Review: Saliva as an alternate specimen source for detection of SARS-CoV-2 in symptomatic patients using Cepheid Xpert Xpress SARS-CoV-2

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Review: Saliva as an alternate specimen source for detection of SARS-CoV-2 in symptomatic patients using Cepheid Xpert Xpress SARS-CoV-2

Review: Saliva as an alternate specimen source for detection of SARS-CoV-2 in symptomatic patients using Cepheid Xpert Xpress SARS-CoV-2

This study found that SARS-CoV-2 testing results via nasopharyngeal swab and saliva sample were comparable, and that saliva is an acceptable alternative source for detecting SARS-CoV-2 nucleic acid.

  • Study used Cepheid Xpert Xpress SARS-CoV-2 (Sunnyvale, CA) PCR test for both samples
  • A total of 156 paired NPS and saliva specimens were tested, all symptomatic patients from hospital ED or inpatient service
  • The overall SAR-CoV-2 positivity was 50/156 (32.1%), while the community rate of positivity during the week of collection was 11.1%
  • 153/156 (98% [94.48 -99.60%, 95% Confidence Interval (CI)]) samples were in overall agreement.
  • 47/49 samples were positive in saliva when compared to the NPS resulting in a positive percent agreement of 96% (86.02 -99.5%, 95% CI).
  • A single sample demonstrated detectable levels of SARS-CoV-2 nucleic acid in the saliva, but the NPS was negative (1/106) resulting in a negative percent agreement of 99% (94.86-99.98%, 95% CI)

 

|2020-05-19T11:54:38-04:00May 19th, 2020|COVID-19 Literature|0 Comments

About the Author: Megan McHenry

Megan McHenry

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