Laboratory study

This observational study found that half of the patient with negative IgM and RT-qPCR-positive SARS-CoV-2 had severe COVID-19 disease.  IgM-based gold immunochromatographic assay (GICA) is the test used within this study, to investigate its utility Severe cases were defined as Read More
This study found that admission C-reactive protein (CRP) correlated with disease severity and tended to be a good predictor of adverse outcome. Data of COVID-19 patients with clinical outcome in a designated hospital in Wuhan, China, were retrospectively collected and Read More
Findings from this small study suggested that a qualitative fit test alone is unable to fully assess mask integrity and that at the doses required for sterilization, gamma radiation degrades the filtration efficiency of N95 masks. A set of 3M 8210, Read More
This retrospective study show age-dependent expression of ACE2 in nasal epithelium, the first point of contact for SARS-CoV-2 and the human body. This may shed light on why children only appear to account for a small proportion of COVID-19 cases.  Angiotensin-converting Read More
This study systematically analyzed key immunological parameters spanning the course of infection, obtained viral genomes directly from clinical samples, and delineated factors associated with prognosis and epidemiological features. Authors analyzed the clinical, molecular and immunological data from 326 confirmed cases Read More
This meta-analysis found that individuals with either severe cases or non-surviving cases of COVID-19 had lower platelet counts compared to individuals with non-severe and surviving cases, suggesting that thrombocytopenia may be a risk factor for COVID-19 progressing into a more Read More
This retrospective study found inconsistent results of RT-PCR-testing using throat and anal swabs for monitoring SARS-CoV-2 infection. RT-PCR assay on throat and anal swabs were simultaneously tested in 212 of 2138 pediatric patients with suspected SARS-CoV-2 infection in Wuhan Children’s Read More
This study found that SARS-CoV-2 testing results via nasopharyngeal swab and saliva sample were comparable, and that saliva is an acceptable alternative source for detecting SARS-CoV-2 nucleic acid. Study used Cepheid Xpert Xpress SARS-CoV-2 (Sunnyvale, CA) PCR test for both Read More
Using an accelerated failure time-based modeling study, estimated median time virus RNA detection ranged from 15.6-24.5 days in mild COVID-19 cases to 30.9-33.9 days in severe cases.  This was a prospective analysis of 49 coronavirus disease cases in Guangdong, China Read More
This study confirms that WHO-recommended hand sanitizer formulations are effective at killing the coronavirus. Researchers looked at how well World Health Organization–recommended hand rub formulations killed the virus, at full strength and multiple dilutions, and of the active ingredients. All Read More

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