This retrospective chart review found that 1) acute/pre-existing renal disease; 2) oxygen requirement at the time of hospitalization; and 3) initial C-reactive protein were independent predictors for the development of severe COVID19 infections.
- A single-center, retrospective observational study, which included patients with confirmed RT-PCR assay of a nasopharyngeal swab from March 8th to April 8th, 2020 were included
- Severe COVID-19 infection was defined as a patient requiring mechanical ventilation
- A total of 197 hospitalized patients, with mean (SD) age of the cohort was 60.6 (16.2) years. 103 (52.3%) were male and 156 (82.1%) were black
- Most common underlying conditions: Hypertension, 138 (70.1%) patients; diabetes, 73 (37.1%); and chronic pulmonary diseases in 38 (19.3%) patients.
- 60 (31.6%) had a sick contact
- Predictors for severe COVID-19
- Pre-existing renal disease: OR 7.4 (95%CI: 2.5, 22.0)
- Elevated creatinine from baseline: OR 2.7 (95%CI: 1.3, 5.6)
- Oxygen requirement: OR 2.9 (95%CI: 1.3, 6.7)
- Initial CRP value: OR 1.006 (95%CI: 1.001, 1.01)
- Limitations: Some ambiguity on defining certain variables within multivariate model.
