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COVID Cuts: A brief summary of this week’s COVID-19 clinical research

COVID Cuts: A brief summary of this week’s COVID-19 clinical research

Vaccine Update: 

The mRNA-1273 vaccine (from Moderna and NIAID) induced anti-SARS-COV-2 immune responses (anti-Spike-2P glycoprotein antibody) in all participants and no trial-limiting safety concerns were identified.

Epidemiology:

During hospital-wide SARS-CoV-2 antibody (Ab) screening in healthcare workers (HCW) and staff in Belgium, 6.4% had IgG antibodies for SARS-CoV-2

During hospital-wide SARS-CoV-2 Ab screening in HCW and staff at Mass Gen Hospital (performed in 3 phases), 12.9% had positive results for SARS-CoV-2, and universal masking policy was associated with a significantly lower rate of SARS-CoV-2

Overall SARS-CoV-2 PCR- positivity rates of HCW in a pediatric setting in Paris was 2.3% (compared to 2.8% in an associated adult setting)

Treatment:

Within a retrospective review of critically ill adults with SARS-CoV-2 pneumonia, no difference was found between hydroxychloroquine or lopinavir/ritonavir compared to standard of care

Case Reports: 

Child with Guillain-Barre syndrome after COVID-19

Child receiving remdesivir during induction chemotherapy for newly diagnosed pediatric acute lymphoblastic leukemia with concomitant SARS-CoV-2 infection

Child with oral ulceration as an early feature of multisystem inflammatory syndrome in children (MIS-C)

Two children with COVID-19 positive PCR swab upon MIS-C presentation

Immunology:

Humoral and circulating follicular helper T cell responses in a cross-sectional adult cohort who had recovered from COVID-19 infection

Description of a rapid antibody discovery platform that isolated hundreds of human monoclonal antibodies again SARS-CoV-2 spike protein

SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls

Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients

 

|2020-07-17T11:56:24-04:00July 17th, 2020|COVID-19 Literature|Comments Off on COVID Cuts: A brief summary of this week’s COVID-19 clinical research
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