This brief from Nature discusses mass vaccinations and its effects on the spread of COVID-19 in children. Data from the small town of Serrana in the Brazilian state of Sao Paulo indicate that adult vaccinations are a protective factor against infection spread in children. In the town, 98% of adults have been vaccinated with CoronaVac and the town is the site of Project S, which measures the effectiveness of the vaccine. The most recent data revealed that symptomatic cases dropped by 80% and mortality by 95%. A similar reduction was seen in unvaccinated children. This is a very interesting finding as only 62% of the town’s 45,000 residents are adults. Israel and the U.S. have also seen similar reductions. In England, however, data suggests that children might still be important spreaders as during the month of May, there were nearly 100 outbreaks in primary and secondary schools. Researchers conclude that schools most likely are not hotpots for infection spread. This is seen by worldwide data which indicate that outbreaks in schools since the onset of the pandemic have been uncommon even when there were high levels of community infection. There are mixed reactions regarding whether children should be vaccinated for a disease where severe infection is rare. Others, however, see the need to vaccinate children as this would be a crucial step in controlling the pandemic.