Zhong-Yin Zhang, PhD.
Associate Director: Lan Chen, PhD.
The Chemical Genomics Facility\\\\\\\\’s (CGF) mission is to provide expertise and resources to investigators from Purdue and other institutions to access state-of-the- art technologies and instrumentation in high-throughput screening (HTS) and high content screening (HCS), to facilitate the identification of chemical or genomic tools to study biological pathways and the discovery of lead agents for the development of novel therapeutics and diagnostic approaches. The facility is designed to be highly flexible in order to meet the needs of multiple users employing a range of assays from a wide range of disciplines. Our experienced facility staff work closely with each investigator and provide services through all stages of the lead discovery process.
- Consultation on assay development, implementation, validation and miniaturization specific to the target of your interest. Type of assays implemented includes: –In vitro enzymatic activity assays –In vitro protein binding assays –Cell proliferation assays –Cell-based transcription (reporter gene) assays –Image-based cell phenotypic screening assays
- Pre-plated compound library ready for assays that are performed in 384-(preferred) or 96-well plate format
- High throughput screening and high content screening using liquid handling robots and automated plate readers and high content imaging acquisition and analysis
- Assistance with data analysis and compound selection will be provided as needed
- Post-screen hit validation (dose dependence, binding evaluation, etc.)
high-throughput screening (HTS), high-throughput screening (HTS), high content screening (HCS), high content screening (HCS), biological pathways, biological pathways, discovery, discovery, lead agents, lead agents, novel therapeutics, novel therapeutics, assays, assays, diagnostics, diagnostics, genomics, genomics, chemical, chemical
Dr. Lan Chen
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