The Metabolite Profiling Facility (MPF) provides state-of-the-art technologies that enable both qualitative Metabolite (efforts to define or catalog all components of a metabolome) and quantitative Metabolite (understanding differential concentrations of metabolites) for metabolite profiling in biological systems. This facility employs highly sensitive mass spectrometry coupled with multi-dimensional gas and liquid chromatography (GC and LC-MS) to provide researchers with new technologies and methods development, as well as expert training and consultation. This research capability allows assessment of the hierarchical flow of information from the genome to the transcriptome, proteome, and metabolome ultimately defines cellular phenotypes.
- * High throughput metabolite profiling with LC-MS, LC/MS, MS, GC/MS or GCxGC-MS * Complete training in Metabolite technologies * Identification and characterization of small molecules * Automated and manual sample preparation and Solid Phase Extraction (SPE) * Metabolite methods development and consultation * Bioinformatic consultation * Various off-line HPLC separations and small molecule isolation * Automated and manual computer search and analyses
Waters Micromass LCT Premier (TOF), Waters Micromass Q-Tof micro, Agilent MSD/TOF, LECO Pegasus 4D GCxGC-TOF
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