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Chemical Genomics Facility (CGF)

Chemical Genomics Facility (CGF)

Affiliation :  Purdue University

Director:   Zhong-Yin Zhang, PhD.
Manager:   Lan Chen, PhD.

Website:  https://www.purdue.edu/discoverypark/drug-discovery/resources/cgf/index.php

Description:
The Chemical Genomics Facility (CGF) provides affordable access to large chemical and CRISPR libraries and state-of-the-art instrumentation in high-throughput screening (HTS) and high content screening (HCS) campaigns. The facility also provides assistance in assay development and hit validation using various biophysical approaches.

Policies: Services Offered:
  • Assay implementation and optimization of various biochemical assays of enzyme activity, protein-protein interaction and cell-based reporter gene assays and phenotypic assays
  • Chemical libraries of over 500,000 compounds categorized into diversity-based, targeted, natural products, known drugs, bioactives, fragments libraries
  • siRNA libraries of human kinase and phosphatase, and arrayed human genome CRISPR library
  • Robotic equipment such as liquid handling workstations, dispensers, plate readers, high content imaging system etc.
  • Hit validation using Isothermal Titration Calorimetry (ITC), MicroScale thermophoresis (MST), thermal shift assay (TSA), and Functional Drug Screen System (FDSS) mCell for ion channel, GPCR Ca2+ assays
Contact Information:
Dr. Lan Chen
Email This Core
765-496-6668

|2021-10-14T10:08:23-04:00October 15th, 2021|Comments Off on Chemical Genomics Facility (CGF)

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