Translational Research Development Program
The Indiana Clinical and Translational Sciences Institute (CTSI) is a vital partnership among the leading research universities of Indiana University, Purdue University and the University of Notre Dame as well as life sciences, businesses and community organizations across the state.
To fulfill its mission, it supports individuals and teams in all areas of translational research related to the prevention, diagnosis, and management of human disease.
A current list of current awardees is below to provide examples of the type of projects that the CTSI has invested to help improve human health, as well as to showcase the translational research being done across Indiana.
Current Translational Research Awardees
Program Page Links |
|---|
2022 – Biomedical Research Grant (BRG) |
||
|---|---|---|
| Bopda Waffo, Alain | IUSM | A Novel Biosensor to Monitor the Vaccine Efficacy of Coronavirus Diseases |
| Burgin, Sarah | IUSM | An assessment of molecular diagnostics in otitis media |
| Dahl, Richard | IUSM | MiRNA Programming of the Myeloid anti-Tumor Response |
| Elmendorf, Jeffrey | IUSM | Refining the molecular basis of insulin resistance & diabetes |
| Harrison, Nicholas | IUSM | Central Apnea as a mediator of Right Ventricular-pulmonary vascular uncoupling in Acute Heart Failure (CARV-AHF) |
| Maiers, Jessica | IUSM | Elucidating the crucial role of ER proteostasis in Hepatic Fibrogenesis |
| Mayo, Lindsey | IUSM | Mdm2 E3 neddylating activity drives the initiation of metastasis |
| Nelson, Rick | IU | Function of TMPRSS in Genetic Hearing Loss |
| O’Hagan, Heather | IUSM | Using lysine demethylase 1 inhibition to target enteroendocrine cells in mucinous colorectal cancer |
| Pin, Fabrizio | IU | Deletion of FNDC5/Irisin protects against cancer-induced cachexia syndrome |
| Richer, Martin | IUSM | Regulation of T cell differentiation by the transcription factor AFF3 |
| Robinson, Christopher | IU | The CD8 T cell response to Coxsackievirus B3 |
| Schwantes-An, Tae-Hwi | IUSM | Enhancing risk stratification for survival in PAH: Development of Polygenic Risk Scores |
| Tran, Ngoc Tung | IUSM | CRISPR/Cas9-based correction of FANCC mutations for Fanconi Anemia group C gene therapy |
| Wang, Meijing | IUSM | Sex-related differences in cardiac mitochondrial responses to inflammation following acute injury |
| Yoder, Rachel | IUSM | Pilot Assessment of Integrated Mental Health Treatment for Children and Caregivers |
2020 – Biomedical Research Grant (BRG) |
||
|---|---|---|
| Absalon, Sabrina | IUSM | Functional investigation of key regulatory proteins in the completion of cell division in malaria parasites. |
| Biswas, Moanaro | IUSM | Engineered TRuC Tregs to prevent germinal center responses to clotting factor VIII in hemophilia |
| Cornett, Evan | IUSM | Regulation of the circadian clock by lysine methylation |
| DeSmet, Marsha | IUSM | Mechanistic Role of Brd4 during Human Papillomavirus Replication |
| Takagi, Yuichiro | IUSM | Structure and function of Mediator CDK8 module |
2022 – Community, Healthcare Delivery & Implementation Science PDT |
||
|---|---|---|
| Johns, Shelley | IUSM | Telephone Acceptance and Commitment Therapy Intervention for Caregivers (TACTICs) of Adults with Alzheimer’s Disease and Related Dementias: Pilot RCT |
| Vest, Joshua CHDIS 1 | IUPUI | Translating existing electronic data into computable social factor phenotypes |
| Vest, Joshua CHDIS 2 | IUPUI | IUCRC Phase 1: Center for Population Health Analytics & Technology (CPHAT) |
2022 – Concepts to Clinic PDT |
||
|---|---|---|
| Ballinger, Tarah | IUSM | Impact of mechanical signals on bone and muscle composition in early stage breast cancer patients receiving aromatase inhibitors |
| Brutkiewicz, Randy | IUSM | Modulating Neuroinflammation After Spinal Cord Injury |
| Callaghan, Tom | IUSM | Addressing the Musculoskeletal Phenotype in Hypermobile Ehlers-Danlos Syndrome: Biomarker Pilot Study |
| Coggan, Andrew | IUPUI | Kynurenine and NAD+ as Biomarkers of ICU Acquired Weakness in Older Adults |
| Corson, Tim | IUSM | Efficacy studies of SH-11037, a therapy for neovascular eye disease |
| Gupta, Kunal | IUSM | RNA sequencing of the whole dentate gyrus in early temporal lobe epileptogenesis |
| Hall, Mark | Purdue | Cdc14 phosphatase roles in fungal drug resistance and pathogenesis |
| Hato, Takashi | IUSM | Mechanisms of sepsis-induced organ failure |
| Jackman, Christopher | IUSM | Bone effects of anti-CGRP medications for Migraine |
| Khan, Babar | IUSM | Improving sleep in acute respiratory failure ICU survivors |
| Lasagna-Reeves, Cristian | IUSM | The role of Bassoon on pathological tau propagation in Alzheimer’s disease (AD) and other Tauopathies |
| Lockett, Angelia | IUSM | S1P Induces Activation of the Mitochondrial Unfolded Protein Response to Promote Vascular Cell Proliferation in PAH |
| Maiers, Jessica | IUSM | Elucidating the role of ATF6a as a critical pro-fibrogenic transcription factor in Hepatic Stellate Cells |
| Niziolek, Paul | IUSM | MRI Determination of Femoral Neck Cortical Porosity in Chronic Kidney Disease Metabolic Bone Disease (CKD-MBD) |
| Plotkin, Lilian | IUSM | Gonadal vs chromosomal sex and osteocytic miR21 in the control of bone mass and strength |
| Tran, Taun | IUSM | Evaluating the dynamics and function of naturally acquired humoral immune responses to Plasmodium vivax vaccine candidate antigens in a longitudinal study |
2020 – Concepts to Clinic PDT |
||
|---|---|---|
| Lu, Xin | UND | Generation of HA-tagged PYGO2 CRISPR knock-in mice at Jackson Laboratory |
2021 – Core Pilot |
||
|---|---|---|
| Adeoye-Olatunde, Omolola | Purdue | Social Determinants of Health and Medication Adherence among Chronically Ill Older Adults in the United States |
| Chang, Leifu | Purdue | Mechanisms for inhibition of the Csy complex by anti-CRISPR proteins |
| Cross, Tzu-Wen | Purdue | Link between gut microbiome and brain proteome relevant to Parkinson’s Disease pathology |
| Datta, Meenal | UND | The myeloid “mechanome”: Identifying new treatment targets in glioblastoma |
| De Luca, Thomas | IUSM | Spatial metabolomics of sepsis-induced kidney injury in the diabetic milieu |
| Ejendal, Karin | Purdue | Analysis of the developing proteome in a mouse model of autism spectrum disorder |
| Engle, Staci | IUPUI | Role of hedgehog signaling in energy homeostasis and obesity |
| Gangopadhyay, Ishanti | IUB | Word learning mechanisms in bilingual children with Autism Spectrum Disorder: The use of social-pragmatic cues |
| Hall, Mark | Purdue | Proteomic characterization of Cdc14 phosphatases in fungal pathogens |
| Howe, Erin | UND | Identification of the Rab11 interactome |
| Kacena, Melissa | IUSM | Skeletal Changes Following SARS-CoV-2 Infection |
| Kirchmaier, Ann | Purdue | Metabolic Impacts on DNA Repair |
| Kitase, Yukiko | IUSM | Osteocyte Energy Metabolism Under Mechanical Loading |
| Malek, Sarah | Purdue | Fourier-transform infrared spectroscopy as a potential diagnostic and predictive biomarker of hip osteoarthritis |
| McDowell, Mary Ann | UND | Transcriptomics to Elucidate Methods of Lab-Induced Drug Resistance in Leishmania donovani |
| O’Hagan, Heather | IUB | Elucidating the role of the AKT-EZH2-ß-catenin axis in mediating the transcriptional response to reactive oxygen species in colorectal cancer |
| Pattabiraman, Padmanabhan | IUSM | Small Molecule screen to identify novel activators to lower intraocular pressure |
| Schmidt, Nathan | IUSM | Microbiome Impact in the Susceptibility of Red Blood Cell to Malaria Infection |
| Schorey, Jeff | UND | Identifying to the species and subspecies level the non-tuberculosis mycobacteria present in sputum samples obtained from patients in Kenya, Africa |
| Shannahan, Jonathan | Purdue | Enhanced Resolution of Pulmonary Lipid Alterations via Mass Spectrometry Imaging |
| Subramanian, Ramaswamy | Purdue | Structure of Glycosomal Nucleotide Sugar Transporter – A Novel Target Against Disease-Causing Kinetoplastid parasites |
| Tesini Roseguini, Bruno | Purdue | Home-based leg heat therapy to combat age-related loss of skeletal muscle mass and function |
| Zhang, Siyuan | UND | Dissecting Breast Cancer and Therapy-induced Evolution of Myeloid Lineage by CITEseq |
2020 – Core Pilot |
||
|---|---|---|
| Baker, Lane | IUB | Blood Brain Barrier Model |
| Bruzzaniti, Angela | IUPUI | Bone-cell specific actions of Kalirin |
| Chan, Deva | Purdue | Multi-Modal Magnetic Resonance Imaging for Functional Assessment of Tissue Repair |
| Clapp, David | IUSM | FANCA-Dependent Mitotic Interactions |
| Daleke, David | IUB | Toward the cryo-EM structure of a P4-type ATPase monomer, Atp8a1 |
| Das, Arupratan | IUSM | Isolation and Characterization of Mitochondria to Investigate Mitochondrial Optic Neuropathy |
| Demas, Gregory | IUB | Steroidogenic Enzyme Regulation of Aggression |
| Dykhuizen, Emily | Purdue | The Role of Polybromo1 (PBRM1) Loss in Checkpoint Inhibition Immunotherapy for Renal Cell Carcinoma |
| Elmendorf, Jeffrey | IUSM | Imaging skeletal muscle insulin resistance in live mice |
| Fishel, Melissa | IUSM | Pre-clinical pilot study to evaluate non-cytotoxic epigenetic therapy for pancreatic cancer |
| Gao, Ming | IU NW (Gary) | Analysis of RNA Helicase Me31B and Its Interacting RNAs by RNA sequencing |
| Gavin, Tim | Purdue | Aging and skeletal muscle exosome miRNA-seq |
| Hoang, Quyen | IUSM | High-throughput chemical screening against the Parkinson’s disease-associated protein LRRK2 |
| Kalinovsky, Anna | IUB | Effects of Phytocannabinoids on Cerebellar Axon Growth and Fasciculation |
| Lu, Hui-Chen | IUB | Elucidate NMNAT2’s roles in brain health with longitudinal PET-MRI |
| Lu, Kun-Han | Purdue | 4D MRI assessment of gastric motility after selective vagotomies in rats |
| Lu, Xin | Notre Dame | Go Keto: A New Paradigm to Enhance Cancer Immunotherapy |
| Naidu, Samisubbu | IUSM | Induction of Mitophagy in Endothelial Cells from Pulmonary Arterial Hypertension |
| Newton, Irene | IUB | Understanding Bifidobacterium’s Presence in Infants Using Novel Sequencing |
| Noinaj, Nicholas | Purdue | Unraveling zinc piracy in Neisseria |
| Pestilli, Franco | IUB | Development and Validation of a Visual Field Mapping Protocol in Children |
| Snyder, Margie | Purdue | Feasibility Pilot of Linking Patient-Reported Outcomes Collected in Community Pharmacies with Electronic Health Record Data |
| Takagi, Yuichiro | IUSM | Structure of the Mediator complex of transcription regulation |
| Tang, Pei-Ciao | IUSM | Regulation of Early Ectodermal Development |
| Thompson, William | IUPUI | Generation of a Novel Mouse Model to Restore/Overexpress the a2d1 VSCC Subunit |
| Tisdale, James | Purdue | Risk of Drug-Induced QT Interval Prolongation and Associated Proarrhythmia in Patients with Heart Failure with Preserved Ejection Fraction |
| Walczak, Claire | IUB | Single Cell Seq to Identify Heterogeneity in Polyploid Cells |
| Warden, Stuart | IUPUI | Impact of physical activity on hip bone and cartilage health |
| Yang, Danzhou | Purdue | Structure Study of Nucleolin-MYC promoter DNA G-quadruplex Complex |
| Ziarek, Joshua | IUB | Molecular mechanisms of arrestin activation |
2022 – COVID-19 PDT |
||
|---|---|---|
| Agley, Jon | IUB | Pilot Study of a Brief Informational Intervention for COVID-19 Misinformation Prophylaxis |
| Connors, Jill | IUSM | Addressing Mental Health Needs of Health Care Workers through Peer Support Groups During the COVID-19 Crisis |
| Gletsu-Miller, Nana | IUB | Associations between Nutritional Status of Vitamin D, Iron and Magnesium and Disease Severity of COVID-19 |
| Kacena, Melissa | IUSM | The role of megakaryocytes in regulating COVID-19 disease progression: A mouse model |
| Lim, Kenneth | IUSM | Klotho-FGF23: Critical Biomarkers and Therapeutic Targets for Acute Kidney Injury (AKI) in COVID-19 |
| Maupome, Gerardo | IUPUI | Hispanic COVID-19 Rapid Response Study: Characterization of Knowledge, Attitudes and Behaviors about COVID-19 Pandemic among Hispanic Respondents in Indiana |
| Minor, Kyle | IUPUI | How COVID-19 Impacts Daily Life: Comparing Serious Mental Illness and Healthy Adult Populations Pre-Post Social Distancing |
| Wang, Sophia | IUSM | The Role of COVID-19 Endothelial Cell Dysfunction in Post-Intensive Care Unit (ICU) Depression and Anxiety Disorders |
2020 – COVID-19 PDT |
||
|---|---|---|
| Baker, Brian | UND | Interrogating SARS-CoV-2 CTL antigens for immunobiology and potential T cell based vaccine strategies |
| Eckardt, Christopher | Purdue | Ecological Momentary Assessment of Intimate Partner Violence During and After the COVID-19 Pandemic |
| Figueiredo, Marxa | Purdue | Developing Targeted Therapeutics for Protecting and Treating COVID-19 Lung Disease |
2022 – Collaboration in Translational Research (CTR) |
||
|---|---|---|
| Abebe, Ephrem | Purdue | OTC Senior Station: A Consumer Facing Technology to Improve Medication Safety for Older Adults |
| DePaoli-Roach, Anna | IUSM | Identification of New Lead Small Molecules for the Treatment of Glycogen Storage Disease Type III |
| Holden, Richard | IUB | OTC Senior Station: A Consumer Facing Technology to Improve Medication Safety for Older Adults |
| Honaker, Sarah | IUSM | Sleep, feeding, and obesity risk during infancy in African American and Latinx families |
| Jin, Xiaoming | IUSM | Brain epigenetic mechanism of acupuncture on neuropathic pain |
| Lee, Jessica | IUPUI | Addressing Disparities in Autism Spectrum Disorder (ASD) among Burmese Refugee families in Central Indiana |
| Logrip, Marian & Lukkes, Jodi | IUPUI/IUSM | Adolescent social isolation effects on alcohol drinking & neuroadaptations in dorsal raphe-basolateral amygdala circuit |
| Lu, Tao | IUSM | Improving the potency of novel PRMT5 inhibitor with nanocrystal technology to treat pancreatic cancer |
| Moding, Kameron | Purdue | Sleep, feeding, and obesity risk during infancy in African American and Latinx families |
| Otte, Andrew | Purdue | Long-acting ketamine for pain due to bone fracture |
| Patel, Rita & Gupta, Kunal | IUB/IUSM | Deep brain stimulation for laryngeal dystonia: from mechanism to optimal application |
| Taylor, Rich | UND | Identification of New Lead Small Molecules for the Treatment of Glycogen Storage Disease Type III |
| White Fletcher | IUSM | Long-acting ketamine for pain due to bone fracture |
| Yuan, Chongli | Purdue | Brain epigenetic mechanism of acupuncture on neuropathic pain |
| Zhou, Xiang | Purdue | Addressing Disparities in Autism Spectrum Disorder (ASD) among Burmese Refugee families in Central Indiana |
2021 – Collaboration in Translational Research (CTR) |
||
|---|---|---|
| Ferradal, Silvina | IUB | Early prediction of withdrawal in infants with prenatal opioid exposure using quantitative measurements |
| Goni Cortes, Joaquin | Purdue | Uncovering fingerprints of brain network flexibility in alcohol use disorders |
| Guo, Feng | IUB | A Tumor-on-a-Chip Platform for Modeling Immuno-Oncology in Prostate Cancer |
| Han, Bumsoo | Purdue | Application of a biomimetic model to assess the effects of perfluoroalkyl substances (PFAS) on pancreatic cancer |
| Hocevar, Barbara/Kamendulis, Lisa | IUB | Application of a biomimetic model to assess the effects of perfluoroalkyl substances (PFAS) on pancreatic cancer |
| Kareken, David | IUSM | Uncovering fingerprints of brain network flexibility in alcohol use disorders |
| Lu, Xin | Notre Dame | A Tumor-on-a-Chip Platform for Modeling Immuno-Oncology in Prostate Cancer |
| O’Sullivan, Thomas D. | Notre Dame | Early prediction of withdrawal in infants with prenatal opioid exposure using quantitative diffuse optical spectroscopy |
| Raman, Subha / Stewart, Jesse | IU/IUPUI | Longer-Term Cardiovascular and Psychiatric Consequences of SARS-CoV-2 Infection: Prevalence and Insights into Shared Mechanisms. |
| Schlader, Zachary / Basile, David | IUB/IUSM | Heat waves, aging, and the kidneys |
2022 – Grant Linking Universitywide Expertise (GLUE) |
||
|---|---|---|
| Mitra, Anirban & Zhang, Chi | IUB/IUSM | Regulation of ovarian cancer metastatic colonization through clonal selection |
2022 – Human Health & Biomedical Technology PDT |
||
|---|---|---|
| Bowman, Adam & Rochet, Jean-Christophe | Purdue | Sex Differences in Neuropathology and Excitotoxicity in a Stem Cell Model of Alzheimer’s Disease |
| Das, Chittaranjan | Purdue | Identification of host targets of a bacterial effector with a novel deADP-ribosylase activity |
| Running, Cordelia & Gletsu Miller, Nana | Purdue | Trading Sugar for Sparkle |
2021 – Human Health & Biomedical Technology PDT |
||
|---|---|---|
| Bhunia, Arun | Purdue | Fate of LAP as Excipient during Drug Delivery |
| Cooks, Robert Graham | Purdue | Walk-up system to sample breath, perform MS and output Y/N respiratory infection status |
| DeMaria, Andrea | Purdue | Improving Overall Quality of Life for Uterine Fibroid Patients |
| Hu, Chang-Deng | Purdue | Cryo-EM Structural Analysis of PRMT5 in Complex with pINIn |
| Kimbrough, Adam | Purdue | Exploring sex differences in how the brain responds to oxycodone use |
| Yang, Yang | Purdue | The role of oxytocin in a mouse model of Scn2a deficiency |
2020 – Human Health & Biomedical Technology PDT |
||
|---|---|---|
| Cross, Tzu-Wen | Purdue | Gut microbiome and estrogen receptor signaling: potential implication on gastrointestinal-related disease |
| Foti, Daniel | Purdue | Developing a novel protocol for home-based electroencephalography assessment of families affected by Angelman syndrome |
| Roseguini, Bruno | Purdue | Heat therapy to improve skeletal muscle function in a model of Duchenne muscular dystrophy |
2021 – Lilly Stark Fellowship Postdoc |
||
|---|---|---|
| Dabin, Luke | IUSM | Single-nucleus epigenetic response to fast and slow rates of amyloid production in mouse brain |
| Fernandez, Anllely | IUSM | A novel neurodegenerative disease provides new insights intoamyloid-independent pathways in neurodegeneration. |
2021 – Lilly Stark Fellowship Predoc |
||
|---|---|---|
| Huang, Kang-Chieh | IUPUI | Modulation of Signaling and Autophagy in Glaucomatous Neurodegeneration from Human Pluripotent Stem Cell-Derived Retinal Ganglion Cells |
| Tsai, Andy | IUSM | Novel Therapeutic Targets for Alzheimer’s Disease |
2021 – Lilly Stark Postdoc Year 2 |
||
|---|---|---|
| Hallinan, Grace | IUSM | Atomic model of human tau filaments and tau propagation in Gerstmann-Sträussler-Scheinker disease |
2020 – Lilly Stark Postdoc Year 2 |
||
|---|---|---|
| Philtjens, Stephanie | IUSM | Identification of genetic modifiers for AD risk genes in the Diversity Outbred mouse model |
2021 – Lilly Stark Predoc Year 2 |
||
|---|---|---|
| Bharthur Sanjay, Apoorva | IUSM | A Novel Approach to Biomarker Development for Early Diagnosis and Prediction of Alzheimer’s Disease |
2022 – Neuroscience / Cancer PRMC |
||
|---|---|---|
| Engleman, Eric | IUSM | Modeling the interaction of alcohol and aging in Alzheimer’s disease |
| Lukkes, Jodi | IUSM | Neural mechanisms underlying the effects of adolescent social isolation on stress-related serotonergic systems |
| O’Leary, Heather | IUSM | Mechanisms and Targeting of Oxygen (O2) Mediated Calcium (Ca2+) Regulation in Malignant Hematopoietic Cells |
| Rietz, Anne | IUSM | A pilot study to determine the spatial transcriptome in the spinal cord of SMA and control mice at postnatal day 4 |
| Walker, Brian | IUSM | Abnormal RNA processing in the pathogenesis and treatment of multiple myeloma |
2022 – Obesity / Metabolism PRMC |
||
|---|---|---|
| Dong, Charlie | IUSM | PNPLA3 high-risk variant in alcoholic liver disease |
2020 – Pediatric Fellowship |
||
|---|---|---|
| Fairman, Korre | IUSM | Disrupted cardiogenesis in Shroom 3 loss-of-function mice embryos in vivo |
| Malin, Stefan | IUSM | Development of a Simulation-Based EMR Training Curriculum for Pediatric Resident |
| Severyn, Nicholas | IUSM | Lung development under hypoxic conditions in a rat model |
| Theisen, Alexandra | IUSM | The Evaluation of Ovarian Reserve Using Anti-Mullerian Hormone in Young Women Diagnosed with Systemic Rheumatic Disease Compared to Controls |
2021 – Pediatrics PDT |
||
|---|---|---|
| Aguilar, R. Claudio | Purdue | Evaluating therapeutic strategies against Lowe syndrome |
2022 – Pediatrics PDT |
||
|---|---|---|
| Rodriguiz, Gabriela | IUSM | Characterizing Usual Care for Youth with Disruptive Behavior Disorders in Indiana Community Mental Health Centers |
| Williams, Amy | IUSM | Examination of mechanisms contributing to impact of insomnia on chronic pain risk and outcomes in pediatric patients |
2020 – Pilot Funding |
||
|---|---|---|
| Clemmer, David | IUB | Developing Techniques for analysis of exosomes associated with wound healing |
2022 – Postdoc Challenge |
||
|---|---|---|
| Ahn, Taeyong | IUSM | The use of nano‐liquid chromatography (LC‐MS) mass spectrometry for the identification of potential protein biomarker candidates related to an anterior cruciate ligament (ACL) injury |
| Barboi, Cristina | IUPUI | Outcome analysis of intraoperative therapeutic interventions relative to the risk associated with progressive hypotension |
| Burke, Andrew | IUSM | Contribution of social circuits to social familiarity-induced anxiolysis |
| Gampala, Silpa | IUSM | Deciphering the effects of Ref‐1 redox inhibition on pancreatic cancer metabolism using non‐targeted global metabolomic profiling |
| Liffner, Benjamin | IUSM | Proximal labelling of a kinase to identify proteins involved in mitosis of malaria parasites |
| Ma, Jing | IUSM | Characterization of neutrophils-released EV-miRNA cargo in alcoholic hepatitis patients |
2021 – Postdoc Challenge |
||
|---|---|---|
| Chen, Xiaoling | Purdue | Optogenetic method for synaptic weight mapping |
| Yen, Yu-Chen | Purdue | Cryo-EM structure of adenylyl cyclase 5 in complex with Gβγ |
2020 – Research Enhancement Grant (REG) |
||
|---|---|---|
| Schwartz, Margaret | IUSM | Impact of Methionine Metabolism on lung disease of prematurity |
2021 – Sarah Roush |
||
|---|---|---|
| Gomes, Catia | IUSM | Inhibition of A1 astrocyte-induced neurodegeneration by targeting complement C3 |
2022 – Showalter |
||
|---|---|---|
| Biswas, Moanaro | IUSM | Targeting BAFF for modulation of adaptive immune responses to factor VIII replacement therapy |
| Bogatcheva, Natalia | IUSM | Small-molecule dual PARP1-PDL1 inhibitor as a mitigator of influenza-induced lung injury |
| Das, Arupratan | IUSM | Use of Human stem cell derived Retinal Ganglion Cells to investigate Nrf2 as therapeutic target for glaucomatous optic neuropathy |
| Janosevic, Danielle | IUSM | The study of transcription and translational mediators of sepsis-associated kidney injury in the diabetic milieu. |
| Lim, Kenneth | IUSM | The Myocardial Cytoskeleton in Chronic Kidney Disease (CKD) |
| Schlecht, Stephen | IUSM | Does the timing of ACL reconstructive surgery have an impact on long-term autograft outcomes? |
| Spaeth, Jason | IUSM | Dynamic regulation of Pdx1 and islet ß-cell function by the Nucleosome Remodeling and Deacetylase complex |
| Vilseck, Jonah | IUSM | Accelerating Structure-Based Lead Optimization with AI-Inspired Molecular Generation and Fast Free Energy Calculations |
| Zang, Yong | IUSM | Transparent and efficient dose-finding clinical trial designs for targeted therapies and immunotherapy |
| Zhang, Ji | IUSM | Regulation of iron-dependent histone demethylation by amino acid starvation |
| Zhang, Xinna | IUSM | Identification of epigenetic inhibitors to sensitive triple negative breast cancer to immunotherapy |
2022 – Trailblazer |
||
|---|---|---|
| Brandon-Friedman, Richard / Miller, Marissa | School of Social Work, IU and Trans Solutions Research and Resource Center, LLC | Pilot Testing the VISION Program to Enhance the Wellbeing of Transgender People of Color |
| Cecil, Kara / Stinson, Kelsey | University of Indianapolis, Kinesiology, Health, and Sport Sciences and CICOA Aging and In-Home Solutions | Hidden Families: Identification of and Assistance for Vulnerable Caregivers |
| Franks, Melissa / Riggin, Katrina | Purdue University Department of Human Development and Family Studies and IU Health Ball, Blackford and Jay Hospitals | Promoting Physical Activity Among Female Patients Following Cardiac Rehabilitation |
| Hernandez, Elaine / Hicks, Ivan | IUPUI, Sociology and First Baptist Church North Indianapolis | An Opportunity for Racial Equity in Health Care Access |
| Macey, Erin / Rusnak, Colleen | IUPUI, Social and Behavorial Sciences and Indiana Health Fund | Impact of Medical Debt Relief for Pregnant/Postpartum Women |
| Peterson, Zoe / Shipley, Meagan | Indiana University Counseling and Educational Psychology and IU Health | Healthy Relationships and Rural Youth: Evaluation of A Professional Development Training for Youth-Serving Adult Mentors |
| Tucker-Edmonds, Brownsyne / Voisard, Andrea | IU School of Medicine, Department of Obstetrics and Gynecolory and Goodwill of Central and Southern Indiana Nurse-Family Partnership | Understanding birth team dynamics at Eskenazi Health and birth outcomes of Medicaid recipients who are MDwise members served by doulas |
2021 – Trailblazer |
||
|---|---|---|
| Galaviz, Karla / Stowers, Jill | Indiana University School of Public Health and IU Health, Bloomington | Peer Recruitment in HIV Prevention |
| Gregory, Virgil / Muhammad, John | IUPUI School of Social Work and Fathers and Families Center | A Community Partner-University Collaboration for Increasing African American Men’s Access to Professional Mental Health Services: A Structural Equation |
| Jacob, Seethal / Meier, Emily | IU School of Medicine, Department of Pediatrics and Indiana Hemophilia and Thrombosis Center | Sickle Cell Trait Education for Adolescents and Young Adults |
| Kong, Nan/Moore, Sheri | Purdue University, Weldon School of Biomedical Engineering abd National Alliance on Mental Illness West Cenral, Indiana Chapter | Examining the effect of community-based programs in coping with stress during COVID-19 recovery |
| Michael, Nancy/Gaudern, Carey | University of Notre Dame, Biological Sciences and Beacon Health System – Community Impact | Building Trauma-Informed Communities through NEAR Science and Change Theory |
| Renbarger, Kalyn / Hess, Corie | Ball State University School of Nursing and Muncie Maternal Mental Health Coalition | Mitigating the Effects of COVID-19 on Maternal Mental Health Through a Community-University Partnership |
| Rodriguez, Natalia / Kajumulo, Kelly | Purdue University, Health and Human Sciences and Planned Parenthood Great Northwest, Hawaii, Alaska, Indiana, Kentucky | Examining multilevel determinants of cervical cancer and acceptability of screening innovations to address disparities among Hispanic women in Lake County,Indiana |
| Wells, Ellen / Evans, T. Eric | Purdue University, School of Health Sciences and Blackford County Concerned Citizens | Rural Environmental Health Assessment and Neighborhood-Specific Public Health Plan for Hartford City Using a Community-Engaged Approach |
2020 – Trailblazer |
||||||
|---|---|---|---|---|---|---|
|
||||||
|
||||||
| Howland, Allison / Norris, Katherine | Indiana University and Homes 4 Homeless | Hotels to Home: A study of ethical, low-barrier approaches to episodic homelessness in Monroe County, Indiana | ||||
|
||||||
|
||||||
| Spence, Lisa / Parker, Robin | Indiana University and IU Health Bloomington | Effect of Adding a Registered Dietitian in a Team Based Approach for Management of Type 2 Diabetes | ||||
|
||||||
2019 – Trailblazer |
||||||
|---|---|---|---|---|---|---|
|
||||||
|
||||||
|
||||||
|
||||||
|
||||||
|
||||||
2022 – Trailblazer Planning |
||
|---|---|---|
| Fodstad, Jill / Dwenger, Deanna | IUSM / Indiana Dept of Corrections | Improving Care for Incarcerated Hoosier Youth with Autism Spectrum Disorder through Developing an Indiana Department of Corrections Staff Training |
| Klitzman, Melissa / Davis, Tiffany | IUSM / Marion County Public Health Department | Community-University Partnership Establishing a Black Peer-Led Lactation Support Group for NICU Families |
| Kostrominova, Tatiana / Walker, Roland | IUN / Gary Health Department | Building partnership for reducing health disparities in the City of Gary through research and education |
| Miller, Michelle / Emery, Rachel | IUSM / LMPN Women’s Health Center | Building Partnerships for Trauma-Informed Care in Rural Perinatal Populations |
| Weber, Zachary / Parlett, Tyne | IUPUI / Cultivating a Belonging Culture | Development of a Student-Centric LGBTQIA+ Extension for Community Healthcare Outcomes (ECHO) Presentation Series |
2021 – Trailblazer Planning |
||
|---|---|---|
| Brandon-Friedman, Richard /Miller, Marissa | IUPUI, School of Social Work and Trans Solutions Research and Resource Center, LLC | Building Community Partnerships to Enhance the Safety and Well-being of Transgender People of Color |
| Frederickson Comer, Karen / Robertson, Richard | IU School of Informatics and Computing | Strategic Needs Assessment for Physicians’ Initiative for Demographic Analysis |
| Jones, Carmen / Cripe, Nancy Sue | Purdue University and Carroll-White Counties CASA | Child Welfare Training for Court Appointed Special Advocate (CASA) Volunteers |
| Magan, Amy/ Stinson, Kelsey | University of Indianapolis and Center for Aging & Community | UIndy-CICOA Partnership for Innovations in Healthy Aging |
| Michael, Nancy / White, Cassy | University of Notre Dame, Biological Sciences and St. Joseph County Department of Health | Developing Collaborative Public Health Approaches for Positive and Adverse Childhood Experiences |
| Trainor, Kristin / Hudson, Ken | IUPUI Department of Social Work and Whitely Community Council | Whitely Community Council and Ball State University: Partnership for Improved Health Outcomes |
| Tucker-Edmonds, Brownsyne / Maxey, Rachel / Voisard, Andrea | IU School of Medicine, Department of Obstetrics and Gynecology and MDWise and GoodwillIndy | Working Group of University and community partners to learn about Indiana maternal mortality and morbidity rates and examine the potential patient value-add of the Eskenazi Doula Pilot |
2020 – Trailblazer Planning |
||
|---|---|---|
| Enane, Leslie Anne / Koch, Sarah | IU School of Medicine Department of Pediatrics and Marion County Health Department | Building Partnerships in Tuberculosis and Refugee Health Care in Indiana |
| Renbarger, Kalyn / Hess, Cori | Ball State University and Muncie and Delaware County Maternal Mental Health Coalition | A Community-University Partnership Aimed to Improve Maternal Mental Health in Delaware County |
| Rodriquez, Natalia & Gonzalvo, Jasmine & Meredith, Ashley & Ruiz, Yumary / Hart, Margarita | Purdue University and Indiana Community Health Worker Association | Indiana Community Health Workforce Development Institute |
| Simpson, Vicki / Archibald, Lorra | Purdue University and Healthy Communities of Clinton County | Enhancing an Academic-Community Partnership to Improve Outcomes |
2019 – Trailblazer Planning |
||
|---|---|---|
| Abebe, Ephrem / Akers, Jennifer | Purdue University and Family Voices Indiana | Community-Academic Partnership for Improved Medication Use Outcomes |
| Cherian, Joseph / Shaw, Gillian | University of Notre Dame and enFocus | Building a partnership between the University of Notre Dame, the St. Joseph County Health Department, and enFocus to work towards a lead-safe county |
| Knapp, Doug / Street, Tim | Indiana University and Bradford Woods | The Development of Camp Chrysalis – A transformational program for the management of obesity and pre-diabetic conditions in adolescents. |
| Kong, Nan / Moore, Sheri | Purdue University and National Alliamnce on Mental Illness West Central Indiana | Smartphone-based Socio-behavioral Monitoring Tool Development for Early Detection and Prevention of Major Depression |
| P’Pool, April / Berman, Kathy | IUPUI and About Special Kids | Teaching Medical Students About Social Determinants of Health Through Partnership with About Special Kids and Care Conferences |
| Wadelton, Christina / Mouhiuddin, Salma / Beaty, Victoria | IUPUI, Growing Places Indy, and IU Health | Addressing Food Insecurity in Children with Special Needs through Urban Gardening |
2022 – Translational Public Health (TPH) |
||
|---|---|---|
| Jordan, Evan & Johns, Shelley | IUB/IUSM | A just in time mobile stress intervention for cancer survivors |
IP Filings Based on CTSI Projects
We would like to thank the Innovation and Commercialization Office at Indiana University, the Office of Technology Commercialization at Purdue University, and the Idea Center at the University of Notre Dame for their assistance in publishing this webpage. Each of these offices helps to identify, protect and commercialize technology that comes from discoveries and innovations made by their researchers. Examples of previously awarded projects that have resulted in IP or commercialization include:
2008 - Awards Resulting in IP Protection and Commercialization Activities |
||
|---|---|---|
| Won, You-Yeon | Purdue | Radiation-Controlled Release of Drugs for Chemo-Radiotherapy |
2010 - Awards Resulting in IP Protection and Commercialization Activities |
||
|---|---|---|
| Cooks, Robert Graham | Purdue | Morphologically Friendly Tissue Imaging |
2012 - Awards Resulting in IP Protection and Commercialization Activities |
||
|---|---|---|
| Boudouris, Bryan | Purdue | Functional Filtration Membranes |
| Rickus, Jenna | Purdue | Multianalyte Sensing |
2015 - Awards Resulting in IP Protection and Commercialization Activities |
||
|---|---|---|
| Figueiredo, Marxa L | Purdue | Anti-Angiogenesis Compound Targets Laminin Receptor in Cancer Cells |
| Thompson, David | Purdue | Method Produces Cyclodextrin with Polyrotaxane has Potential as Part of Treatment of Neimann-Pick Disease Type C |
| Won, You-Yeon | Purdue | Using Nanoparticles for Cancer Therapy |
2016 - Awards Resulting in IP Protection and Commercialization Activities |
||
|---|---|---|
| Shi, Riyi | Purdue | Portable Diagnostic Tool for Blast Injury and Other Traumatic Brain Injuries |
2017 - Awards Resulting in IP Protection and Commercialization Activities |
||
|---|---|---|
| Chen, Peng-Shen | Indiana University | Use of Subcutaneous Nerve Stimulation to Sprout Nerves |
| Corson, Timothy | Indiana University | Novel Method of Using Soluble Epoxide Hydrolase Inhibitors |
| Emir, Uzay E | Purdue | Noninvasive Ultra-short Acquisition Delay Magnetic Resonance Spectroscopy Measurement |
| Lu, Tao | Indiana University | PRMT5 Inhibitors for the Treatment of Cancer |
2018 - Awards Resulting in IP Protection and Commercialization Activities |
||
|---|---|---|
| Merrell, Jonathan | Indiana University | Revised Smart Inhaler |
| Mirmira, Raghu | Indiana University | Method for predicting susceptibility to hyperglycemia and type 1 diabetes |
2020 - Awards Resulting in IP Protection and Commercialization Activities |
||
|---|---|---|
| Ekser, Burcin | Indiana University | In Vitro Model for the Study of Liver Disease |
| Androphy, Elliot | Indiana University | Small Molecule Covalent Inhibitors of the HPV E6 Protein |
| van Kessel, Julia | Indiana University | Novel Antibiotics |
For additional, campus-specific information about project innovation and entrepreneurship please contact them using the information below.
Office of Technology Commercialization (OTC) The Convergence Center 101 Foundry Drive, Suite 2500 West Lafayette, IN 47906 Phone: 765-588-3475 Email: OTCIP@prf.org www.prf.org/innovation-and-entrepreneurship www.prf.org/otc
University of Notre Dame Licensing & Business Development The Idea Center 574-631-8825 rcox4@nd.edu https://ideacenter.nd.edu
Indiana University Innovation and Commercialization Office 518 Indiana Avenue Indianapolis, IN 46202 317-274-5905 ico@iu.edu https://research.iu.edu/innovation-commercialization
