Using an accelerated failure time-based modeling study, estimated median time virus RNA detection ranged from 15.6-24.5 days in mild COVID-19 cases to 30.9-33.9 days in severe cases.
- This was a prospective analysis of 49 coronavirus disease cases in Guangdong, China (mild cases, n=43; severe cases, n=6)
- 480 specimens were included (nasopharyngeal, fecal, sputum, and throat), tested using rRT-PCR
- The estimated time until complete loss of virus RNA detection ranged from 45.6 – 46.3 days in mild cases and from 48.9 – 49.4 days in severe cases
- Limitations: Detection of RNA particles does not imply existence of infectious virus. A number of missing specimens was noted. May not be generalization to all infections with SARS-CoV-2, such as asymptomatic cases.