Our Services include:
ADME-toxicology Studies
Tier 1 Screening assays:
Solubility assay, CYP SP inhibition assay
Metabolic assay, Ames screen
Tier II screening assays:
Permeability assay, CYP IC 50 assays, CYP3A4 TD1 Assays, Plasma Protein binding assay, Hepatocytic clearance assay, hERG (Cardiac toxicity)
Screening package:
Candidate Screening Package (Membrane Permeability and P gp Assessment, Metabolic Stability, and Rat
Tier III screening assays:
in-vivo models- Rat PK, Rat Cassette PK, Mouse PK, Mouse cassette PK, A Single Dose Oral Gavage Pilot Toxicity Study in Rats, Dose Formulation Optimization and Dose-ranging study in Beagle dogs
Custom Chemical Library Synthesis
We offer high quality and cost-effective custom library synthesis services of both large diversity libraries and focused libraries, including milligram quantities of a metabolite or several kilograms of a scaffold.
Covance/Eurofins Services:
- PK and Toxicology services
- Ames,
- rat and beagle toxicology screens,
- hERG,
- metabolic stability,
- rat PK
Services from Q2 Solutions:
- In-vitro ADME services
- solubility,
- permeability,
- microsomal stability,
- logP