Weekly Review: Clinical Studies – August 10, 2020

Case reports:

A case report of early-onset, severe COVID-19 infection in a neonate was published, suggestive of vertical transmission.

Another case report describes an infant who present with incomplete Kawaski Disease as their primary symptoms of COVID-19 infection.


Within a small cohort of 50 patients treated with hydroxychloroquine (600mg/d for 10 days) and azithromycin (500mg/d on Day 1 and 250mg/d from days 2-5), 38 (76%) had short-term modifications of the QTc duration (>30ms). Treatment was discontinued in 6 patients (12%), and their QTc normalized in 5 of the 6. Cardiac monitoring should be regularly performed and patient treated with hydroxychloroquine and azithromycin.

|2020-08-11T08:08:35-04:00August 10th, 2020|COVID-19 Literature|Comments Off on Weekly Review: Clinical Studies – August 10, 2020

About the Author: Megan McHenry

Megan McHenry
Megan S. McHenry, MD, MS, FAAP is a pediatrician and an Assistant Professor of Pediatrics in the Ryan White Center for Pediatric Infectious Disease and Global Health at Indiana University School of Medicine. Dr. McHenry's research focuses on early childhood development in children living in resource-limited settings. This work is frequently aligned with community-engaged research and dissemination and implementation science frameworks. She primarily conducts research in collaboration with the Academic Model for Providing Access to Healthcare (AMPATH) Research Network in Kenya. Dr. McHenry currently has a career development award through the National Institutes of Health to develop a neurodevelopmental screening program for children born to HIV-infected mothers in Kenya. Dr. McHenry is also the Director of Pediatric Global Health Education and a co-Director of the Morris Green Physician-Scientist Development Program at Indiana University School of Medicine. In additional to global health lectures, she also educates residents and students on early childhood development, basic biostatistical techniques, research methodologies, and research ethics. She mentors multiple pediatric fellows, residents, and medical students interested in early childhood development within global contexts.

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