Review: Acute cerebral stroke with multiple infarctions and COVID-19, France, 2020

This case series described two patients who were infected with SARS-CoV-2 who had thrombotic strokes during ongoing anti-coagulation treatment for atrial fibrillation stroke prophylaxis. 

  • Both cases involved men, ages 74 and 84 years old, each with multiple cardiovascular diseases, including atrial fibrillation. Both adequately treated for this condition.
  • Patient 1 was admitted for respiratory symptoms, diagnosed with COVID-9. On Day 9, having neurological symptoms and brain MRI revealed acute ischemic stroke in multiple vascular areas. his conditional worsened and he died on Day 18 of hospitalizations.
  • Patient 2 was admitted for influenza-like illness and confusion. COVID-9 positive. Had nonfluent aphasia at admission. Brain CT scan revealed many recent ischemic infarctions in different vascular areas, and brain MRI  confirmed this finding
  • Neither patient had non–central nervous system thrombotic events (e.g., pulmonary embolisms, abdominal visceral infarction)
  • Given the increasing realization that COVID-19 might be associated with hypercoagulability, the concurrent presence of anti-coagulation with direct oral anticoagulants should not be reassuring as preventive.
|2020-05-28T11:41:59-04:00May 27th, 2020|COVID-19 Literature|Comments Off on Review: Acute cerebral stroke with multiple infarctions and COVID-19, France, 2020

About the Author: Megan McHenry

Megan McHenry
Megan S. McHenry, MD, MS, FAAP is a pediatrician and an Assistant Professor of Pediatrics in the Ryan White Center for Pediatric Infectious Disease and Global Health at Indiana University School of Medicine. Dr. McHenry's research focuses on early childhood development in children living in resource-limited settings. This work is frequently aligned with community-engaged research and dissemination and implementation science frameworks. She primarily conducts research in collaboration with the Academic Model for Providing Access to Healthcare (AMPATH) Research Network in Kenya. Dr. McHenry currently has a career development award through the National Institutes of Health to develop a neurodevelopmental screening program for children born to HIV-infected mothers in Kenya. Dr. McHenry is also the Director of Pediatric Global Health Education and a co-Director of the Morris Green Physician-Scientist Development Program at Indiana University School of Medicine. In additional to global health lectures, she also educates residents and students on early childhood development, basic biostatistical techniques, research methodologies, and research ethics. She mentors multiple pediatric fellows, residents, and medical students interested in early childhood development within global contexts.

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