electron Microscopy Center (EMC) provides the IU Bloomington with a state of the art facility for electron microscopy and elemental analysis of materials. The primary focus of the center is to facilitate data acquisition and analysis by campus research personnel. The EMC provides well-maintained equipment, data acquisition services, hands-on training, and fee-for-service by highly trained electron microscopists on staff. Comprising the center is a physical lab space housing a JEOL 3200 intermediate voltage electron microscope and an adjacent space for image processing, both in Simon Hall, together with the JEOL 1010 TEM with associated specimen preparation space in Myers Hall. The center currently has three technical personnel dedicated to materials science and life science.
Dr. David Morgan
Email This Core
812.856.1457
Indiana University Imaging Research Facility (IRF)
MRI physicist: Hu Cheng, Ph D.
Director: Dan Kennedy, PhD.
The Imaging Research Facility houses a 3 Tesla Siemens TIM Trio MRI scanner with high-fidelity infra-red eye tracking in addition to a high-density (256 channel) EEG/TMS laboratory. The IRF has an additional EEG system that is MRI- and TMS-compatible.
Dan Kennedy, PhD.
Email This Core
812-856-3723
Infectious Diseases Laboratory
Director: Aaron Ermel, MD
The Infectious Diseases Laboratory (IDL) has provided research support services for multiple investigators as well as clinical diagnostic services for multiple healthcare facilities since 1983. The IDL provides diagnostic services for multiple sexually transmitted pathogens and supports researchers investigating these pathogens as well as behavioral scientists who use acquisition of sexually transmitted pathogens as biologic correlates of sexual behavior. In addition, the IDL has developed its own research agenda participating in research trials of new technologies for the diagnosis of sexually transmitted pathogens, some of which have become standard diagnostic techniques. In addition to the main laboratory, there is an adjacent laboratory under the direction of Dr. Darron Brown that also provides diagnostic services.
Jim Williams, Lab Manager
Email This Core
317-274-3248
Investigational Agent Acquisition Program
Goal: The goal of the CTSI Investigational Agent Acquisition Program (IAAP) is to assist CTSI investigators seeking investigational agents for use in clinical trials. Scope: The IAAP program will assist in acquiring drugs, neutraceuticals, biologics or other materials to be used in a Investigational New Drug Application or IND-exempt clinical trial. Eligibility: Any faculty within the CTSI member institutions. Overview: Moving bench research into the clinic has a variety of hurdles. One challenge repeatedly identified by investigators is the acquisition of novel products of interest that are suitable for use in clinical trials. For the most part, investigators have little or no experience in the regulatory requirements for an investigational agent; nor do they have expertise in identifying suitable vendors who can manufacture the required material. The manufacture of some materials, such as neutraceuticals, are generally straightforward and the IAAP can utilize its expertise to generate a roadmap and identify vendors for an investigator to consider. In other cases, for example when suitable active pharmaceutical ingredient (API) is not available, the manufacturing process is highly specialized, the properties of the material are not well characterized, or significant work will be required in defining a manufacturing plan and identifying a suitable production facility, consultants with specific experience must be engaged. The IAPP will meet with investigators, assess their needs and either facilitate the acquisition process or facilitate the hiring of outside consultants skilled in product acquisition. While advice will be provided, ultimately any decisions regarding the manufacturing plan and the acceptability of the material generated lies with the principle investigator. Therefore, users of the IAPP are expected to drive the process, providing requested information in a timely manner and maintain active interactions with consultants and manufacturers.
Learn More
Padma Portonovo
Email This Core
Affiliation:
IUSM
Director: Dr. Carmella Evans-Molina
Associate Director: Dr. Sarah Tersey
The Islet and Physiology Core of the Indiana Diabetes Research Center provides IUSM and regional (IUB, IUPUI, and Purdue University) investigators with the capability to obtain high quality rodent pancreatic islets for study. The Core also provides services for islet transplantation and will assist investigators who wish to perform immunohistochemistry, immunofluorescence, and/or analysis of beta cell mass on whole pancreata from mouse and rat models. We are also pleased to offer several services for rodent metabolic characterization, including performance of insulin and glucose tolerance testing, analysis of body composition and metabolic cage analysis using TSE System cages. The Islet and Physiology Core functions as part of the Indiana Diabetes Research Center and the IUSM Center for Diabetes and Metabolic Diseases, to foster new knowledge, support training, and promote basic and translational research in diabetes and related metabolic disorders and their complications.
Sarah Tersey
Email This Core
(317)278-8940
Director: Dr. Carmella Evans-Molina
Associate Director: Dr. Sarah Tersey
The Islet and Physiology Core of the Indiana Diabetes Research Center provides IUSM and regional (IUB, IUPUI, and Purdue University) investigators with the capability to obtain high quality rodent pancreatic islets for study. The Core also provides services for islet transplantation and will assist investigators who wish to perform immunohistochemistry, immunofluorescence, and/or analysis of beta cell mass on whole pancreata from mouse and rat models. We are also pleased to offer several services for rodent metabolic characterization, including performance of insulin and glucose tolerance testing, analysis of body composition and metabolic cage analysis using TSE System cages. The Islet and Physiology Core functions as part of the Indiana Diabetes Research Center and the IUSM Center for Diabetes and Metabolic Diseases, to foster new knowledge, support training, and promote basic and translational research in diabetes and related metabolic disorders and their complications.
Sarah Tersey
Email This Core
(317)278-8940
IU Bloomington Flow Cytometry Core Facility
Manager: Christiane Hassel, MS
Director: Dr. John Foley
Associate Director: Dr. Kris Klueg
The IU Bloomington Flow Cytometry Core Facility (FCCF) offers flow cytometry analysis and cell sorting services. It houses the FACS Aria II, a state-of-the-art sorter/analyzer capable of analyzing fourteen colors and seventeen parameters, the COPAS Select, a Drosophila embryo and large particle sorter, the LSRII, a thirteen-color analyzer with HTS option, the FACSCalibur, a four-color analyzer, as well as Z2 Coulter counter technology used for determining cell concentration and size distribution. Services include technician assisted sorting, as well as training for analyzers and Coulter instruments. Help with experimental design is also available. NEWLY ADDED SUMMER 2017! – Miltenyi MACSQuant VYB mobile flow cytometer – 3 laser, 8 parameter instrument on a cart. Multi-well and absolute counting capabilities.
Learn More
Christiane Hassel
Email This Core
812-855-7101
IUB – Light Microscopy Imaging Center (LMIC)
Executive Director: Sidney Shaw
Facility Manager: Jim Powers
To provide user-friendly access to state of the art light microscopy for the IU research community. To promote the development of researchers that are knowledgeable, confident and comfortable in the use of microscopes.
IUB Mass Spectrometry Facility
Director: Jonathan Karty, PhD
Description: Since 1965, the Mass Spectrometry Facility (MSF) has existed to provide top-quality mass spectrometry support to the faculty research groups of the Indiana University-Bloomington Chemistry Department. The MSF is one of many technical support facilities in the Chemistry Department; its faculty advisor is Dr. Jim Reilly. The laboratory is located in rooms A411 between Electronics Instrument Services and the Indiana Molecular Structure Center and A454 in the Chemistry Building.
Jonathan Karty, PhD
Email This Core
IUSCC Tissue Procurement and Distribution Core
Director: Kathy Miller, MD
Technical Advisor: George Sandusky
Technical Advisor: Oscar Cummings
Operations Manager: Mary Cox
The broad scientific objective of Indiana University Simon Cancer Center (IUSCC) is to conduct high quality, cutting-edge basic and clinical research for the improved understanding and advancement in the treatment of human malignancies. The ability to successfully investigate the biological basis of cancers, translate basic research to the clinical setting, and better understand the relevance of observed clinical or population-based phenomena through laboratory-based research is greatly facilitated by the availability of an extensive repository of tissue samples, with accompanying pathologic and clinical data, procured from patients with malignancies and normal controls. To serve the needs of the cancer center in achieving this end, the IUSCC Solid Tissue Bank began providing solid tumors in 1996. In 2008, the Hematologic Malignancies Tissue Bank was established to provide hematological malignancies. Since that time, the IUSCC Solid Tissue Bank has continued to provide tissue for the discovery of new drug targets and biomarkers, the development of cancer cell lines and for DNA and RNA research. Over the past 10 years, IUSCC has provided hundreds of tumor samples to many IU leading scientists and affiliates. Specimens with confirmed histology and diagnosis are available from surgery within 90 minutes post excision from a large variety of cancers. Normal adjacent tissue, metastatic tissue, and archival blocks are available. The Hematologic Malignancies Tissue Bank serves as a tissue procurement resource for the centralized banking of blood, bone marrow, leukapheresis, and buccal swab specimens procured from patients with hematologic malignancies and normal controls. All malignant samples are accompanied by clinical and pathological data. Beyond simply serving as a repository of tissue, the IUSCC Tissue Bank is a shared resource of samples that is made available to researchers for the examination of relevant cellular and molecular properties and used in preclinical drug development assays. Please contact us at our email account IN-CANC-TissueBank@exchange.iu.edu with any questions.
Mary Cox
Email This Core
317-274-4320
Keck Center for Transgene Research (resources)
Director: Francis J. Castellino, Ph D.
Unique research resources available for collaboration
Victoria A. Ploplis, Ph.D.
Email This Core
(574) 631-8996
Laboratory for Biological Mass Spectrometry
Director: Jonathan Trinidad
Previous success in proteomics research that has been initially funded by sources such as INGEN, the 21st Century Fund, and the NIH has enabled the emergence of the Proteomics Facility in Simon Hall. This facility has sufficient expertise and instrumentation to serve as an extraordinary asset for life sciences researchers at IUB and beyond.
Jonathan Trinidad
Email This Core
812-856-4126
Life Science Microscopy Facility
Director: Chris Gilpin
The LSMF is a full service electron microscopy core with both service and individual use options. Equipment includes field-emission SEMs equipped with cryo, EDX, low vacuum, and tensile stage. Also available are TEMs, routine and cryo sample preparation instrumentation, and other support equipment. Basic light microscopy also available (Bright-field, Nomarski DIC contrast, Fluorescence, stereo).
Chris Gilpin
Email This Core
765-494-6666
Affiliation:
Indiana University Bloomington
Executive Director: Charles E. Dann, Ph.D.
The Macromolecular Crystallography Facility Integrated with the Crystallization Automation Facility (MCF/CAF) provides all equipment necessary to facilitate research in all aspects of Structural Biology at IU Bloomington. New instrumentation allows high throughput macromolecular crystallography using advanced robotics. The Phoenix DT and Gryphon LCP drop setter robots commercialized by Art Robbins Instruments can set up crystallization trails with high accuracy and minimizing the total amount of purified sample used during the screening. The Minstrel HT-UV (Rigaku) is a fully automated high-throughput ultraviolet and visible crystal imaging and protein crystal monitoring system, which is coupled to two Gallery™ HT incubator storage systems. Using the CrystalTrak software in situ or online the users can control, optimize, visualize and document automatically all the crystallization screening process. In addition, the Alchemist DT (Rigaku), also connected to CrystalTrak software, allows automatic liquid handling for protein crystallization optimization. Stereoscopes coupled to high definition cameras and supplies for crystal manipulation are also provided by the facility. Moreover, computational resources facilitate structure determination and refinement with the latest programs available. In addition, IUB is a member institution in the Molecular Biology Consortium, which allows for easy and very frequent remote synchrotron access on beamline 4.2.2 at the Advanced Light Source (ALS), at Berkeley, California. Therefore, testing for crystal/diffraction quality and/or data collection is done effortless and time-effectively. MCF/CAF was founded to facilitate and encourage research endeavors in structural biology and to provide centralized resources for training and education in latest crystallographic and structural biology techniques.
Giovanni Gonzalez-Gutierrez
Email This Core
812-856-7505
Executive Director: Charles E. Dann, Ph.D.
The Macromolecular Crystallography Facility Integrated with the Crystallization Automation Facility (MCF/CAF) provides all equipment necessary to facilitate research in all aspects of Structural Biology at IU Bloomington. New instrumentation allows high throughput macromolecular crystallography using advanced robotics. The Phoenix DT and Gryphon LCP drop setter robots commercialized by Art Robbins Instruments can set up crystallization trails with high accuracy and minimizing the total amount of purified sample used during the screening. The Minstrel HT-UV (Rigaku) is a fully automated high-throughput ultraviolet and visible crystal imaging and protein crystal monitoring system, which is coupled to two Gallery™ HT incubator storage systems. Using the CrystalTrak software in situ or online the users can control, optimize, visualize and document automatically all the crystallization screening process. In addition, the Alchemist DT (Rigaku), also connected to CrystalTrak software, allows automatic liquid handling for protein crystallization optimization. Stereoscopes coupled to high definition cameras and supplies for crystal manipulation are also provided by the facility. Moreover, computational resources facilitate structure determination and refinement with the latest programs available. In addition, IUB is a member institution in the Molecular Biology Consortium, which allows for easy and very frequent remote synchrotron access on beamline 4.2.2 at the Advanced Light Source (ALS), at Berkeley, California. Therefore, testing for crystal/diffraction quality and/or data collection is done effortless and time-effectively. MCF/CAF was founded to facilitate and encourage research endeavors in structural biology and to provide centralized resources for training and education in latest crystallographic and structural biology techniques.
Giovanni Gonzalez-Gutierrez
Email This Core
812-856-7505
Mass Spectrometry and Proteomics Facility
Director: William Boggess, Ph D.
Analysis of large and small molecules using several ionization methods, low or high resolution, hyphenated techniques, proteomics, and metabolomics.
Bill Boggess
Email This Core
(574) 631-4027
METACyt Biochemical Analysis Center
Director: Jonathan A. Karty, Ph D.
Jonathan A. Karty, Ph D.
Email This Core
812-856-5620
Affiliation:
University of Notre Dame
Director: Allen Oliver, Ph D.
The Molecular Structure Facility at the University of Notre Dame provides for X-Ray structural studies of small (ca. 2kDa) molecules. The Facility has the capability to examine a wide range of molecules from “light atom” biologically relevant to metal-complexed compounds which can be readily analyzed using non-destructive techniques.
Allen Oliver, Ph D.
Email This Core
(574) 631-5935
Director: Allen Oliver, Ph D.
The Molecular Structure Facility at the University of Notre Dame provides for X-Ray structural studies of small (ca. 2kDa) molecules. The Facility has the capability to examine a wide range of molecules from “light atom” biologically relevant to metal-complexed compounds which can be readily analyzed using non-destructive techniques.
Allen Oliver, Ph D.
Email This Core
(574) 631-5935
Affiliation:
IUSM
Director: Christie M. Orschell, Ph. D
The Multiplex Analysis Core (MAC) offers microplate-based bioassay systems that can perform multiplex analysis of multiple different analytes in a single sample. Multiplex systems are faster, more efficient, and use less sample volume than other technologies such as ELISA and Western Blot. Off-the-shelf kits are available to detect analytes such as chemokines, cytokines, hormones, cell signaling molecules, phosphoproteins, or nucleic acids in areas such as inflammation, metabolism, cardiovascular disease, oncology, immunology, etc. Custom kits designed by the investigator are also a possibility.
The MAC uses a Bio-Plex 200 bead-based suspension system (Luminex platform) for analyte quantitation in the picogram level. Immunoassay kits are available for human, mouse, bovine, canine, porcine, rat, and primate.
The MAC is located at R3-C335 (Walther Hall), 980 W. Walnut St., Indianapolis, IN.
Artur Plett, Ph.D.
Email This Core
(317)274-2485
Director: Christie M. Orschell, Ph. D
The Multiplex Analysis Core (MAC) offers microplate-based bioassay systems that can perform multiplex analysis of multiple different analytes in a single sample. Multiplex systems are faster, more efficient, and use less sample volume than other technologies such as ELISA and Western Blot. Off-the-shelf kits are available to detect analytes such as chemokines, cytokines, hormones, cell signaling molecules, phosphoproteins, or nucleic acids in areas such as inflammation, metabolism, cardiovascular disease, oncology, immunology, etc. Custom kits designed by the investigator are also a possibility.
The MAC uses a Bio-Plex 200 bead-based suspension system (Luminex platform) for analyte quantitation in the picogram level. Immunoassay kits are available for human, mouse, bovine, canine, porcine, rat, and primate.
The MAC is located at R3-C335 (Walther Hall), 980 W. Walnut St., Indianapolis, IN.
Artur Plett, Ph.D.
Email This Core
(317)274-2485
Notre Dame Histology Core Facility
Core Director: Bradley Smith, Ph.D.
The Notre Dame Histology Facility (NDHF) provides a means to examine biological processes by use of immunohistochemical techniques and pathology. The facility is equipped with a Leica TP 1020 Tissue Processor, Leica microtome, Tissue-Tek III embedding station, and a Leica Cryostat with a special Tungsten blade attachment capable of slicing un-decalcified bone. The objective of the histology core is to provide high quality stained tissue sections on microscope slides. Services include tissue fixation, processing, embedding, sectioning, and staining of paraffin or frozen tissue sections. Staining of tissue sections ranges from routine H&E’s (Hematoxylin-Eosin) to special stains demonstrating specific tissue structures. The Core offers immunohistochemical staining with antibodies supplied by investigators. Lab Manager: Sarah Chapman, MBA, HT (574) 631-3813 http://ndiif.nd.edu/histology/
Sarah Chapman
Email This Core
574-631-3813
Notre Dame Integrated Imaging Facility
Director: Bradley D. Smith, Ph D.
Houses and integrates three areas of imaging expertise. Makes available an integrated suite of sophisticated microscopes and imaging stations that enable the expert users to attack the most complex modern research problems and, equally important, the resident professional staff (technicians and research specialists) to guide the non-expert users and allow them to conduct experiments that were previously beyond their limits.
Affiliation:
Indiana University School of Medicine, Purdue University
Director: Michael Sturek, Ph.D.
Director: Mouhamad Alloosh, M.D.
The overall goal of the core is to provide Ossabaw miniature swine, technical resources, and tissues for preclinical translational research. Please see also our website for additional description, research articles, etc. We have the only research and large-scale breeding colony of Ossabaw swine in the world that is certified to have a gene mutation, the metabolic syndrome, and heart disease. The striking similarities between swine and human biochemistry, physiology, and pathophysiology provide outstanding opportunities for research in translational medicine. Publications and ongoing projects currently have found 32 uses for Ossabaw miniature swine. Providing this infrastructure and technical and intellectual resource will significantly reduce a limitation for swine research overall.
Mouhamad Alloosh, M.D.
Email This Core
317-274-7948
Director: Michael Sturek, Ph.D.
Director: Mouhamad Alloosh, M.D.
The overall goal of the core is to provide Ossabaw miniature swine, technical resources, and tissues for preclinical translational research. Please see also our website for additional description, research articles, etc. We have the only research and large-scale breeding colony of Ossabaw swine in the world that is certified to have a gene mutation, the metabolic syndrome, and heart disease. The striking similarities between swine and human biochemistry, physiology, and pathophysiology provide outstanding opportunities for research in translational medicine. Publications and ongoing projects currently have found 32 uses for Ossabaw miniature swine. Providing this infrastructure and technical and intellectual resource will significantly reduce a limitation for swine research overall.
Mouhamad Alloosh, M.D.
Email This Core
317-274-7948
Oxidative Stress and Environmental Analysis Core
Director: Lisa Kamendulis
The Oxidative Stress Environmental Analysis Core laboratory has established a number of measurements for assessing oxidative stress and damage in a variety of biological samples with excellent accuracy and reproducibly using state of the art LC-MSMS, GC, and PCR equipment.
Lisa Kamendulis
Email This Core
812-855-3188
Pharmaceutical Manufacturing Core Facility
Director: Daniel T. Smith, Ph D.
Pharmaceutical Manufacturing Core Facility provides support and capabilities for a wide range of research in pharmaceutical development and manufacturing. Technical support for the Facility is provided by the faculty of Industrial and Physical Pharmacy who have extensive pharmaceutical manufacturing experience in both industrial and academic environments.
765-463-1989 x116
Physical and Biophysical Instrumentation Facility
Director: Adam Zlotnick, PhD
Core Manager: Giovanni Gonzalez-Gutierrez, PhD
This state-of-the-art facility has been established to facilitate and encourage biomolecular research endeavors and to provide a centralized resource for training and education. The facility is under the management of Giovanni Gonzalez-Gutierrez. In this role, Dr. Gonzalez-Gutierrez can handle all your biophysical characterization needs from training to data interpretation. If you have any questions or need more information, please feel free to contact Dr. Gonzalez-Gutierrez.
Giovanni Gonzalez-Gutierrez
Email This Core
812-856-7505
Pre-Clinical Research Laboratory
Director: Gert Breur, DVM, MS, PhD, DACVS
Manager: Robyn McCain, BS, RLATg
The Pre-Clinical Research Laboratory (PCL) facilitates pre-clinical animal research by providing research expertise, technical support, facilities and equipment. The PCL is a multidisciplinary laboratory where faculty conduct advanced pre-clinical research using induced animal models ranging from rodents to pigs and sheep. Board certified veterinary surgeons associated with the laboratory are available for consultation and collaboration and technical assistance is provided by highly trained veterinary technicians.
Robyn McCain
Email This Core
765-496-2504
Affiliation:
Indiana Genomics Initiative (INGEN), IU School of Medicine
Director: Amber Mosley, Ph.D.
Identification, quantitation and characterization of proteins, instrumentation development.
Dr. Amber Mosley
Email This Core
(317) 278-2350
Director: Amber Mosley, Ph.D.
Identification, quantitation and characterization of proteins, instrumentation development.
Dr. Amber Mosley
Email This Core
(317) 278-2350
Affiliation:
Purdue University Discovery Park
Director: Jyothi Thimmapuram
The vision of the Bioinformatics Core is to facilitate, amplify, and accelerate biological research and discovery through application of bioinformatics. It will do so by delivering high quality analysis in a timely and economical manner. It will be responsive to customer needs and evolve with advances in the field. It will actively engage in and seek out opportunities to advance the educational mission of the University.
Jyothi Thimmapuram
Email This Core
765.496.6252
Director: Jyothi Thimmapuram
The vision of the Bioinformatics Core is to facilitate, amplify, and accelerate biological research and discovery through application of bioinformatics. It will do so by delivering high quality analysis in a timely and economical manner. It will be responsive to customer needs and evolve with advances in the field. It will actively engage in and seek out opportunities to advance the educational mission of the University.
Jyothi Thimmapuram
Email This Core
765.496.6252
Purdue Bioscience Imaging Facility
Director: Andy Schaber
The Bindley Imaging Facility (BIF) enables imaging of all types of biologic and non-biologic samples. Our systems can image samples ranging in size from rodents to nanometer sized objects. We train users how to use the imaging instruments and support users in sample preparation, anesthesia, image acquisition and analysis. Our systems can be divided in Microscope and Pre-clinical Imaging. We have multiple microscope systems; including confocals, multi-photo systems on both inverted and upright platforms, a super resolution (SIM and STORM) with TIRF and a live-cell instrument. Our Pre-clinical systems include bioluminescent and fluorescent imagers, a mCT with resolution capability down to 4.5um voxels as well as nuclear medicine instrument (SPECT/PET/CT).
Andy Schaber
Email This Core
765-496-3148
Affiliation:
Purdue University
Core Director: Dr. Wen Jiang
The Purdue Cryo-EM Facility is a member of the Purdue EM Consortium and a designated Indiana CTSI Core Facility. Our facility is available to Purdue, other academic institutes, and industry users. It provides state-of-the-art instruments and expertise for high resolution structure determination of viruses, larger macromolecular complexes, nano-particles, as well as tomographic visualization of virus-cell interactions by cryo-electron microscopy (cryo-EM) and three-dimensional (3-D) image reconstruction.
Wen Jiang, Ph.D.
Email This Core
(765) 496-8436
Core Director: Dr. Wen Jiang
The Purdue Cryo-EM Facility is a member of the Purdue EM Consortium and a designated Indiana CTSI Core Facility. Our facility is available to Purdue, other academic institutes, and industry users. It provides state-of-the-art instruments and expertise for high resolution structure determination of viruses, larger macromolecular complexes, nano-particles, as well as tomographic visualization of virus-cell interactions by cryo-electron microscopy (cryo-EM) and three-dimensional (3-D) image reconstruction.
Wen Jiang, Ph.D.
Email This Core
(765) 496-8436
Purdue Flow Cytometry and Cell Sorting Facility
Manager: Dr. Jill Hutchcroft
The Flow Cytometry and Cell Separation Facility (FCCSF) provides both state-of-the-art equipment and highly experienced personnel to enable the rapid identification, quantification, and separation of eukaryotic and prokaryotic cells. Flow and image cytometry services are used in the research of life sciences investigators based in a variety of Colleges and Departments.
Learn More
Dr. Jill Hutchcroft
Email This Core
765-586-1130
Affiliation:
Purdue University
Director: Phillip SanMiguel, Ph.D.
The Purdue Genomics Core accepts DNA or total RNA for construction of DNAseq and several types of RNAseq libraries to be run on an Illumina HiSeq 2500 or Illumina MiSeqs. In addition we offer a novel service, WideSeq, that allows full sequence of double stranded DNA samples up to 100-200kb for $20.
Phillip San Miguel
Email This Core
765-496-6328
Director: Phillip SanMiguel, Ph.D.
The Purdue Genomics Core accepts DNA or total RNA for construction of DNAseq and several types of RNAseq libraries to be run on an Illumina HiSeq 2500 or Illumina MiSeqs. In addition we offer a novel service, WideSeq, that allows full sequence of double stranded DNA samples up to 100-200kb for $20.
Phillip San Miguel
Email This Core
765-496-6328
Purdue Metabolite Profiling Facility
Director: Bruce Cooper
The Metabolite Profiling Facility (MPF) provides state-of-the-art technologies that enable both qualitative Metabolite (efforts to define or catalog all components of a metabolome) and quantitative Metabolite (understanding differential concentrations of metabolites) for metabolite profiling in biological systems. This facility employs highly sensitive mass spectrometry coupled with multi-dimensional gas and liquid chromatography (GC and LC-MS) to provide researchers with new technologies and methods development, as well as expert training and consultation. This research capability allows assessment of the hierarchical flow of information from the genome to the transcriptome, proteome, and metabolome ultimately defines cellular phenotypes.
Bruce Cooper
Email This Core
(765) 494-6282
Affiliation:
Purdue University
Facilities Director: Dr. Gregory Tamer, Jr.
Faculty Director of Life Sciences MRI Facility: Dr. Ulrike Dydak
Faculty Director of Small Animal MRI Facility: Dr. Zhongming Liu
Faculty Director of Engineering MRI Facility: Dr. Tom Talavage
The Purdue MRI Facility now is the union of three MR scanners (and facilities) located directly on the campus of Purdue University. The Small Animal MRI Facility, located in the Bindley Bioscience Center, houses a Bruker Biospec 7T MRI system. The Life Sciences MRI Facility houses a 3T Siemens MAGNETOM Prisma MRI system, and the Engineering MRI Facility houses a GE Discovery MR750 3T MRI system. The latter two share a building and several resources. All three systems are available for research involving magnetic resonance imaging (MRI), MR spectroscopy (MRS), and other MR applications.
Dr. Gregory Tamer, Jr.
Email This Core
765-588-7134
Facilities Director: Dr. Gregory Tamer, Jr.
Faculty Director of Life Sciences MRI Facility: Dr. Ulrike Dydak
Faculty Director of Small Animal MRI Facility: Dr. Zhongming Liu
Faculty Director of Engineering MRI Facility: Dr. Tom Talavage
The Purdue MRI Facility now is the union of three MR scanners (and facilities) located directly on the campus of Purdue University. The Small Animal MRI Facility, located in the Bindley Bioscience Center, houses a Bruker Biospec 7T MRI system. The Life Sciences MRI Facility houses a 3T Siemens MAGNETOM Prisma MRI system, and the Engineering MRI Facility houses a GE Discovery MR750 3T MRI system. The latter two share a building and several resources. All three systems are available for research involving magnetic resonance imaging (MRI), MR spectroscopy (MRS), and other MR applications.
Dr. Gregory Tamer, Jr.
Email This Core
765-588-7134
Affiliation:
Purdue University – Bindley Bioscience Center
Director: Uma Aryal, Ph.D.
Innovative methodologies and technologies are developed in the Purdue Proteomics Facility (PPF), a shared facility of the Bindley Bioscience Center (BBC) and the Purdue Cancer Center. This facility enables never-before-possible analysis of post-translational modifications of the proteome. Coupled with new proteomics infrastructure and expert scientific researchers, these facilities provide unique approaches to intact protein (‘top-down’) and peptide fragment (‘bottom-up’) analyses. Many projects in Bindley Bioscience Center employ these technologies for biomarker discovery in health and disease – a signature research area at the BBC. Capabilities – Amino acid analysis of peptides or proteins, automated and manual computer search and analyses, bioinformatic consultation, equipment and software for complete 2D gel analyses, ESI analysis of intact proteins, high throughput comparative proteomics with LCMS-MS/MS, identification and characterization of peptide and protein modifications, microscale in-gel tryptic digestion, MALDI MS/MS identification from in-gel digest, MS/MS of purified peptides and proteins, protein identification via database retrieval from nano LC-MS/MS in-gel tryptic digest information, proteomics methods development and consultation, RP-HPLC mapping of peptides from in-gel digests with MS/MS or ESI MS/MS of spectral peaks, targeted analyses of specific molecules with multiple reaction monitoring (MRM) and related techniques with triple quadrupole mass spectrometry.
Uma Aryal
Email This Core
(765) 496-4960
Director: Uma Aryal, Ph.D.
Innovative methodologies and technologies are developed in the Purdue Proteomics Facility (PPF), a shared facility of the Bindley Bioscience Center (BBC) and the Purdue Cancer Center. This facility enables never-before-possible analysis of post-translational modifications of the proteome. Coupled with new proteomics infrastructure and expert scientific researchers, these facilities provide unique approaches to intact protein (‘top-down’) and peptide fragment (‘bottom-up’) analyses. Many projects in Bindley Bioscience Center employ these technologies for biomarker discovery in health and disease – a signature research area at the BBC. Capabilities – Amino acid analysis of peptides or proteins, automated and manual computer search and analyses, bioinformatic consultation, equipment and software for complete 2D gel analyses, ESI analysis of intact proteins, high throughput comparative proteomics with LCMS-MS/MS, identification and characterization of peptide and protein modifications, microscale in-gel tryptic digestion, MALDI MS/MS identification from in-gel digest, MS/MS of purified peptides and proteins, protein identification via database retrieval from nano LC-MS/MS in-gel tryptic digest information, proteomics methods development and consultation, RP-HPLC mapping of peptides from in-gel digests with MS/MS or ESI MS/MS of spectral peaks, targeted analyses of specific molecules with multiple reaction monitoring (MRM) and related techniques with triple quadrupole mass spectrometry.
Uma Aryal
Email This Core
(765) 496-4960
Purdue Transgenic Mouse Core Facility
Stephen Konieczny, Ph. D
Email This Core
Purdue Translational Pharmacology Facility
Director: Greg Knipp
Manager: Robyn McCain
Email This Core
765.496.6147
Affiliation:
Regenstrief Institute
Director: Timothy Imler
Manager, Data Core Services: Faye Smith
Program Manager, Data Core Services: Katie Allen
Assistant Manager: Anna Roberts
The Regenstrief Institute Data Core, under the leadership of Dr. Timothy Imler MD, MS, provides services and resources through the CTSI Informatics and Data Analysis Core (CIDAC) to assist investigators with research utilizing the Indiana Network for Patient Care (INPC).
Completeness of data varies across each INPC institution and approval to use individual institutions’ data may be required.
The Indiana CTSI and Regenstrief Institute cooperate to provide a limited amount of funding to support the data infrastructure to assist with developing grant proposals, feasibility assessments, and unfunded studies. Remaining Data Core expense is offset by awarded grants, contracts, and other external funding.
Cindy Majors, Administrative Assistant
Email This Core
317-274-9153
Director: Timothy Imler
Manager, Data Core Services: Faye Smith
Program Manager, Data Core Services: Katie Allen
Assistant Manager: Anna Roberts
The Regenstrief Institute Data Core, under the leadership of Dr. Timothy Imler MD, MS, provides services and resources through the CTSI Informatics and Data Analysis Core (CIDAC) to assist investigators with research utilizing the Indiana Network for Patient Care (INPC).
Completeness of data varies across each INPC institution and approval to use individual institutions’ data may be required.
The Indiana CTSI and Regenstrief Institute cooperate to provide a limited amount of funding to support the data infrastructure to assist with developing grant proposals, feasibility assessments, and unfunded studies. Remaining Data Core expense is offset by awarded grants, contracts, and other external funding.
Cindy Majors, Administrative Assistant
Email This Core
317-274-9153
Affiliation:
Indiana Genomics Initiative (INGEN), IU Simon Cancer Center, IU School of Medicine
Director: Loren Field, Ph D.
Production of transgenic mouse lines using both blastocyst injection of embryonic stem cells and pronuclear injection of DNA.
Hanying Chen
Email This Core
(317) 278-0163
Director: Loren Field, Ph D.
Production of transgenic mouse lines using both blastocyst injection of embryonic stem cells and pronuclear injection of DNA.
Hanying Chen
Email This Core
(317) 278-0163
Affiliation:
Indiana University School of Medicine
Director: Kieren Mather, MD
Associate Director: Robert Considine, Ph.D.
The Translation Core provides services that reduce or eliminate barriers to conducting research involving human subjects. Services include metabolic phenotyping (e.g. GTT, clamp studies, tracer studies), measurements of blood analytes (e.g. hormones, cytokines, lipids), maintenance of a biobank of human tissues and serum, and a host of specialized and customizable laboratory services.
Kieren Mather
Email This Core
317-278-7826
Director: Kieren Mather, MD
Associate Director: Robert Considine, Ph.D.
The Translation Core provides services that reduce or eliminate barriers to conducting research involving human subjects. Services include metabolic phenotyping (e.g. GTT, clamp studies, tracer studies), measurements of blood analytes (e.g. hormones, cytokines, lipids), maintenance of a biobank of human tissues and serum, and a host of specialized and customizable laboratory services.
Kieren Mather
Email This Core
317-278-7826
Translational Genomics Laboratory
Director: Sunil Badve, MD
The Translational Genomics Laboratory provides services for 1) nucleic acid preparation, 2) genotyping, and 3) gene expression profiling.
Sunil Badve, MD
Email This Core
(317) 491-6417 (office)(317) 274-5565 (laboratory)
Affiliation:
IU School of Medicine
Director: Kenneth Cornetta, MD
Provide retroviral and lentiviral therapy vectors for clinical use and provide reagents and training to investigators seeking research grade reagents. Testing is also available for assistance in clinical gene therapy.
Learn More
Ken Cornetta
Email This Core
(317) 278-195
Director: Kenneth Cornetta, MD
Provide retroviral and lentiviral therapy vectors for clinical use and provide reagents and training to investigators seeking research grade reagents. Testing is also available for assistance in clinical gene therapy.
Learn More
Ken Cornetta
Email This Core
(317) 278-195
Veterinary Clinical Trials Support Service
Director: George E. Moore, DVM, PhD, DACVIM
Trial Coordinator: Becky Bierman, RVT, BS
The Veterinary Clinical Trials Support Service (VCT) facilitates veterinary clinical trials within the Purdue Veterinary Teaching Hospital and provides expertise and technical support for translational clinical investigations using animal models of spontaneous, naturally-occurring diseases in client-owned animals and for trials leading to novel drugs or devices. Patients are actively recruited for clinical trials in the ongoing effort to improve both human and animal health and health care.
Veterinary Clinical Trials
Email This Core
(765) 496-9715
