This editorial argues that researchers need to be transparent and acknowledge what is known and unknown to tackle disinformation.

A resurgence of misinformation and disinformation has come to the forefront as people begin to question the safety of proposed vaccines for COVID-19, the security of contact-tracing apps, and how intellectual property rights and profits will be shared. Lessons from previous communication efforts on emerging research information are clear:
• Do not over-promise
• Do not over-sell
• Emphasize what is known and what is not known
• Be transparent about what works, how it works, and possible risks
Researchers need to respond to misinformation and disinformation by building a community that is resilient to falsehoods about COVID-19.