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Service Cores
Indiana CTSI Research Service Cores and Resources
IU Indianapolis
Biochemical Genetics Laboratory
Our laboratory provides clinically validated liquid chromatography tandem mass spectrometry testing for researchers interested in quantifying metabolites in a wide range of biospecimens with a particular focus on amino acid, organic acid, and acylcarnitine analyses.
Purdue University
Biological Evaluation (BE-SR)
The Biological Evaluation Shared Resource performs highly customizable efficacy testing of novel drug or therapies for antitumor activity. We also acquire blood or tissues for pharmacokinetic or pharmacodynamic analyses.
IU Indianapolis
Biospecimen Collection and Banking Core
The IUSCCC Biospecimen Collection and Banking Core (BC2) provides an extensive collection of well-annotated samples from patients with malignancy and normal controls to support studies exploring the biologic basis of cancer, move basic findings to the clinic, and probe the biology underlying clinical and population phenomena.
IU Indianapolis
Biospecimen Management Core (CTSL/SSF)
The CTSI Biospecimen Management Core consists of the Specimen Storage Facility (SSF) and the Clinical and Translational Support Laboratory (CTSL), which together offer cost efficient sample processing & storage services with a focus on consistent quality and sample integrity.
Purdue University
Birck Nanotechnology Center
Nanofabrication cleanroom, bio-pharma clean room, nanometrology laboratories, nanomanufacturing laboratories, microelectronics and microfuidics fabrication and testing laboratories, 3D cell culture and tissue chip laboratories
IU Indianapolis
Cellular Response Technologies Core
Conduct validated and highly reproducible in vitro and in vivo angiogenesis, endothelial, hematopoietic and multi-parametric flow cytometry assays and their role in normal and patient-related hematologic and cardiovascular disorders. The ABC also manages an IncuCyte Zoom and Seahorse XFp.
Notre Dame
Center for Zebrafish Research
3,000 sq. ft. facility consisting of 8 double-sided racks and 38 single-sided racks, maintained independently. Separate room houses the nursery.
IU Indianapolis
Clinical Pharmacology Analytical Core (CPAC)
The Clinical Pharmacology Analytical core provides drug and metabolite concentrations from a variety of biological matrices such as (but not limited to): plasma, urine, CSF, and tissue using HPLC-MS/MS. Additional services include protein binding of drugs, formulation studies, drug stability, drug metabolism, and metabolite screening.
IU Indianapolis
Electrophysiology Core
The Electrophysiology Core performs rodent brain slice electrophysiological recordings to measure brain cell function.
IU Indianapolis
Histology and Histomorphometry Core (HHC)
Histology and Histomorphetry Core (HHC) provides histological and histomorphometric services for basic science (non-clinical) research. Mineralized (plastic embedded), soft tissue (paraffin embedded), and cryopreserved specimens can be processed by the facility.
Purdue University
Histology Research Laboratory (HRL)
The Histology Research Laboratory is a full service histology laboratory that provides general histology, immunohistochemistry, frozen sectioning, decalcified and undecalcified bone histology, and slide digitization services. Board certified veterinary pathologists are also available for consultation.
Purdue University
Imaging Facility
The Bioscience Imaging Facility, Purdue University, is a 24hr/7day access core facility specializing in confocal microscopy, multi-photon and light sheet microscopy, pre-clinical molecular and nuclear imaging and computed tomography (mCT) with offline analysis workstations.
IU Indianapolis
Immunohistochemistry Research Lab (IHC Research Lab)
The Immunohistochemistry Research Lab specializes in assisting researchers with histologic and immunohistochemical labeling of cells or tissue sections as well as collaborations with surgical pathologists.
IU Indianapolis
In Vivo Therapeutics Core (IVT)
The In Vivo Therapeutics Core (IVTC) supports the research and development of safe and more efficacious drug treatment. The IVTC provides cost-effective and comprehensive services including, but not limited to, on-site breeding facilities as well as a numerous in vivo pharmacology models to facilitate the development and testing of novel pharmacological & cellular therapies.
IU Indianapolis
In-Vivo Imaging Core
The In-Vivo Imaging Core provides imaging services for clinical trials, observational, and preclinical studies. We also provide radiochemistry support for molecular imaging. Currently, the Imaging Core is equipped with state-of-the-art imaging systems, including 3T MRI scanners, PET-CT scanners, Bruker 9.4 T preclinical PET-MRI scanner, a Siemens Eclipse Medical Cyclotron, and Radiochemistry Facilities. Highly skilled faculty and staff are available to assist with research …
IU Indianapolis
Indiana Center for Biological Microscopy (ICBM)
The ICBM provides researchers with access to laser-scanning confocal, 2-photon and epi-fluorescence microscopes (http://www.medicine.iupui.edu/ICBM/USING-THE-FACILITY). Center personnel train individual researchers to use all imaging systems and provide expert help in the design, conduct and analysis of imaging studies. As necessary, center personnel can also be hired to conduct microscopy studies for laboratories lacking the necessary expertise.
Notre Dame
Integrated Imaging Facility (NDIIF)
The Notre Dame Integrated Imaging Facility (NDIIF) is a state-of-the-art research core that makes available to the Notre Dame science and engineering community, as well as external customers, an integrated suite of sophisticated microscopes and imaging stations. The NDIIF also provides resident professional staff (three Ph.D.-level imaging specialists and two technicians) to guide the non-expert users.
Notre Dame
Integrated Imaging Facility – Histology Core (NDHC)
The Notre Dame Histology Core (NDHC) provides a means to examine biological processes in mice, rats, frogs, zebra fish, fruit flies, sheep bone, and even human tissue by use of immunohistochemical techniques and pathology.
IU Indianapolis
Islet and Physiology Core
The Islet and Physiology Core of the Center for Diabetes and Metabolic Diseases provides investigators with the capability to obtain high quality rodent pancreatic islets for study. The Core also provides services for islet transplantation and will assist investigators who wish to perform immunohistochemistry, immunofluorescence, and/or analysis of beta cell mass on whole pancreata from mouse and rat models.
IU Indianapolis
IU School of Medicine Center for Electron Microscopy (iCEM)
The Indiana University School of Medicine Electron Microscopy Center is a full service research laboratory providing both Transmission and Scanning Electron Microscopy. The service provided can apply both traditional methods and recent technical developments to suit the investigator’s needs.
IU Bloomington
Laboratory for Biological Mass Spectrometry (LBMS)
The LBMS uses mass spectrometry to characterize proteins as well as other biologically-derived molecules. It specializes in the characterization of protein post-translational modifications, including glycosylation, phosphorylation, acetylation and persulfidation (S-sulfhydration). We also have an emphasis on identification of protein-interactions (including determination of protein-protein crosslinks) and quantitative comparisons of complex samples.
Notre Dame
Mass Spectrometry and Proteomics Facility
Analysis of large and small molecules using several ionization methods, low or high resolution, hyphenated techniques, proteomics, and metabolomics.
Purdue University
Metabolite Profiling Facility (MPF)
The Metabolite Profiling Facility (MPF) provides both qualitative (comparative analysis) and quantitative (absolute concentrations) metabolite chemical analysis in complex biological systems.
IU Indianapolis
Multiplex Analysis Core (MAC)
The Multiplex Analysis Core (MAC) offers microplate-based immunoassay systems that can perform multiplex analysis of multiple different analytes in a single sample. The MAC uses a Bio-Plex 200 Multiplex System with High Throughput Fluidics based on Luminex technology.
IU Bloomington
Oxidative Stress and Environmental Analysis Core
The Oxidative Stress Environmental Analysis Core laboratory has established a number of measurements for assessing oxidative stress and damage in a variety of biological samples with excellent accuracy and reproducibly using state of the art LC-MSMS, GC, and PCR equipment.
Purdue University
Pre-Clinical Research Laboratory (PCL)
The Pre-Clinical Research Laboratory (PCL) helps researchers conduct pre-clinical animal research by providing research expertise, technical support, surgical experience, and surgical facilities and equipment. The PCL is a multidisciplinary laboratory where researchers conduct advanced clinical and applied research using induced animal models ranging from rodents to pigs and sheep
IU Indianapolis
Preclinical Modeling and Therapeutics Core (PMTC)
The Preclinical Modeling and Therapeutics Core (PMTC) facilitates the development of pharmacological and cellular therapies for cancer. It provides advanced resources essential for the preclinical validation of novel drug targets and biomarkers of cancer. The PMTC provides expertise in:
• Cellular response technologies
• Breeding of specialized mouse strains
• Tumor modeling
• In vivo therapeutics efficacy & safety testing
• …
Purdue University
Proteomics Facility
The Purdue Proteomics Facility provides chromatography, mass spectrometry and bioinformatic resources for the research communities on campus and beyond for protein characterization. These services include protein identification, relative and absolute quantitation, mapping post-translational modifications, and discovering new protein complexes and protein-protein interactions from a wide variety of sample types such as gel bands, cell or tissue lysates, and plasma or …
IU Indianapolis
SNRI Biomarker Core
The Stark Neurosciences Research Institute Biomarker Core provides biomarker services to investigators. Multiplexing of targets in tissues or on a slide, investigators can detect changes in their samples and target specific pathways of interest in disease.
IU Indianapolis
3D Bioprinting Core (3DBPC)
We provide 3D bioprinting services with the Regenova Bio 3D Printer to generate tissue models (e.g., bone and liver) and we provide FABRICA bioreactor platforms to properly perfuse bioprinted tissue models with blood or cell culture media.
IU Indianapolis
Translation Core
The Translation Core provides services that facilitate the conduct of research involving human subjects, including supplying low-cost, high-quality analyte measurements for a variety of hormones, cytokines, lipids and other analytes. Translation Core human studies services include phenotyping (i.e. GTT, clamp studies, tracer studies), and access to a biobank of human tissues and serum.
Purdue University
Translational Pharmacology Facility
The PTP Core offers automated blood monitoring in rodents and large animals utilizing stress free sampling through CulexTM technology. We perform a host of services from early lead identification PK and PD assessment through product testing of human formulations in pigs and minipigs, including preclinical formulation development, biodistribution studies, metabolomics analysis, and in vivo toxicological evaluation.
IU Indianapolis
Translational Research Core (TRC)
The Translational Research Core specializes in assisting researchers with the identification/development and analysis of laboratory correlates in translational research.
Purdue University
Veterinary Clinical Trials (VCT)
The Veterinary Clinical Trials Support Service (VCT) facilitates veterinary clinical trials and provides expertise and technical support for translational clinical investigations using animal models of spontaneous, naturally-occurring diseases in client-owned animals and for trials leading to novel drugs or devices.