Review: Diagnosis of the coronavirus disease (COVID-19): rRT-PCR or CT?

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Review: Diagnosis of the coronavirus disease (COVID-19): rRT-PCR or CT?

Review: Diagnosis of the coronavirus disease (COVID-19): rRT-PCR or CT?

This study showed that rRT-PCR may produce initial false-negative results. Combining this with other testing modalities may improve sensitivity.

Our data on testing are still relatively new. This was a retrospective cohort study of 36 patients suspected of infections with COVID-19 who were examined by both CT and rRT-PCR at initial presentation. The sensitivities of both tests were compared.

Thirty-five patients had abnormal CT findings at presentation; only one patient had a normal CT. Using rRT-PCR, 30 patients were tested positive, with 6 negative. Three of the six became positive after a second rRT-PCR assay 2-3 days later, and the other 3 became positive after a third rRT-PCR tests 5-8 days later.

At presentation, CT sensitivity was therefore 97%, compared to a sensitivity of initial rRT-PCR of only 83%.

|2020-04-02T11:50:02-04:00April 2nd, 2020|COVID-19 Literature|Comments Off on Review: Diagnosis of the coronavirus disease (COVID-19): rRT-PCR or CT?

About the Author: Aaron Carroll

Aaron Carroll

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