Servicecore – Do not remove
Service Cores
Indiana CTSI Research Service Cores and Resources
IU Indianapolis
Behavioral Phenotyping Core (BPC)
The BPC advises upon and/or conducts behavioral experiments in rats or mice. Assays include assessments of general sensory and motor function, cognitive processing, affective reactivity, and PK/PD relationships in drug evaluations.
Purdue University
Bindley Bioscience Center
Biomolecular technologies, imaging and cytomics, bioinformatics support, and bionanotechnology with an emphasis on nanochemistry and functionalization of nanomaterials.
IU Indianapolis
Biochemical Genetics Laboratory
Our laboratory provides clinically validated liquid chromatography tandem mass spectrometry testing for researchers interested in quantifying metabolites in a wide range of biospecimens with a particular focus on amino acid, organic acid, and acylcarnitine analyses.
Purdue University
Biological Evaluation (BE-SR)
The Biological Evaluation Shared Resource performs highly customizable efficacy testing of novel drug or therapies for antitumor activity. We also acquire blood or tissues for pharmacokinetic or pharmacodynamic analyses.
IU Bloomington
Biostatistics Consulting Center
The Biostatistics Consulting Center provides study design and data analysis for health-related research, including study design, grant or protocol development, sample size and power calculations, data management, data analysis, and scientific writing. Support can range from hourly support on a short-term project to including a biostatistician on a long-term grant collaboration.
Purdue University
Birck Nanotechnology Center
Nanofabrication cleanroom, bio-pharma clean room, nanometrology laboratories, nanomanufacturing laboratories, microelectronics and microfuidics fabrication and testing laboratories, 3D cell culture and tissue chip laboratories
IU Indianapolis
Cellular Response Technologies Core
Conduct validated and highly reproducible in vitro and in vivo angiogenesis, endothelial, hematopoietic and multi-parametric flow cytometry assays and their role in normal and patient-related hematologic and cardiovascular disorders. The ABC also manages an IncuCyte Zoom and Seahorse XFp.
Purdue University
Center for Comparative Translational Research
Translational research spans the continuum in which research findings from the researcher’s lab are moved to the patients ‘bedside’ (human) or ‘barn’ (animal). The Center for Comparative Translational Research (CTR) wants to make bridging the gap between benchtop and bedside/barn easier by helping researchers conduct comparative animal studies using induced and spontaneous disease models. It does so by facilitating, coordinating, integrating …
IU Bloomington
Center for Evaluation, Policy, and Research (CEPR)
CEPR provides rigorous, high-quality, non-partisan evaluation, policy analyses, and research for meaningful, useful, and actionable data for clients and project stakeholders. Clients include international, federal and state agencies, public and private organizations, and foundations and endowments working across a range of fields and disciplines.
IU Bloomington
CISAB Mechanisms of Behavior Laboratory
The Mechanisms of Behavior Core offers the equipment, reagents, bench space, and expertise to answer questions related to the roles of genetics and hormones in relation to animal behavior.
IU Indianapolis
Electrophysiology Core
The Electrophysiology Core performs rodent brain slice electrophysiological recordings to measure brain cell function.
Purdue University
Flow Cytometry and Cell Sorting Facility
The Purdue Flow Cytometry Core Facility provides instrumentation, data analysis software, training and technical expertise for flow cytometry analysis and cell sorting. Our capabilities also include the characterization of genome and transcriptomes using the Fluidigm C1 and 10X Genomics systems, in partnership with the Purdue Genomics Core Facility.
Notre Dame
Freimann Life Sciences Center (FLSC)
The Freimann Life Sciences Center is comprised of 2 state-of-the-art animal facilities equipped to house a wide variety of vertebrates. FLSC’s key goals are to support the University of Notre Dame’s teaching and research. The Center is fully accredited by the Association for Assessment and Accreditation of Laboratory Animal Care International.
IU Indianapolis
Genome Editing Center
The Indiana University Genome Editing Center (IUGEC) is a shared resource whose mission is to provide Indiana University and external investigators access to state-of-the-art genome editing technologies by assisting with the generation of genetically modified mouse models and cell lines in a time- and cost-effective manner.
Purdue University
Histology Research Laboratory (HRL)
The Histology Research Laboratory is a full service histology laboratory that provides general histology, immunohistochemistry, frozen sectioning, decalcified and undecalcified bone histology, and slide digitization services. Board certified veterinary pathologists are also available for consultation.
Purdue University
Imaging Facility
The Bioscience Imaging Facility, Purdue University, is a 24hr/7day access core facility specializing in confocal microscopy, multi-photon and light sheet microscopy, pre-clinical molecular and nuclear imaging and computed tomography (mCT) with offline analysis workstations.
IU Indianapolis
Immunohistochemistry Research Lab (IHC Research Lab)
The Immunohistochemistry Research Lab specializes in assisting researchers with histologic and immunohistochemical labeling of cells or tissue sections as well as collaborations with surgical pathologists.
IU Indianapolis
In Vivo Therapeutics Core (IVT)
The In Vivo Therapeutics Core (IVTC) supports the research and development of safe and more efficacious drug treatment. The IVTC provides cost-effective and comprehensive services including, but not limited to, on-site breeding facilities as well as a numerous in vivo pharmacology models to facilitate the development and testing of novel pharmacological & cellular therapies.
IU Indianapolis
In-Vivo Imaging Core
The In-Vivo Imaging Core provides imaging services for clinical trials, observational, and preclinical studies. We also provide radiochemistry support for molecular imaging. Currently, the Imaging Core is equipped with state-of-the-art imaging systems, including 3T MRI scanners, PET-CT scanners, Bruker 9.4 T preclinical PET-MRI scanner, a Siemens Eclipse Medical Cyclotron, and Radiochemistry Facilities. Highly skilled faculty and staff are available to assist with research …
IU Indianapolis
Indiana Center for Biological Microscopy (ICBM)
The ICBM provides researchers with access to laser-scanning confocal, 2-photon and epi-fluorescence microscopes (http://www.medicine.iupui.edu/ICBM/USING-THE-FACILITY). Center personnel train individual researchers to use all imaging systems and provide expert help in the design, conduct and analysis of imaging studies. As necessary, center personnel can also be hired to conduct microscopy studies for laboratories lacking the necessary expertise.
Notre Dame
Integrated Imaging Facility (NDIIF)
The Notre Dame Integrated Imaging Facility (NDIIF) is a state-of-the-art research core that makes available to the Notre Dame science and engineering community, as well as external customers, an integrated suite of sophisticated microscopes and imaging stations. The NDIIF also provides resident professional staff (three Ph.D.-level imaging specialists and two technicians) to guide the non-expert users.
IU Indianapolis
Investigational Agent Acquisition Program
Goal: The goal of the CTSI Investigational Agent Acquisition Program (IAAP) is to assist CTSI investigators seeking investigational agents for use in clinical trials.
Scope: The IAAP program will assist in acquiring drugs, neutraceuticals, biologics or other materials to be used in a Investigational New Drug Application or IND-exempt clinical trial.
Eligibility: Any faculty within the CTSI member institutions.
Overview: Moving bench research into …
IU Indianapolis
Islet and Physiology Core
The Islet and Physiology Core of the Center for Diabetes and Metabolic Diseases provides investigators with the capability to obtain high quality rodent pancreatic islets for study. The Core also provides services for islet transplantation and will assist investigators who wish to perform immunohistochemistry, immunofluorescence, and/or analysis of beta cell mass on whole pancreata from mouse and rat models.
Notre Dame
Keck Center for Transgene Research (resources)
Unique research resources available for collaboration
IU Indianapolis
Laboratory Animal Resource Center (LARC)
The Laboratory Animal Resource Center (LARC) provides basic husbandry, training, supplies, and specialized service support for medical research at IU School of Medicine.
IU Bloomington
Laboratory Animal Resources (LAR)
LAR provides housing, food, water, bedding, enrichment and medical care for animals housed in LAR animal facilities to be used for research. Research is overseen by an Institutional Animal Care and Use Committee (IACUC) and the Institutional Official and is accredited by AAALAC International and their three primary standards (The Guide for the Care and Use of Laboratory Animals, Guide for the Care and Use of Agricultural Animals in Research and Teaching, and the European …
IU Bloomington
Laboratory for Biological Mass Spectrometry (LBMS)
The LBMS uses mass spectrometry to characterize proteins as well as other biologically-derived molecules. It specializes in the characterization of protein post-translational modifications, including glycosylation, phosphorylation, acetylation and persulfidation (S-sulfhydration). We also have an emphasis on identification of protein-interactions (including determination of protein-protein crosslinks) and quantitative comparisons of complex samples.
IU Bloomington
Macromolecular Crystallography Facility Integrated with the Crystallization Automation Facility (MCF/CAF)
The Macromolecular X-ray Crystallography Facility provides all resources for Crystal Screening and Optimization, Data Collection and Structure Determination of macromolecules.
Notre Dame
Molecular Structure Facility
The Molecular Structure Facility at the University of Notre Dame provides for X-Ray structural studies of small (ca. 2kDa) molecules. The Facility has the capability to examine a wide range of molecules from “light atom” biologically relevant to metal-complexed compounds which can be readily analyzed using non-destructive techniques.
IU Indianapolis
Multiplex Analysis Core (MAC)
The Multiplex Analysis Core (MAC) offers microplate-based immunoassay systems that can perform multiplex analysis of multiple different analytes in a single sample. The MAC uses a Bio-Plex 200 Multiplex System with High Throughput Fluidics based on Luminex technology.
IU Bloomington
Oxidative Stress and Environmental Analysis Core
The Oxidative Stress Environmental Analysis Core laboratory has established a number of measurements for assessing oxidative stress and damage in a variety of biological samples with excellent accuracy and reproducibly using state of the art LC-MSMS, GC, and PCR equipment.
IU Bloomington
Physical and Biochemistry Instrumentation Facility (PBIF)
The PBIF provides resources to characterize particle properties as well as macromolecular interactions.
Purdue University
Pre-Clinical Research Laboratory (PCL)
The Pre-Clinical Research Laboratory (PCL) helps researchers conduct pre-clinical animal research by providing research expertise, technical support, surgical experience, and surgical facilities and equipment. The PCL is a multidisciplinary laboratory where researchers conduct advanced clinical and applied research using induced animal models ranging from rodents to pigs and sheep
IU Indianapolis
Preclinical Modeling and Therapeutics Core (PMTC)
The Preclinical Modeling and Therapeutics Core (PMTC) facilitates the development of pharmacological and cellular therapies for cancer. It provides advanced resources essential for the preclinical validation of novel drug targets and biomarkers of cancer. The PMTC provides expertise in:
• Cellular response technologies
• Breeding of specialized mouse strains
• Tumor modeling
• In vivo therapeutics efficacy & safety testing
• …
Purdue University
Proteomics Facility
The Purdue Proteomics Facility provides chromatography, mass spectrometry and bioinformatic resources for the research communities on campus and beyond for protein characterization. These services include protein identification, relative and absolute quantitation, mapping post-translational modifications, and discovering new protein complexes and protein-protein interactions from a wide variety of sample types such as gel bands, cell or tissue lysates, and plasma or …
Purdue University
Purdue MRI Facility
The Purdue MRI Facility houses two 3T full body MRI systems and one 7T small bore (animal) MRI system that are available for research involving MRI, MR spectroscopy, and other MR applications.
IU Indianapolis
Regenstrief Data Services
Services RDS offerings include, but are not limited to:
• Feasibility
• DIY: i2b2
• Cohorts
• Recruitment Lists
• Registries
• Patient Lists
• Geocoding
• Phenotyping
• Deidentification
• EHR Integration/Innovation
• Application Development
• Application Prototypes
• Natural Language Processing (NLP)
• Data Linkage
• Machine Learning Models …
IU Indianapolis
3D Bioprinting Core (3DBPC)
We provide 3D bioprinting services with the Regenova Bio 3D Printer to generate tissue models (e.g., bone and liver) and we provide FABRICA bioreactor platforms to properly perfuse bioprinted tissue models with blood or cell culture media.
Purdue University
Transgenic and Genome Editing Facility (TGEF)
Offering transgenic and CRISPR-mediated targeted gene editing in mice and rats; gene-targeting in mouse embryonic stem cells (ES) cells; embryo and sperm cryopreservation; in vitro fertilization; rederivation for importation or clean-up of infected lines. Also offering assistance with project design and mouse/rat breeding colony maintenance.
Purdue University
Translational Pharmacology Facility
The PTP Core offers automated blood monitoring in rodents and large animals utilizing stress free sampling through CulexTM technology. We perform a host of services from early lead identification PK and PD assessment through product testing of human formulations in pigs and minipigs, including preclinical formulation development, biodistribution studies, metabolomics analysis, and in vivo toxicological evaluation.
Purdue University
Veterinary Clinical Trials (VCT)
The Veterinary Clinical Trials Support Service (VCT) facilitates veterinary clinical trials and provides expertise and technical support for translational clinical investigations using animal models of spontaneous, naturally-occurring diseases in client-owned animals and for trials leading to novel drugs or devices.